* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, May 10, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Flutter Entertainment eyes U.S. prediction markets amid growing interest – Sports Business Journal

    Flutter Entertainment Sets Its Sights on U.S. Prediction Markets as Interest Soars

    SXSW Rom-Com ‘I Really Love My Husband’ Acquired for U.S. Release – Variety

    Heartfelt Romance: ‘I Really Love My Husband’ Set to Captivate U.S. Audiences!

    Georgia Entertainment CEO says large-scale production is slowing down – Decaturish

    Georgia Entertainment CEO Warns of Slowdown in Large-Scale Productions

    Zugalu Entertainment Welcomes Crimson Herring Studios to Its Family!

    Fall 2025 TV Schedule: Your Guide to the Complete Lineup – Wyoming News Now

    Get Ready for Fall 2025: Your Ultimate Guide to the Exciting TV Lineup!

    Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

    Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Harnessing emerging technologies to power a small business – The Oaklandside

    Unlocking Success: How Emerging Technologies Can Transform Your Small Business

    Artificial intelligence (AI) – The Guardian

    Unlocking the Future: How Artificial Intelligence is Transforming Our World

    Technology Innovation to Take Center Stage at The 2025 National Restaurant Association Show – Restaurant Technology News

    Get Ready for a Tech Revolution: The 2025 National Restaurant Association Show Unveils Cutting-Edge Innovations!

    Newmont signs deal to use Chrysos Corporation technology – Capital Brief

    Newmont Partners with Chrysos Corporation to Revolutionize Mining Technology

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Flutter Entertainment eyes U.S. prediction markets amid growing interest – Sports Business Journal

    Flutter Entertainment Sets Its Sights on U.S. Prediction Markets as Interest Soars

    SXSW Rom-Com ‘I Really Love My Husband’ Acquired for U.S. Release – Variety

    Heartfelt Romance: ‘I Really Love My Husband’ Set to Captivate U.S. Audiences!

    Georgia Entertainment CEO says large-scale production is slowing down – Decaturish

    Georgia Entertainment CEO Warns of Slowdown in Large-Scale Productions

    Zugalu Entertainment Welcomes Crimson Herring Studios to Its Family!

    Fall 2025 TV Schedule: Your Guide to the Complete Lineup – Wyoming News Now

    Get Ready for Fall 2025: Your Ultimate Guide to the Exciting TV Lineup!

    Blackstone River Theatre presents music from Scotland with Cantrip – The Valley Breeze

    Experience the Enchanting Sounds of Scotland: Cantrip Takes the Stage at Blackstone River Theatre!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Harnessing emerging technologies to power a small business – The Oaklandside

    Unlocking Success: How Emerging Technologies Can Transform Your Small Business

    Artificial intelligence (AI) – The Guardian

    Unlocking the Future: How Artificial Intelligence is Transforming Our World

    Technology Innovation to Take Center Stage at The 2025 National Restaurant Association Show – Restaurant Technology News

    Get Ready for a Tech Revolution: The 2025 National Restaurant Association Show Unveils Cutting-Edge Innovations!

    Newmont signs deal to use Chrysos Corporation technology – Capital Brief

    Newmont Partners with Chrysos Corporation to Revolutionize Mining Technology

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Air Force Invests in Whisper’s Ultraquiet Propulsion Technology – FLYING Magazine

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trump administration set to overhaul Biden’s AI chip export regulations – TechHQ

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Hypoimmune cells resist rejection in monkeys

October 24, 2023
in Science
Hypoimmune cells resist rejection in monkeys
Share on FacebookShare on Twitter

Genetic engineering to block immune destruction of transplanted cells succeeds in macaques.

A major challenge in the development of cell therapies is how to stop a patient’s immune response from killing transplanted cells derived from an unmatched donor. Various approaches to address this problem are under investigation, but a particularly elegant solution would be to create ‘universal’ donor cells that could be transplanted into any recipient without being rejected. In a study in Nature Biotechnology, Schrepfer and colleagues1 describe an exciting step toward this goal in a non-human primate model. Using donor cells with three genetic modifications — deletion of human leukocyte antigen (HLA) class I and II molecules and overexpression of CD47 — the authors demonstrate sustained immune evasion by human and macaque induced pluripotent stem cells (iPSCs) in immunocompetent rhesus macaques. This work is important because it is likely to pave the way to cell therapies that avoid immune rejection without the need for immunosuppression.

This is a preview of subscription content, access via your institution

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

209,00 € per year

only 17,42 € per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Log in

Learn about institutional subscriptions

Read our FAQs

Contact customer support

Fig. 1: Cellular engineering to generate hypoimmune cells.

References

Hu, X. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01784-x (2023).

Article 
PubMed 

Google Scholar 

Chen, H. et al. Biol. Res. 48, 59 (2015).

Article 
PubMed 
PubMed Central 

Google Scholar 

Riolobos, L. et al. Mol. Ther. 21, 1232–1241 (2013).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Mattapally, S. et al. J. Am. Heart Assoc. 7, e010239 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kadri, N. et al. Curr. Top. Microbiol. Immunol. 395, 95–114 (2016).

CAS 
PubMed 

Google Scholar 

Gornalusse, G. G. et al. Nat. Biotechnol. 35, 765–772 (2017).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Quatrini, L. et al. Nat. Immunol. 19, 954–962 (2018).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Deuse, T. et al. J. Exp. Med. 218, e20200839 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Deuse, T. et al. Nat. Biotechnol. 37, 252–258 (2019).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Gravina, A. et al. Nat. Biotechnol. 41, 717–727 (2023).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Zhao, L., Teklemariam, T. & Hantash, B. M. Stem Cell Res. 13, 342–354 (2014).

Article 
CAS 
PubMed 

Google Scholar 

Download references

Author information

Authors and Affiliations

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Asuncion Borrero Borrego & Saar Gill

Salamanca Biomedical Institute (IBSAL), University of Salamanca, Salamanca, Spain

Asuncion Borrero Borrego

Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA

Saar Gill

Cellular Therapy and Transplantation, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA

Saar Gill

Corresponding author

Correspondence to
Saar Gill.

Ethics declarations

Competing interests

The authors declare no competing interests.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Borrero Borrego, A., Gill, S. Hypoimmune cells resist rejection in monkeys.
Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02013-1

Download citation

Published: 23 October 2023

DOI: https://doi.org/10.1038/s41587-023-02013-1

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Nature.com – https://www.nature.com/articles/s41587-023-02013-1

Tags: CellsHypoimmunescience
Previous Post

Compressed Perturb-seq enables highly efficient genetic screens

Next Post

Scalable genetic screening for regulatory circuits using compressed Perturb-seq

‘Active Management’ Harms Forests — And It’s About to Get a Whole Lot Worse – The Revelator

‘Active Management’ Harms Forests — And It’s About to Get a Whole Lot Worse – The Revelator

May 10, 2025

Unlocking the Future: How Innovation Funds Propel Breakthroughs in AI, Bioengineering, and Materials Science

May 10, 2025
Talking Animals: Veteran science journalist Stephen S. Hall recounts reporting and research that yielded Slither, singular book on snakes – WMNF 88.5 FM

Unraveling the Secrets of Snakes: A Journey with Veteran Science Journalist Stephen S. Hall

May 10, 2025
Lifestyle Lookout: Mother’s Day brunch in Bellingham, Big Jam Stories in Ferndale and The Spring Wine Walk – My Bellingham Now

Unforgettable Mother’s Day Brunch, Big Jam Stories, and the Spring Wine Walk: Exciting Events in Bellingham and Ferndale!

May 10, 2025
WCK Forced to Halt Cooking in Gaza as Supplies Run Out – World Central Kitchen

World Central Kitchen Suspends Operations in Gaza Amid Supply Crisis

May 10, 2025
China Reacts to Trump Claims About ‘Suffering’ Chinese Economy – Newsweek

China Responds to Trump’s Claims of Economic Struggles: What You Need to Know

May 10, 2025
Flutter Entertainment eyes U.S. prediction markets amid growing interest – Sports Business Journal

Flutter Entertainment Sets Its Sights on U.S. Prediction Markets as Interest Soars

May 10, 2025
Optimizing Human Health On Earth And In Space – Texas A&M Today

Optimizing Human Health On Earth And In Space – Texas A&M Today

May 10, 2025
Rep. Marjorie Taylor Greene says she won’t run for U.S. Senate – NBC News

Marjorie Taylor Greene Declares She’s Not Entering the Senate Race!

May 10, 2025
Harnessing emerging technologies to power a small business – The Oaklandside

Unlocking Success: How Emerging Technologies Can Transform Your Small Business

May 10, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (597)
  • Economy (608)
  • Entertainment (21,521)
  • General (15,210)
  • Health (9,650)
  • Lifestyle (613)
  • News (22,149)
  • People (611)
  • Politics (615)
  • Science (15,830)
  • Sports (21,118)
  • Technology (15,598)
  • World (598)

Recent News

‘Active Management’ Harms Forests — And It’s About to Get a Whole Lot Worse – The Revelator

‘Active Management’ Harms Forests — And It’s About to Get a Whole Lot Worse – The Revelator

May 10, 2025

Unlocking the Future: How Innovation Funds Propel Breakthroughs in AI, Bioengineering, and Materials Science

May 10, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version