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Hypoimmune cells resist rejection in monkeys

October 24, 2023
in Science
Hypoimmune cells resist rejection in monkeys
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Genetic engineering to block immune destruction of transplanted cells succeeds in macaques.

A major challenge in the development of cell therapies is how to stop a patient’s immune response from killing transplanted cells derived from an unmatched donor. Various approaches to address this problem are under investigation, but a particularly elegant solution would be to create ‘universal’ donor cells that could be transplanted into any recipient without being rejected. In a study in Nature Biotechnology, Schrepfer and colleagues1 describe an exciting step toward this goal in a non-human primate model. Using donor cells with three genetic modifications — deletion of human leukocyte antigen (HLA) class I and II molecules and overexpression of CD47 — the authors demonstrate sustained immune evasion by human and macaque induced pluripotent stem cells (iPSCs) in immunocompetent rhesus macaques. This work is important because it is likely to pave the way to cell therapies that avoid immune rejection without the need for immunosuppression.

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Fig. 1: Cellular engineering to generate hypoimmune cells.

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Author information

Authors and Affiliations

Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Asuncion Borrero Borrego & Saar Gill

Salamanca Biomedical Institute (IBSAL), University of Salamanca, Salamanca, Spain

Asuncion Borrero Borrego

Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA

Saar Gill

Cellular Therapy and Transplantation, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA

Saar Gill

Corresponding author

Correspondence to
Saar Gill.

Ethics declarations

Competing interests

The authors declare no competing interests.

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Cite this article

Borrero Borrego, A., Gill, S. Hypoimmune cells resist rejection in monkeys.
Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02013-1

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Published: 23 October 2023

DOI: https://doi.org/10.1038/s41587-023-02013-1

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Tags: CellsHypoimmunescience
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