* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, October 18, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

    Elmira’s New Entertainment Venue ‘Centertown Social’ Adding its Final Touches – WENY News

    Elmira’s New Entertainment Venue ‘Centertown Social’ Adding its Final Touches – WENY News

    Bella Thorne Shows Off Her Toned Abs in Crop Top – Yahoo

    Bella Thorne Shows Off Her Toned Abs in a Chic Crop Top

    Bricktown continues to thrive as OKC’s entertainment district – OKC VeloCity

    Bricktown Shines as Oklahoma City’s Premier Entertainment Hotspot

    This Haunting ‘60s Country Song Is Even More Tragic Than You Remember – Yahoo

    This Haunting ’60s Country Song Will Break Your Heart All Over Again

    Arts/Entertainment: ‘Wait Until Dark’ brings spooky season center stage – Times Herald Online

    Wait Until Dark’ Delivers Chilling Thrills Perfect for the Spooky Season

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

    How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

    Guide to Proteomics Project Planning: Sample Preparation Strategies – Technology Networks

    Guide to Proteomics Project Planning: Sample Preparation Strategies – Technology Networks

    DLG−Agrifuture Concept Winners 2025 announced – Visionary Ideas in agricultural technology recognized – TheNewsMarket

    Meet the Visionary Innovators Revolutionizing Agricultural Technology in 2025

    Spanning the Gulf: Global Defence Technology 155 – Army Technology

    Spanning the Gulf: Exploring Cutting-Edge Global Defence Technology

    A Nobel Prize for explaining when technology leads to growth – NPR

    Nobel Prize Awarded for Unraveling How Technology Drives Economic Growth

    Erie Canal’s 200th anniversary: How a technological marvel for trade changed the environment forever – The Conversation

    Erie Canal’s 200th Anniversary: How a Trade Marvel Transformed the Environment Forever

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    CT Culture Corner: Robert Redford films to watch – CT Insider

    CT Culture Corner: Robert Redford films to watch – CT Insider

    Elmira’s New Entertainment Venue ‘Centertown Social’ Adding its Final Touches – WENY News

    Elmira’s New Entertainment Venue ‘Centertown Social’ Adding its Final Touches – WENY News

    Bella Thorne Shows Off Her Toned Abs in Crop Top – Yahoo

    Bella Thorne Shows Off Her Toned Abs in a Chic Crop Top

    Bricktown continues to thrive as OKC’s entertainment district – OKC VeloCity

    Bricktown Shines as Oklahoma City’s Premier Entertainment Hotspot

    This Haunting ‘60s Country Song Is Even More Tragic Than You Remember – Yahoo

    This Haunting ’60s Country Song Will Break Your Heart All Over Again

    Arts/Entertainment: ‘Wait Until Dark’ brings spooky season center stage – Times Herald Online

    Wait Until Dark’ Delivers Chilling Thrills Perfect for the Spooky Season

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

    How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

    Guide to Proteomics Project Planning: Sample Preparation Strategies – Technology Networks

    Guide to Proteomics Project Planning: Sample Preparation Strategies – Technology Networks

    DLG−Agrifuture Concept Winners 2025 announced – Visionary Ideas in agricultural technology recognized – TheNewsMarket

    Meet the Visionary Innovators Revolutionizing Agricultural Technology in 2025

    Spanning the Gulf: Global Defence Technology 155 – Army Technology

    Spanning the Gulf: Exploring Cutting-Edge Global Defence Technology

    A Nobel Prize for explaining when technology leads to growth – NPR

    Nobel Prize Awarded for Unraveling How Technology Drives Economic Growth

    Erie Canal’s 200th anniversary: How a technological marvel for trade changed the environment forever – The Conversation

    Erie Canal’s 200th Anniversary: How a Trade Marvel Transformed the Environment Forever

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Less stress boosts T cells as cancer fighters

September 23, 2023
in Science
Less stress boosts T cells as cancer fighters
Share on FacebookShare on Twitter

Researchers at the Salk Institute have found that even killer T cells, specialized immune cells that tirelessly seek and destroy cancer cells, can become exhausted. This exhaustion hinders their ability to fight cancer effectively. 

The study revealed a connection between this exhaustion and the body’s “fight-or-flight” stress response in different types of cancer, both in mice and human tissues. Interestingly, the researchers also discovered that this interaction between killer T cells and stress hormones can be blocked using beta-blocker drugs, commonly used to manage human blood pressure and heart rate. This breakthrough could lead to the development of more resilient cancer-fighting T cells.

The results, published in Nature on September 20, 2023, reveal a fresh connection between the body’s stress response and how the immune system deals with cancer. Moreover, they highlight the potential of combining beta-blocker medications with current immunotherapies to enhance cancer treatment by reinforcing killer T-cell activity.

Professor Susan Kaech, senior author and director of Salk’s NOMIS Center for Immunobiology and Microbial Pathogenesis, said, “There is no question immunotherapy has revolutionized cancer patient treatment, but there are many patients for whom it’s ineffective. Finding that our nervous system can suppress the function of cancer-destroying immune cells opens up new ways to think about rejuvenating T cells in tumors.”

The sympathetic nervous system handles our stress response, like in a “fight-or-flight” situation. Until now, we didn’t know much about how these nerves affect our immune response to infections or cancer.

The researchers looked at the sympathetic nerves that connect to our organs and release a hormone called noradrenaline, a stress hormone. They studied this in mice and human tissue samples, using different models for cancer and chronic illnesses to figure out how and when these nerves impact killer T cells.

The study discovered that sympathetic nerves were releasing a hormone called noradrenaline. This hormone was attached to killer T cells through a receptor called ADRB1. Exhausted killer T cells had more ADRB1 receptors than their active counterparts, allowing them to respond to the noradrenaline released by the nerves.

The researchers tried two approaches to block the interaction between noradrenaline and ADRB1 to see if they could prevent killer T-cell exhaustion. They either removed ADRB1 completely or impaired its function using beta-blocker drugs. Both methods resulted in more effective killer T cells that were better at destroying cancer cells.

Interestingly, the exhausted T cells didn’t just sense the nerves from a distance; they gathered around them in tissues. Surprisingly, the ADRB1 receptor provided instructions to the T cells, telling them to move closer to the nerves. This, in turn, suppressed their function, making them less effective at fighting cancer.

First author Anna-Maria Globig, a postdoctoral researcher in Kaech’s lab, said, “The innervation of tumors is an understudied area of tumor immunology. Our study has uncovered that nerves contribute to T cell exhaustion in tumors, where T cells become worn out and less powerful in their fight against the tumor over time. Suppose we can unravel how nerves suppress the body’s immune response to cancer and why the exhausted T cells move toward the nerves. In that case, we can target this process therapeutically.”

The researchers, led by Kaech, want to dig deeper into why stress negatively affects our health by studying exhausted killer T cells.

Image showing Exhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells without ADRB1 (red) do not surround the sympathetic nerves (yellow).Exhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells without ADRB1 (red) do not surround the sympathetic nerves (yellow).
Credit: Salk Institute

They’ve identified a new pathway that beta-blockers can target. This could help create more potent killer T cells that don’t get exhausted and can fight cancer more effectively, as explained by Globig.

Since beta-blockers are already used in clinics, the team plans to test this approach on lung cancer patients soon. They’ll collaborate with doctors to study more human cancer samples, giving them more data to support the idea that beta-blockers can be effective in cancer treatment.

Journal Reference:

Globig, AM., Zhao, S., Roginsky, J., et al. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. 10.1038/s41586-023-06568-6.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Tech Explorist – https://www.techexplorist.com/less-stress-boosts-t-cells-cancer-fighters/70708/#utm_source=rss&utm_medium=rss&utm_campaign=less-stress-boosts-t-cells-cancer-fighters

Tags: boostssciencestress
Previous Post

Model cuts costs, boosts generic drug availability

Next Post

Sand that flows uphill

Navigating Autonomy, Energy and Ecology in Ladakh, India – resilience.org

Navigating Autonomy, Energy and Ecology in Ladakh, India – resilience.org

October 18, 2025
Can We Save the AI Economy? – Towards Data Science

Can We Save the AI Economy? – Towards Data Science

October 18, 2025
Scientists discover surprising health impact of simple walk in park: ‘More efficient and stronger’ – Yahoo

Discover How a Simple Walk in the Park Can Transform Your Health and Strength

October 18, 2025
These Are Officially the 3 Best Tequilas of 2025, According to Concours Mondial de Bruxelles – Yahoo

These Are Officially the 3 Best Tequilas of 2025, According to Concours Mondial de Bruxelles – Yahoo

October 18, 2025
Italian Technology in Manufacturing: Supporting North American Industries and Keeping Production Local – Thomasnet

How Italian Technology is Revolutionizing North American Manufacturing and Boosting Local Production

October 18, 2025
This week in HS Sports: Separation is looming but common sense could still prevail – AL.com

High School Sports This Week: Tensions Flare, but Common Sense Could Prevail

October 18, 2025
Ball State Alumnus Alex Call on Dodgers Team Heading to World Series – Ball State University Athletics

Ball State Alumnus Alex Call Celebrates Dodgers’ Thrilling Journey to the World Series

October 18, 2025
Javier Milei’s economic policy in Argentina – GIS Reports

Javier Milei’s Bold Plan to Transform Argentina’s Economy

October 18, 2025
CT Culture Corner: Robert Redford films to watch – CT Insider

CT Culture Corner: Robert Redford films to watch – CT Insider

October 18, 2025
A Look Behind Routine Checkups with Our Animal Health Team – New England Aquarium

Discover What Happens During Routine Checkups with Our Animal Health Team

October 18, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (874)
  • Economy (895)
  • Entertainment (21,767)
  • General (17,669)
  • Health (9,936)
  • Lifestyle (908)
  • News (22,149)
  • People (896)
  • Politics (905)
  • Science (16,106)
  • Sports (21,395)
  • Technology (15,875)
  • World (878)

Recent News

Navigating Autonomy, Energy and Ecology in Ladakh, India – resilience.org

Navigating Autonomy, Energy and Ecology in Ladakh, India – resilience.org

October 18, 2025
Can We Save the AI Economy? – Towards Data Science

Can We Save the AI Economy? – Towards Data Science

October 18, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version