* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, August 2, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

LMAN1, the Unexpected Game-Changer in Allergy Treatment

June 20, 2023
in Science
LMAN1, the Unexpected Game-Changer in Allergy Treatment
Share on FacebookShare on Twitter

Pollen Allergies Hay Fever

Research identifies a previously unrecognized protein, LMAN1, which binds with common allergens to cause inflammatory reactions in allergic asthma. This potentially broad-spectrum discovery could redefine the treatment approach for allergic asthma and has been awarded a $1.5M grant by the National Institutes of Health for further investigation.

For those suffering from allergies, especially allergic asthma, springtime can be dreadful. Fortunately, UCF researcher Dr. Justine Tigno-Aranjuez is making breakthroughs that could one day make many common allergies a thing of the past.

For years, research and therapies for allergic asthma have been focused largely on targeting the inflammatory cytokines in the body that react to allergens and cause overproduction of mucus, wheezing, and difficulty breathing. Commonly prescribed drugs like Omalizumab, Dupilumab, Mepolizumab, and Reslizumab lower or block the various cytokines and antibodies responsible for the asthmatic response, but they work after a patient’s airway inflammation is well underway.

Dr. Tigno-Aranjuez wanted to find a new approach to keep allergen receptors from reacting in the first place. So she utilized a technique called LRC-TriCEPS – which identifies receptors in cells — for a common allergen, house dust mite.  The technology showed a cell protein called LMAN1 that had never before been recognized for having a role in the body’s allergen response.

Her findings were recently published in Cell Reports, her highest-impact paper to date.

“When we first had this discovery, we wanted to know, ‘What is this protein? What is already known about LMAN1 as an allergen receptor?’ and the interesting thing was that people had not been paying much attention to this protein in the context of allergy or allergic asthma,” she said.

Before her discovery, LMAN1 was generally known as a cargo receptor – a protein that transports other proteins inside and outside the cell.  However, Dr. Tigno-Aranjuez demonstrated that house dust mite allergens and LMAN1 can bind together on the cell surface to cause the inflammatory or allergic reaction.  Her research further showed that the binding depended on specific mannose sugar structures on the house dust mite allergens. This discovery has tremendous potential since many other common allergens, including pollen and fungi, are mannosylated, or modified by the addition of mannose sugars.

“Our thinking is that this could potentially not just be restricted to dust mites because many other allergens are mannosylated, this could be a very broad receptor that recognizes many different allergens,” she explained. “If you are thinking in terms of potential therapy, by understanding how LMAN1 recognizes dust mites and the consequences of such recognition, you could apply this to many other settings, and that is what we are currently trying to explore.”

The National Institutes of Health also saw potential with the UCF research, having just awarded Dr. Tigno-Aranjuez a $1.5M R01 grant to see if LMAN1 has a role in the expression of other mannosylated allergens.

Dr. Tigno-Aranjuez’s research on LMAN1 is performed in collaboration with the Cleveland Clinic. Dr. Bin Zhang, Associate Professor at the Lerner Research Institute, serves as co-investigator on this study. Dr. Zhang is considered an expert in LMAN1.

“LMAN 1 has been largely known as a protein that is involved in transporting proteins from inside cells to the outside of cells,” explained Dr. Zhang. “This research is the first one to show an entirely new function of LMAN1, as a receptor to bring proteins, such as allergens, from outside of cells to the inside. This could open up a new pathway for treatment.”

With hundreds of thousands of allergic asthma cases in the United States every year, and many more worldwide, this research represents a step forward toward helping these patients.

“Asthma is so prevalent that sometimes, people think, ‘We’ve already got a lot of treatments, we’ve got it covered.’ The reality is that we could always use more options, we could always improve upon existing treatments.” Said Dr. Tigno-Aranjuez. “Many treatments can only be prescribed if you meet certain clinical criteria, many treatments are cost prohibitive, many are not covered by insurance. So any new treatment we can put forth that could potentially be a more universal treatment would always be an advance.”

Dr. Tigno-Aranjuez and her team are now conducting research to confirm their hypothesis that other mannosylated allergens, such as pollen, are also recognized by LMAN1. If true, this could have broad implications in future therapies for many of the most common allergens.

Dr. Tigno-Aranjuez immigrated to the United States from the Philippines to conduct her graduate and postdoctoral training at Case Western University in Cleveland. She joined UCF in 2015 and focuses her research on immune signaling pathways involved in chronic inflammatory diseases such as asthma and Crohn’s disease.

Reference: “LMAN1 is a receptor for house dust mite allergens” by Madelyn H. Miller, Lindsay G. Swaby, Vanessa S. Vailoces, Maggie LaFratta, Yuan Zhang, Xiang Zhu, Dorilyn J. Hitchcock, Travis J. Jewett, Bin Zhang and Justine T. Tigno-Aranjuez, 3 March 2023, Cell Reports.
DOI: 10.1016/j.celrep.2023.112208

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/lman1-the-unexpected-game-changer-in-allergy-treatment/

Tags: Game-ChangerscienceUnexpected
Previous Post

Atomic “Breathing” – A New Building Block for Quantum Technology

Next Post

Skipping Evolution: The Kangaroos That Didn’t Hop

Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

August 2, 2025
New NIL guidance from College Sports Commission softens stance on collective payments to athletes – CBS Sports

New NIL guidance from College Sports Commission softens stance on collective payments to athletes – CBS Sports

August 2, 2025
Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees – Frontiers

Foraging strategy and tree structure as drivers of arboreality and suspensory behaviour in savannah-dwelling chimpanzees – Frontiers

August 2, 2025
EPA attacks climate science. Here are the facts. – E&E News by POLITICO

EPA Questions Climate Science: Key Insights You Shouldn’t Miss

August 2, 2025
6 science-backed strategies to improve your memory – National Geographic

6 Proven Science-Backed Strategies to Boost Your Memory

August 2, 2025
Trying to keep your brain young? A big new study finds these lifestyle changes help – NPR

Trying to keep your brain young? A big new study finds these lifestyle changes help – NPR

August 2, 2025
2025 World Junior Summer Showcase: 3 things learned on Day 5 – NHL.com

3 Must-Know Highlights from Day 5 of the 2025 World Junior Summer Showcase

August 2, 2025
Economic Reality Bites Trump and His Protectionist Trade Policies – The New Yorker

How Trump’s Protectionist Trade Policies Ended Up Hurting the Global Economy

August 2, 2025
Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

August 2, 2025
President Trump Delivers Remarks on Making Health Technology Great Again – The White House (.gov)

President Trump Delivers Remarks on Making Health Technology Great Again – The White House (.gov)

August 2, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (750)
  • Economy (775)
  • Entertainment (21,653)
  • General (16,243)
  • Health (9,812)
  • Lifestyle (783)
  • News (22,149)
  • People (776)
  • Politics (784)
  • Science (15,988)
  • Sports (21,271)
  • Technology (15,753)
  • World (758)

Recent News

Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

August 2, 2025
New NIL guidance from College Sports Commission softens stance on collective payments to athletes – CBS Sports

New NIL guidance from College Sports Commission softens stance on collective payments to athletes – CBS Sports

August 2, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version