* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, August 4, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Credo Technology: Wiring The AI Revolution (NASDAQ:CRDO) – Seeking Alpha

    Credo Technology: Driving the Next Wave of AI Innovation

    Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

    Microsoft Aims to Broaden Access to OpenAI Technology

    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Chicago Youth Symphony Orchestra takes the Lollapalooza stage – Yahoo Home

    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Credo Technology: Wiring The AI Revolution (NASDAQ:CRDO) – Seeking Alpha

    Credo Technology: Driving the Next Wave of AI Innovation

    Microsoft Seeks to Extend Access to OpenAI Technology – PYMNTS.com

    Microsoft Aims to Broaden Access to OpenAI Technology

    Livonia police use grappler technology to stop drunk driver – ClickOnDetroit | WDIV Local 4

    Livonia Police Deploy Grappler Technology to Safely Stop Drunk Driver

    Emory orthopaedic surgeons use robotic technology to transform knee replacement surgery – Emory News Center

    How Robotic Technology is Revolutionizing Knee Replacement Surgery

    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Mitochondria send SOS signals when under stress

August 1, 2023
in Science
Mitochondria send SOS signals when under stress
Share on FacebookShare on Twitter

Mitochondria are vital cellular organelles responsible for energy production through oxidative phosphorylation. However, during cellular stress, mitochondria may accumulate misfolded or damaged proteins, leading to proteotoxicity and impairing their proper function. The UPRmt is an essential cellular defense mechanism that aims to restore proteostasis in mitochondria.

Despite its significance, the precise signaling pathway from mitochondria to the nucleus during UPRmt activation remains an enigma. This study seeks to unravel the molecular mechanisms involved in the communication between mitochondria and the nucleus when mitochondria encounter stress, leading to the initiation of the UPRmt.

The study investigated at Goethe University Frankfurt how cells protect and repair their mitochondria, which are essential for cell function. The researchers found that when mitochondria experience stress, two signals are released in the cell’s cytosol (the fluid inside the cell). These signals are mitochondrial reactive oxygen species (mtROS) and accumulated mitochondrial protein precursors (c-mtProt). Both signals work together to activate a response called the mitochondrial unfolded protein response (UPRmt), which helps fix the damaged mitochondria.

The researchers discovered that mtROS in the cytosol causes specific proteins to change, and this, in turn, leads to the accumulation of c-mtProt. The combination of these signals activates a series of events that trigger the UPRmt, ultimately helping maintain the mitochondria’s health. This study provides valuable insights into how cells deal with stress-related issues in their mitochondria and how this process is regulated at the molecular level.

The study investigates how cells maintain the balance of proteins within mitochondria, the energy-producing organelles, under stressful conditions. During proteotoxic stress, mitochondria activate the mitochondrial unfolded protein response (UPRmt). This nuclear transcriptional response induces specific chaperones and proteases to restore mitochondrial protein balance.

The researchers aimed to understand the communication between mitochondria and the nucleus during UPRmt activation in human cells. They found that two signals, mitochondrial reactive oxygen species (mtROS) and accumulated mitochondrial protein precursors (c-mtProt), work together to initiate the UPRmt. While mtROS oxidizes a cytosolic protein, triggering the recruitment of chaperones to c-mtProt, the accumulation of c-m.

tProt signals UPRmt activation. Additionally, they discovered that ROS are crucial for UPRmt activation, as antioxidants inhibited UPRmt induction while increasing mtROS levels enhanced it. This research highlights the essential role of mtROS in signaling UPRmt. It deepens our understanding of how cells cope with mitochondrial stress.

The study focuses on how cells maintain the balance of proteins within mitochondria, the energy-producing organelles, during stressful conditions. They found that the Unfolded Protein Response in the mitochondria (UPRmt) is triggered by two signals: mitochondrial reactive oxygen species (mtROS) and accumulated mitochondrial protein precursors (c-mtProt) in the cytosol. These signals work together to activate a surveillance mechanism involving specific proteins (DNAJA1 and HSF1), which convey the stress information from mitochondria to the nucleus.

Communication leads to the activation of genes responsible for restoring proteostasis in mitochondria. The researchers confirmed that this mechanism is essential for coping with mitochondrial stress and maintaining cell viability. The study highlights a new understanding of how cells respond to mitochondrial stress, providing potential insights into addressing mitochondrial-related diseases.

Journal Reference:

Sutandy, F.X.R., Gößner, I., Tascher, G. et al. A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature. DOI:10.1038/s41586-023-06142-0.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Tech Explorist – https://www.techexplorist.com/mitochondria-send-sos-signals-under-stress/

Tags: MitochondriascienceSignals
Previous Post

Breakthrough achieved in Monte Carlo computer simulations

Next Post

The first bees evolved on an ancient supercontinent

New rule would expand tug escort requirements, reduce risk of oil spills in Puget Sound – Washington State Department of Ecology (.gov)

New Rule Strengthens Tug Escort Requirements to Drastically Reduce Oil Spill Risks in Puget Sound

August 4, 2025
100 years ago, scientists thought we’d be eating food made from air – Popular Science

A Century Ago, Scientists Predicted We’d Be Eating Food Made from Air

August 4, 2025
Maserati and Sparco Launch Lifestyle Capsule Inspired by Motorsport Heritage – stupidDOPE

Maserati and Sparco Launch Lifestyle Capsule Inspired by Motorsport Heritage – stupidDOPE

August 4, 2025
Fox News Flash top entertainment headlines of the week – Fox News

Top Entertainment Headlines You Can’t Miss This Week

August 4, 2025
How Is the Economy Doing Right Now? – NerdWallet

What’s Really Going On with the Economy Right Now?

August 4, 2025
Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

August 4, 2025
At Washington Health Care Authority, workers are warned of layoffs – Washington State Standard

Washington Health Care Authority Alerts Employees of Potential Layoffs

August 4, 2025
NYPD program allowed slain officer to moonlight as private security guard – Spectrum News NY1

NYPD program allowed slain officer to moonlight as private security guard – Spectrum News NY1

August 4, 2025
Credo Technology: Wiring The AI Revolution (NASDAQ:CRDO) – Seeking Alpha

Credo Technology: Driving the Next Wave of AI Innovation

August 3, 2025
Judge Halts Stephen F. Austin’s Female Sports Cuts Amid Title IX Suit – Sportico.com

Judge Halts Stephen F. Austin’s Female Sports Cuts Amid Title IX Suit – Sportico.com

August 3, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (753)
  • Economy (778)
  • Entertainment (21,655)
  • General (16,273)
  • Health (9,815)
  • Lifestyle (786)
  • News (22,149)
  • People (777)
  • Politics (787)
  • Science (15,991)
  • Sports (21,273)
  • Technology (15,755)
  • World (759)

Recent News

New rule would expand tug escort requirements, reduce risk of oil spills in Puget Sound – Washington State Department of Ecology (.gov)

New Rule Strengthens Tug Escort Requirements to Drastically Reduce Oil Spill Risks in Puget Sound

August 4, 2025
100 years ago, scientists thought we’d be eating food made from air – Popular Science

A Century Ago, Scientists Predicted We’d Be Eating Food Made from Air

August 4, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version