* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, September 17, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    PENN Entertainment stock rating reiterated at Market Outperform by JMP – Investing.com

    PENN Entertainment Stock Rated a Market Outperformer by Experts

    Here’s how NJ’s once-vibrant nightclub scene was born and why it died – Bergen Record

    The Rise and Fall of New Jersey’s Once-Vibrant Nightclub Scene: What Happened?

    The Emmys are back: Viewership soars to highest numbers in 4 years – yahoo.com

    The Emmys Return with a Bang: Viewership Hits a 4-Year High

    From Spinal Tap II to Ed Sheeran : your complete entertainment guide to the week ahead – The Guardian

    Fall’s Hottest Ski Films Are Going on Tour—Here’s the List – yahoo.com

    Experience the Thrill: Fall’s Hottest Ski Films Hit the Road-Don’t Miss the Tour!

    Ryan Reynolds reveals he called a journalist who said mean things about John Candy – yahoo.com

    Ryan Reynolds Reveals the Moment He Stood Up to a Journalist Who Insulted John Candy

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    City IT presented Best of North Carolina Technology Award – RaleighNC.gov

    City IT Honored with Best of North Carolina Technology Award

    LELO Releases 2025 Futurist Report: Intergenerational Views on Relationships, Sex, and Technology – PR Newswire

    Exploring the Future: How Different Generations View Relationships, Sex, and Technology in 2025

    Will New Big Technology Engagements Reshape Innodata’s Growth Path? – Yahoo Finance

    Could New Major Tech Partnerships Propel Innodata to Unprecedented Growth?

    Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

    Billion-dollar coffins? New technology could make oceans transparent and Aukus submarines vulnerable – The Guardian

    Billion-Dollar Coffins? How New Technology Could Make Oceans Transparent and Expose Submarines

    What if artificial intelligence is just a “normal” technology? – The Economist

    What if artificial intelligence is just a “normal” technology? – The Economist

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    PENN Entertainment stock rating reiterated at Market Outperform by JMP – Investing.com

    PENN Entertainment Stock Rated a Market Outperformer by Experts

    Here’s how NJ’s once-vibrant nightclub scene was born and why it died – Bergen Record

    The Rise and Fall of New Jersey’s Once-Vibrant Nightclub Scene: What Happened?

    The Emmys are back: Viewership soars to highest numbers in 4 years – yahoo.com

    The Emmys Return with a Bang: Viewership Hits a 4-Year High

    From Spinal Tap II to Ed Sheeran : your complete entertainment guide to the week ahead – The Guardian

    Fall’s Hottest Ski Films Are Going on Tour—Here’s the List – yahoo.com

    Experience the Thrill: Fall’s Hottest Ski Films Hit the Road-Don’t Miss the Tour!

    Ryan Reynolds reveals he called a journalist who said mean things about John Candy – yahoo.com

    Ryan Reynolds Reveals the Moment He Stood Up to a Journalist Who Insulted John Candy

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    City IT presented Best of North Carolina Technology Award – RaleighNC.gov

    City IT Honored with Best of North Carolina Technology Award

    LELO Releases 2025 Futurist Report: Intergenerational Views on Relationships, Sex, and Technology – PR Newswire

    Exploring the Future: How Different Generations View Relationships, Sex, and Technology in 2025

    Will New Big Technology Engagements Reshape Innodata’s Growth Path? – Yahoo Finance

    Could New Major Tech Partnerships Propel Innodata to Unprecedented Growth?

    Unlocking AI Success: How People, Process, and Technology Form the Ultimate Triangle

    Billion-dollar coffins? New technology could make oceans transparent and Aukus submarines vulnerable – The Guardian

    Billion-Dollar Coffins? How New Technology Could Make Oceans Transparent and Expose Submarines

    What if artificial intelligence is just a “normal” technology? – The Economist

    What if artificial intelligence is just a “normal” technology? – The Economist

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Nasal Spray Demonstrates Significant Success in Treating Depression

December 5, 2023
in Science
Nasal Spray Demonstrates Significant Success in Treating Depression
Share on FacebookShare on Twitter

Depression Relief Concept

A recent study found esketamine nasal spray to be more effective than quetiapine extended-release in treating treatment-resistant depression, offering new hope for effective management of this challenging condition.

Severe depression and treatment-resistant depression (TRD) are prevalent conditions. About one-third of patients show no improvement with standard treatments like selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). TRD contributes to a higher incidence of other health issues, an increased likelihood of suicide attempts, and completions, higher overall mortality, and more frequent hospital admissions.

In addition, the relapse rate among those affected is high, highlighting the need for effective and targeted therapies for TRD. Janssen Pharmaceutical Companies of Johnson & Johnson has recently completed an international randomized Phase IIIb study in scientific collaboration with University Hospital Frankfurt. The study compared the drugs and dosage forms of two combination therapies: One group was treated with SSRI/SNRIs in combination with esketamine nasal spray.

In the comparison group, SSRI/SNRIs were administered together with quetiapine extended-release, as recommended by the National Disease Management Guideline on Unipolar Depression. The researchers established that the efficacy of esketamine nasal spray was superior in achieving remission at Week 8 (while still on study treatment) and in remaining relapse-free through Week 32 after remission at Week 8 (while still on study treatment) in patients who have TRD when both treatments were taken in combination with a continuing SSRI/SNRI.

Enhanced pharmacological effect

“If a patient does not show any improvement after two different antidepressant therapies over several weeks, we call this treatment-resistant depression or TRD. Studies have shown that administering an additional drug can then be effective,” explains Professor Andreas Reif, Principal Investigator in the study, first author of the primary manuscript now published and director of the Department of Psychiatry, Psychosomatics and Psychotherapy at University Hospital Frankfurt.

“In the first instance, such an added drug does not need to have an antidepressant effect, but it can often improve or enhance the effect in combination with the previous SSRI or SNRI therapy. This is what was done in the comparison arm, using quetiapine XR in addition to ongoing SSRI/SNRI treatment.”

Esketamine, as known from Anesthesiology, has an analgesic effect, but at doses used here and with the kinetics of application through a nasal spray, it also has a distinct antidepressant effect, which is thought to happen through counteraction of reduced neuronal plasticity in the brain, which is generally observed in patients with TRD.

27.1 percent of patients in the esketamine nasal spray arm, who had on average been ill for over a year, went into remission at Week 8 while on study treatment, that is, experienced improvement to the extent that their depression severity reached the non-depressed range. In the quetiapine extended-release study arm, only 17.6 percent who achieved remission at Week 8. Both treatments were taken in combination with a continuing SSRI/ SNRI.

Retaining the edge with esketamine

Esketamine nasal spray is already used as a potent antidepressant. In previous studies, however, it was only compared in combination with a newly started SSRI/SNRI antidepressant therapy together with a placebo nasal spray, where it was already clear that the efficacy in the esketamine nasal spray group was significantly superior to that in the placebo group.

In the study published in the NEJM, quetiapine extended-release tablets serve as the comparator because they are already used for augmentation therapy and are also recommended in the guidelines.

“In the group receiving esketamine nasal spray were 54% relatively more patients to experience remission at Week 8 than those receiving quetiapine extended-release. This is a good result for a group with treatment-resistant depression, that is, who have a poor prognosis,” says Profesor Reif. “In the relapse rate, too, which we monitored after six months, those patients treated with esketamine retained the edge over those treated with quetiapine.”

About the ESCAPE-TRD Ph 3b study

The Janssen Pharmaceutical Companies of Johnson & Johnson, respectively the Belgium-based affiliate, Janssen Pharmaceutica NV, was responsible for designing and coordinating the study. Scientists from Janssen’s research departments in several European countries and the US made a significant contribution to implementing the study.

A total of 171 facilities took part in the open-label, randomized, rater-blinded and multicenter study. Hospitals, inpatient and outpatient departments as well as research centers in 24 countries were able to incorporate almost 700 patients in the study. Alongside the Department of Psychiatry, Psychosomatics and Psychotherapy at University Hospital Frankfurt, the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP in Frankfurt was also involved. The joint objective was to assess the efficacy, safety and tolerability of esketamine nasal spray in comparison to quetiapine extended-release, both in combination with ongoing SSRI/SNRI therapy, in patients with TRD. As predicted and hoped, patients in the esketamine nasal spray study arm showed better results across the study endpoints.

Reference: “Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression” by Andreas Reif, Istvan Bitter, Jozefien Buyze, Kerstin Cebulla, Richard Frey, Dong-Jing Fu, Tetsuro Ito, Yerkebulan Kambarov, Pierre-Michel Llorca, Albino J. Oliveira-Maia, Thomas Messer, Siobhán Mulhern-Haughey, Benoît Rive, Christian von Holt, Allan H. Young and Yordan Godinov, 3 October 2023, New England Journal of Medicine.
DOI: 10.1056/NEJMoa2304145

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/nasal-spray-demonstrates-significant-success-in-treating-depression/

Tags: Nasalsciencespray
Previous Post

“Unusually Massive” – Astronomers Discover a Planet That Shouldn’t Exist

Next Post

The Heat Is On: Thermal Anomalies Detected in Ethiopia’s “Gateway to Hell”

Torch Lake faces ecological challenges from invasive Quagga Mussels – WPBN

Torch Lake Fights Back Against the Growing Threat of Invasive Quagga Mussels

September 17, 2025
New Data Science Minor Prepares Students for Data-Driven World – CSUF News

Unlock Your Potential with the Exciting New Data Science Minor Designed for a Data-Driven Future

September 17, 2025
Miami University’s Cleveland Clinic Health Sciences and Wellness facility. – Cleveland Clinic Newsroom

Explore Miami University’s Exciting New Cleveland Clinic Health Sciences and Wellness Center

September 17, 2025
This Is The Most Popular Soup In The U.S. Right Now—And It’s A Fall Classic – yahoo.com

This Fall’s Most Beloved Soup Is Taking the U.S. by Storm

September 17, 2025
City IT presented Best of North Carolina Technology Award – RaleighNC.gov

City IT Honored with Best of North Carolina Technology Award

September 17, 2025

Lillie C. Ainscough – altoonamirror.com

September 17, 2025
World Athletics Championships: Faith Kipyegon storms to historic fourth 1500m title in Tokyo – BBC

Faith Kipyegon Makes History with Stunning Fourth 1500m Title at World Athletics Championships in Tokyo

September 17, 2025
What Jamie Dimon and other bank CEOs are saying about the economy – Quartz

What Jamie Dimon and Leading Bank CEOs Are Unveiling About the Future of the Economy

September 17, 2025
PENN Entertainment stock rating reiterated at Market Outperform by JMP – Investing.com

PENN Entertainment Stock Rated a Market Outperformer by Experts

September 16, 2025
While Michigan sees improvements in childhood health, education outcomes raise concerns – Michigan Advance

Michigan Makes Strides in Childhood Health, But Education Outcomes Spark Concern

September 16, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (823)
  • Economy (842)
  • Entertainment (21,721)
  • General (17,081)
  • Health (9,887)
  • Lifestyle (857)
  • News (22,149)
  • People (847)
  • Politics (852)
  • Science (16,054)
  • Sports (21,343)
  • Technology (15,825)
  • World (826)

Recent News

Torch Lake faces ecological challenges from invasive Quagga Mussels – WPBN

Torch Lake Fights Back Against the Growing Threat of Invasive Quagga Mussels

September 17, 2025
New Data Science Minor Prepares Students for Data-Driven World – CSUF News

Unlock Your Potential with the Exciting New Data Science Minor Designed for a Data-Driven Future

September 17, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version