* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Tuesday, July 1, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

    Ostin Technology (OST): Volatility’s Warning or Contrarian Opportunity? – AInvest

    Ostin Technology (OST): Navigating Market Volatility – Red Flag or Hidden Opportunity?

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    A Secret Society, Ritualistic Killings, and a Century-Old Curse Netflix and YRF Entertainment’s ‘Mandala Murders’ Premieres July 25 – About Netflix

    A Secret Society, Ritualistic Killings, and a Century-Old Curse: Dive into the Chilling World of ‘Mandala Murders’ Premiering July 25

    Susquehanna Raises Penn Entertainment Inc. (PENN) Price Target. – Yahoo Finance

    Susquehanna Raises Price Target for Penn Entertainment Inc. (PENN)

    George Lopez is coming to Spokane – KXLY.com

    George Lopez is coming to Spokane – KXLY.com

    Netflix unveils Dallas immersive venue for fans of hit shows like ‘Squid Game,’ ‘Stranger Things’ – Houston Chronicle

    Step Inside Netflix’s New Dallas Immersive Experience Featuring Hits Like ‘Squid Game’ and ‘Stranger Things

    ‘Puttin’ on the Ritz’: Civic Players bring ‘Young Frankenstein’ to life – Yahoo

    Civic Players Deliver a Hilarious and Unforgettable Performance of ‘Young Frankenstein

    ‘Wheel of Fortune’: Amputee Wins $60,000 After Breaking Incredible ‘Curse’ – Hastings Tribune

    Wheel of Fortune’ Amputee Breaks Incredible ‘Curse’ to Win $60,000!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Owls inspire new revolutionary noise reduction technology – KTEN

    Owls inspire new revolutionary noise reduction technology – KTEN

    New center coming to Mizzou will focus on energy research and technology – Columbia Missourian

    Mizzou Launches Innovative New Center Dedicated to Energy Research and Technology

    Mirrors in space and underwater curtains: can technology buy us enough time to save the Arctic ice caps? – The Guardian

    Can Technology Like Space Mirrors and Underwater Curtains Buy Us Time to Save the Arctic Ice Caps?

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Naples restaurant owner prepares for hurricane season with new flood technology – Fox4Now.com

    Emerging Memory and Storage Technology Market Analysis Report 2025-2034 | AI and HPC Boom Fuels Surging Demand for Fast, Low-Power Memory Devices – Yahoo Finance

    How AI and HPC Are Driving Explosive Growth in Fast, Low-Power Memory Technologies Through 2034

    Ostin Technology (OST): Volatility’s Warning or Contrarian Opportunity? – AInvest

    Ostin Technology (OST): Navigating Market Volatility – Red Flag or Hidden Opportunity?

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Nasal Spray Demonstrates Significant Success in Treating Depression

December 5, 2023
in Science
Nasal Spray Demonstrates Significant Success in Treating Depression
Share on FacebookShare on Twitter

Depression Relief Concept

A recent study found esketamine nasal spray to be more effective than quetiapine extended-release in treating treatment-resistant depression, offering new hope for effective management of this challenging condition.

Severe depression and treatment-resistant depression (TRD) are prevalent conditions. About one-third of patients show no improvement with standard treatments like selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). TRD contributes to a higher incidence of other health issues, an increased likelihood of suicide attempts, and completions, higher overall mortality, and more frequent hospital admissions.

In addition, the relapse rate among those affected is high, highlighting the need for effective and targeted therapies for TRD. Janssen Pharmaceutical Companies of Johnson & Johnson has recently completed an international randomized Phase IIIb study in scientific collaboration with University Hospital Frankfurt. The study compared the drugs and dosage forms of two combination therapies: One group was treated with SSRI/SNRIs in combination with esketamine nasal spray.

In the comparison group, SSRI/SNRIs were administered together with quetiapine extended-release, as recommended by the National Disease Management Guideline on Unipolar Depression. The researchers established that the efficacy of esketamine nasal spray was superior in achieving remission at Week 8 (while still on study treatment) and in remaining relapse-free through Week 32 after remission at Week 8 (while still on study treatment) in patients who have TRD when both treatments were taken in combination with a continuing SSRI/SNRI.

Enhanced pharmacological effect

“If a patient does not show any improvement after two different antidepressant therapies over several weeks, we call this treatment-resistant depression or TRD. Studies have shown that administering an additional drug can then be effective,” explains Professor Andreas Reif, Principal Investigator in the study, first author of the primary manuscript now published and director of the Department of Psychiatry, Psychosomatics and Psychotherapy at University Hospital Frankfurt.

“In the first instance, such an added drug does not need to have an antidepressant effect, but it can often improve or enhance the effect in combination with the previous SSRI or SNRI therapy. This is what was done in the comparison arm, using quetiapine XR in addition to ongoing SSRI/SNRI treatment.”

Esketamine, as known from Anesthesiology, has an analgesic effect, but at doses used here and with the kinetics of application through a nasal spray, it also has a distinct antidepressant effect, which is thought to happen through counteraction of reduced neuronal plasticity in the brain, which is generally observed in patients with TRD.

27.1 percent of patients in the esketamine nasal spray arm, who had on average been ill for over a year, went into remission at Week 8 while on study treatment, that is, experienced improvement to the extent that their depression severity reached the non-depressed range. In the quetiapine extended-release study arm, only 17.6 percent who achieved remission at Week 8. Both treatments were taken in combination with a continuing SSRI/ SNRI.

Retaining the edge with esketamine

Esketamine nasal spray is already used as a potent antidepressant. In previous studies, however, it was only compared in combination with a newly started SSRI/SNRI antidepressant therapy together with a placebo nasal spray, where it was already clear that the efficacy in the esketamine nasal spray group was significantly superior to that in the placebo group.

In the study published in the NEJM, quetiapine extended-release tablets serve as the comparator because they are already used for augmentation therapy and are also recommended in the guidelines.

“In the group receiving esketamine nasal spray were 54% relatively more patients to experience remission at Week 8 than those receiving quetiapine extended-release. This is a good result for a group with treatment-resistant depression, that is, who have a poor prognosis,” says Profesor Reif. “In the relapse rate, too, which we monitored after six months, those patients treated with esketamine retained the edge over those treated with quetiapine.”

About the ESCAPE-TRD Ph 3b study

The Janssen Pharmaceutical Companies of Johnson & Johnson, respectively the Belgium-based affiliate, Janssen Pharmaceutica NV, was responsible for designing and coordinating the study. Scientists from Janssen’s research departments in several European countries and the US made a significant contribution to implementing the study.

A total of 171 facilities took part in the open-label, randomized, rater-blinded and multicenter study. Hospitals, inpatient and outpatient departments as well as research centers in 24 countries were able to incorporate almost 700 patients in the study. Alongside the Department of Psychiatry, Psychosomatics and Psychotherapy at University Hospital Frankfurt, the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP in Frankfurt was also involved. The joint objective was to assess the efficacy, safety and tolerability of esketamine nasal spray in comparison to quetiapine extended-release, both in combination with ongoing SSRI/SNRI therapy, in patients with TRD. As predicted and hoped, patients in the esketamine nasal spray study arm showed better results across the study endpoints.

Reference: “Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression” by Andreas Reif, Istvan Bitter, Jozefien Buyze, Kerstin Cebulla, Richard Frey, Dong-Jing Fu, Tetsuro Ito, Yerkebulan Kambarov, Pierre-Michel Llorca, Albino J. Oliveira-Maia, Thomas Messer, Siobhán Mulhern-Haughey, Benoît Rive, Christian von Holt, Allan H. Young and Yordan Godinov, 3 October 2023, New England Journal of Medicine.
DOI: 10.1056/NEJMoa2304145

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/nasal-spray-demonstrates-significant-success-in-treating-depression/

Tags: Nasalsciencespray
Previous Post

“Unusually Massive” – Astronomers Discover a Planet That Shouldn’t Exist

Next Post

The Heat Is On: Thermal Anomalies Detected in Ethiopia’s “Gateway to Hell”

Who would be affected by health care cuts in Senate version of Trump’s budget bill – PBS

Who Will Be Hit Hardest by Health Care Cuts in the Senate’s Trump Budget Plan?

July 1, 2025
Senate passes Trump’s reconciliation bill with Vance casting tie-breaking vote – PBS

Senate Passes Trump’s Reconciliation Bill After Vance Casts Decisive Tie-Breaking Vote

July 1, 2025
Groundbreaking technology to help police tackle violence against women – The Independent

Revolutionary Technology Transforms the Fight Against Violence Toward Women

July 1, 2025
Apple Inc. (AAPL) Adds Tennis To Its List of Supported Sports Ahead of Wimbledon – Yahoo Finance

Apple Inc. (AAPL) Adds Tennis To Its List of Supported Sports Ahead of Wimbledon – Yahoo Finance

July 1, 2025
Nature’s headlamps: A unique light-focusing structure in Parasesarma de Man, 1895 mangrove crabs – ESA Journals

Nature’s headlamps: A unique light-focusing structure in Parasesarma de Man, 1895 mangrove crabs – ESA Journals

July 1, 2025
Scientists found what just might be Earth’s oldest rocks – Boy Genius Report

Scientists found what just might be Earth’s oldest rocks – Boy Genius Report

July 1, 2025
The EU must show leadership and stand up for science, health and women’s rights – The Parliament Magazine

Why the EU Needs to Take the Lead in Protecting Science, Health, and Women’s Rights

July 1, 2025
Anna Rossi Returns to Broadcast Television with Boston 25, Launching New Lifestyle Series Ahead of July 4th Holiday – PR Newswire

Anna Rossi’s Triumphant Return to Broadcast TV: Don’t Miss Her Exciting New Lifestyle Series Launching Just in Time for July 4th!

July 1, 2025
Chelsea win Club World Cup’s most absurd game yet – ESPN

Chelsea Triumphs in the Most Bizarre Club World Cup Match Ever

July 1, 2025
Analysis: China’s Economy and Its Influence on Global Markets – U.S. Bank

How China’s Economy is Shaping the Future of Global Markets

July 1, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (701)
  • Economy (725)
  • Entertainment (21,615)
  • General (15,653)
  • Health (9,766)
  • Lifestyle (731)
  • News (22,149)
  • People (726)
  • Politics (733)
  • Science (15,943)
  • Sports (21,223)
  • Technology (15,710)
  • World (706)

Recent News

Who would be affected by health care cuts in Senate version of Trump’s budget bill – PBS

Who Will Be Hit Hardest by Health Care Cuts in the Senate’s Trump Budget Plan?

July 1, 2025
Senate passes Trump’s reconciliation bill with Vance casting tie-breaking vote – PBS

Senate Passes Trump’s Reconciliation Bill After Vance Casts Decisive Tie-Breaking Vote

July 1, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version