* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, August 11, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    This LA singer performed at Trump casinos. Now he’s a retired bus driver in Acadiana. – The Advocate

    This LA singer performed at Trump casinos. Now he’s a retired bus driver in Acadiana. – The Advocate

    Six Flags Entertainment Corporation Reports 2025 Second Quarter Results, Provides July Performance Update, and Updates Full-Year Guidance – Business Wire

    Six Flags Reveals Thrilling Q2 2025 Results, Shares July Highlights, and Updates Full-Year Outlook

    ‘Paying homage to Kansas’: Singer-songwriter Dallas Pryor shares music journey – The Topeka Capital-Journal

    Honoring Kansas: Singer-Songwriter Dallas Pryor Shares His Inspiring Musical Journey

    Alabama expands entertainment incentives to boost state’s music and creative industries – Made in Alabama

    Alabama Supercharges Entertainment Incentives to Spark Explosive Growth in Music and Creative Industries

    Peacock’s Biggest Action Show Streams 2 New Episodes Sooner Than You Think – yahoo.com

    Peacock’s Hottest Action Show Drops 2 New Episodes Sooner Than Expected!

    Themed Entertainment Design – Purdue Polytechnic

    Innovative Themed Entertainment Design: Creating Immersive Experiences

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Gas-to-liquids technology can support national resilience – The Strategist | ASPI’s analysis and commentary site

    Unlocking National Strength: How Gas-to-Liquids Technology Drives Resilience

    Micron Technology (MU) Launched a New Memory Chip for Space Application – Yahoo Finance

    Micron Technology Launches Revolutionary Memory Chip Built for Space Exploration

    United Airlines passengers in US delayed after tech glitch halts flights – BBC

    United Airlines passengers in US delayed after tech glitch halts flights – BBC

    Preparing Students for the Technology of Tomorrow – Drug Topics

    Preparing Students Today to Thrive in Tomorrow’s Tech-Driven World

    Technology, History, and Summer Camp at the Rhode Island Computer Museum – abc6.com

    Discover Technology, History, and Summer Camp Adventures at the Rhode Island Computer Museum

    MBU showcases student work at Occupational Therapy Technology Fair – WHSV

    Discover the Most Innovative Student Projects at the Occupational Therapy Technology Fair

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    This LA singer performed at Trump casinos. Now he’s a retired bus driver in Acadiana. – The Advocate

    This LA singer performed at Trump casinos. Now he’s a retired bus driver in Acadiana. – The Advocate

    Six Flags Entertainment Corporation Reports 2025 Second Quarter Results, Provides July Performance Update, and Updates Full-Year Guidance – Business Wire

    Six Flags Reveals Thrilling Q2 2025 Results, Shares July Highlights, and Updates Full-Year Outlook

    ‘Paying homage to Kansas’: Singer-songwriter Dallas Pryor shares music journey – The Topeka Capital-Journal

    Honoring Kansas: Singer-Songwriter Dallas Pryor Shares His Inspiring Musical Journey

    Alabama expands entertainment incentives to boost state’s music and creative industries – Made in Alabama

    Alabama Supercharges Entertainment Incentives to Spark Explosive Growth in Music and Creative Industries

    Peacock’s Biggest Action Show Streams 2 New Episodes Sooner Than You Think – yahoo.com

    Peacock’s Hottest Action Show Drops 2 New Episodes Sooner Than Expected!

    Themed Entertainment Design – Purdue Polytechnic

    Innovative Themed Entertainment Design: Creating Immersive Experiences

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Gas-to-liquids technology can support national resilience – The Strategist | ASPI’s analysis and commentary site

    Unlocking National Strength: How Gas-to-Liquids Technology Drives Resilience

    Micron Technology (MU) Launched a New Memory Chip for Space Application – Yahoo Finance

    Micron Technology Launches Revolutionary Memory Chip Built for Space Exploration

    United Airlines passengers in US delayed after tech glitch halts flights – BBC

    United Airlines passengers in US delayed after tech glitch halts flights – BBC

    Preparing Students for the Technology of Tomorrow – Drug Topics

    Preparing Students Today to Thrive in Tomorrow’s Tech-Driven World

    Technology, History, and Summer Camp at the Rhode Island Computer Museum – abc6.com

    Discover Technology, History, and Summer Camp Adventures at the Rhode Island Computer Museum

    MBU showcases student work at Occupational Therapy Technology Fair – WHSV

    Discover the Most Innovative Student Projects at the Occupational Therapy Technology Fair

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

New Discovery Could “Unlock” the Future of Cancer Treatment

October 7, 2023
in Science
New Discovery Could “Unlock” the Future of Cancer Treatment
Share on FacebookShare on Twitter

Natural Killer Cell Destorying Cancer Cell Illustration

Researchers have discovered a ‘guard mechanism’ in the protein GBP1 that regulates its ability to attack microbes in infected cells. This discovery explores the interaction between GBP1 and PIM1 and has implications for potential treatments against diseases like Toxoplasma, Chlamydia, Tuberculosis, and cancer. The control mechanism, likened to a “lock and key” system, could offer innovative therapeutic interventions.

The attack protein guard mechanism can be used to kill pathogens like Toxoplasma and cancer cells.

Researchers have identified a ‘guard mechanism’ for GBP1, a protein known for targeting microbes within infected cells. This groundbreaking discovery could pave the way for innovative treatments against diseases such as Toxoplasma, Chlamydia, Tuberculosis, and even cancer.

A recent study spearheaded by the University of Birmingham and published in the journal Science has discovered the lock and key mechanism that controls the attack protein GPB1. GBP1 is activated during inflammation and has the potential to attack membranes within cells and destroy them.

Lock and Key Mechanism

This research has uncovered that GBP1’s activity is managed through phosphorylation – a procedure in which a phosphate group is added to a protein by enzymes called protein kinases. The kinase targeting GBP1 is called PIM1 and can also become activated during inflammation. Phosphorylated GBP1 in turn is bound to a scaffold protein, which keeps uninfected bystander cells safe from uncontrolled GBP1 membrane attack and cell death.

The newly discovered mechanism prevents GPB1 from attacking cell membranes indiscriminately, creating a guard mechanism that is sensitive to disruption by the actions of pathogens inside the cells. The new discovery was made by Daniel Fisch, a former Ph.D. student in the Frickel lab working on the study.

Dr Daniel Fisch said: “This was a fantastic project to work on for the past six years and involved many research groups from all over the world. None of this would have been possible without help from our colleagues and friends at The Francis Crick Institute in London, EMBL in Grenoble (France), ETH Zurich (Switzerland), and Osaka University (Japan).”

Implications and Future Research

Dr Eva Frickel, Senior Wellcome Trust Fellow at the University of Birmingham, who led the study explained: “This discovery is significant for several reasons. Firstly, guard mechanisms such as the one that controls GBP1 were known to exist in plant biology, but less so in mammals. Think of it as a lock and key system. GPB1 wants to go out and attack cellular membranes, but PIM1 is the key meaning GPB1 is locked safely away.“

“The second reason is that this discovery could have multiple therapeutic applications. Now we know how GBP1 is controlled, we can explore ways to switch this function on and off at will, using it to kill pathogens.”

Dr Frickel and her team conducted this initial research on Toxoplasma gondii, a single-celled parasite that is common in cats. Whilst Toxoplasma infections in Europe and Western countries are unlikely to cause serious illness, in South American countries it can cause reoccurring eye infections and blindness and is particularly dangerous for pregnant women.

The researchers found that Toxoplasma blocks inflammatory signaling within cells, preventing PIM1 from being produced, meaning that the “lock and key” system disappears, liberating GBP1 to attack the parasite. Switching PIM1 ‘off’ with an inhibitor or by manipulating the cell’s genome also resulted in GPB1 attacking Toxoplasma and removing the infected cells.

Dr Frickel continued: “This mechanism could also work on other pathogens, such as Chlamydia, Mycobacterium tuberculosis, and Staphylococcus all major disease-causing pathogens that are increasingly becoming more resistant to antibiotics. By controlling the guard mechanism, we could use the attack protein to eliminate the pathogens in the body. We have already begun looking at this opportunity to see if we are able to replicate what we saw in our Toxoplasma experiments. We are also incredibly excited about how this could be used to kill cancer cells.”

PIM1 is a key molecule in the survival of cancer cells, while GPB1 is activated by the inflammatory effect of cancer. The researchers think that by blocking the interaction between PIM1 and GPB1 they could specifically eliminate cancer cells.

Dr Frickel said: “The implication for cancer treatment is huge. We think this guard mechanism is active in cancer cells, so the next step is to explore this and see if we can block the guard and selectively eliminate cancer cells. There is an inhibitor on the market that we used to disrupt PIM1 and GPB1 interaction. So, if this works, you could use this drug to unlock GPB1 and attack the cancer cells. There is still a very long way to go, but the discovery of the PIM1 guard mechanism could be a massive first step in finding new ways to treat cancer and increasingly antibiotic-resistant pathogens.”

Reference: “PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection” by Daniel Fisch, Moritz M. Pfleiderer, Eleni Anastasakou, Gillian M. Mackie, Fabian Wendt, Xiangyang Liu, Barbara Clough, Samuel Lara-Reyna, Vesela Encheva, Ambrosius P. Snijders, Hironori Bando, Masahiro Yamamoto, Andrew D. Beggs, Jason Mercer, Avinash R. Shenoy, Bernd Wollscheid, Kendle M. Maslowski, Wojtek P. Galej and Eva-Maria Frickel, 6 October 2023, Science.
DOI: 10.1126/science.adg2253

The study was funded by the Wellcome Trust. 

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/new-discovery-could-unlock-the-future-of-cancer-treatment/

Tags: CouldDiscoveryscience
Previous Post

Frozen in the Fast Lane: Jet Stream Pattern Locks in Extreme Winter Cold Spells

Next Post

Should We Cut Down All the Oak Trees? The Unexpected Link Between Trees and Air Pollution

Plastisphere provides a unique ecological niche for microorganisms in Zostera marina seagrass meadows – Nature

Plastisphere provides a unique ecological niche for microorganisms in Zostera marina seagrass meadows – Nature

August 11, 2025
‘The best solution is to murder him in his sleep’: AI models can send subliminal messages that teach other AIs to be ‘evil,’ study claims – Live Science

AI Models Could Be Secretly Teaching Each Other to Behave ‘Evil’ Through Subliminal Messages, Study Warns

August 11, 2025
Concerns Emerge Over Potential Cancer Links to Drugs Like Ozempic – ScienceAlert

Concerns Emerge Over Potential Cancer Links to Drugs Like Ozempic – ScienceAlert

August 11, 2025
Exploring the Links Between Demographics, Lifestyle, Comorbidities, Prediabetes, and Mortality – BIOENGINEER.ORG

How Demographics, Lifestyle, and Health Conditions Shape Prediabetes and Mortality Risk

August 11, 2025
Gas-to-liquids technology can support national resilience – The Strategist | ASPI’s analysis and commentary site

Unlocking National Strength: How Gas-to-Liquids Technology Drives Resilience

August 11, 2025
From the Texas offensive line to Michigan RB room, these non-QB questions need answers ahead of 2025 season – CBS Sports

Crucial Position Battles from Texas’ Offensive Line to Michigan’s Running Backs That Will Define the 2025 Season

August 11, 2025
Activists plant war protest doll inside Disneyland – SFGATE

Activists Ignite Outrage by Planting War Protest Doll Inside Disneyland

August 11, 2025
Trump, when in trouble, throws tantrums. The economy is his latest conniption. | Opinion – USA Today

Trump, when in trouble, throws tantrums. The economy is his latest conniption. | Opinion – USA Today

August 11, 2025
This LA singer performed at Trump casinos. Now he’s a retired bus driver in Acadiana. – The Advocate

This LA singer performed at Trump casinos. Now he’s a retired bus driver in Acadiana. – The Advocate

August 11, 2025
Laramie County health and food inspections (8/1/25–8/7/25) – Cap City News

Laramie County Health and Food Inspections: Key Findings from August 1-7, 2025

August 11, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (765)
  • Economy (787)
  • Entertainment (21,664)
  • General (16,402)
  • Health (9,826)
  • Lifestyle (798)
  • News (22,149)
  • People (789)
  • Politics (797)
  • Science (16,001)
  • Sports (21,285)
  • Technology (15,768)
  • World (770)

Recent News

Plastisphere provides a unique ecological niche for microorganisms in Zostera marina seagrass meadows – Nature

Plastisphere provides a unique ecological niche for microorganisms in Zostera marina seagrass meadows – Nature

August 11, 2025
‘The best solution is to murder him in his sleep’: AI models can send subliminal messages that teach other AIs to be ‘evil,’ study claims – Live Science

AI Models Could Be Secretly Teaching Each Other to Behave ‘Evil’ Through Subliminal Messages, Study Warns

August 11, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version