* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, July 10, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

    Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

    Monumental Sports & Entertainment’s Samantha Brady on the Power of the RSN’s Direct-to-Consumer Streaming Service Monumental+ – Sports Video Group

    Samantha Brady Reveals How Monumental+ is Transforming Sports Streaming with Direct-to-Consumer Access

    Moses Singer Welcomes Entertainment and Intellectual Property Partner Frederick Bimbler – Yahoo Finance

    Moses Singer Expands Team with New Entertainment and Intellectual Property Partner Frederick Bimbler

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    SMPTE Opens Early Bird Registration for Media Technology Summit – TVTechnology

    SMPTE Launches Early Bird Registration for Exciting Media Technology Summit

    Google Fiber puts Nokia network slicing technology to the test – Fierce Network

    Google Fiber Puts Nokia’s Network Slicing Technology to the Ultimate Test

    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    Technology And Construction Names Join Top Stock Lists: Check Out Additions To IBD 50, Big Cap 20 And More – Investor’s Business Daily

    Technology and Construction Leaders Surge Into Top Stock Rankings: See the Latest Additions to IBD 50, Big Cap 20, and More

    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

    Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

    Monumental Sports & Entertainment’s Samantha Brady on the Power of the RSN’s Direct-to-Consumer Streaming Service Monumental+ – Sports Video Group

    Samantha Brady Reveals How Monumental+ is Transforming Sports Streaming with Direct-to-Consumer Access

    Moses Singer Welcomes Entertainment and Intellectual Property Partner Frederick Bimbler – Yahoo Finance

    Moses Singer Expands Team with New Entertainment and Intellectual Property Partner Frederick Bimbler

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    SMPTE Opens Early Bird Registration for Media Technology Summit – TVTechnology

    SMPTE Launches Early Bird Registration for Exciting Media Technology Summit

    Google Fiber puts Nokia network slicing technology to the test – Fierce Network

    Google Fiber Puts Nokia’s Network Slicing Technology to the Ultimate Test

    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    Technology And Construction Names Join Top Stock Lists: Check Out Additions To IBD 50, Big Cap 20 And More – Investor’s Business Daily

    Technology and Construction Leaders Surge Into Top Stock Rankings: See the Latest Additions to IBD 50, Big Cap 20, and More

    Column: Teach kupuna new technology skills – Honolulu Star-Advertiser

    Empowering Kupuna: Unlocking New Technology Skills for a Connected Future

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

New Discovery Reveals How Cells Defend Themselves During Stressful Situations

March 10, 2024
in Science
New Discovery Reveals How Cells Defend Themselves During Stressful Situations
Share on FacebookShare on Twitter

Bright Blue Cells

The study reveals that the RNA modification N4-acetylcytidine (ac4C) plays a crucial role in the formation of stress granules and the cellular response to stress, offering new insights into the molecular mechanisms involved and identifying potential targets for disease treatment.

Stress granules play a crucial role in the stress response, arising from the aggregation of non-translating mRNAs and proteins. Although significant knowledge exists about stress granules, the mechanisms behind their mRNA localization remain partially understood. Alterations to mRNA can change the characteristics of the nucleobases, influencing key processes like translation, splicing, and the positioning of specific transcripts.

The researchers show that the RNA modification N4-acetylcytidine (ac4C) on mRNA associates with transcripts enriched in stress granules and that stress granule localized transcripts with ac4C are specifically translationally regulated.

They also show that ac4C on mRNA can mediate the localization of proteins to stress granules. Their results suggest that acetylation of mRNA regulates the localization of both stress-sensitive transcripts and RNA-binding proteins to stress granules and adds to our understanding of the molecular mechanisms responsible for stress granule formation.

Stress Granule Formation and RNA Modifications

Stress granules are membrane-less assemblies of mRNA-protein complexes that arise from mRNAs stuck in translation initiation. RNA-protein complexes are important for their formation and the mechanisms promoting stress granule formation involve both conventional RNA-protein interactions and interactions that encompass intrinsically disordered regions of proteins.

Stress Granule Formation

Figure shows stress granule formation after oxidative stress in wild-type cells and cells depleted for the ac4C acetyltransferase enzyme NAT10. Credit: Pavel Kudrin

Stress granules have been extensively studied, and it is well-established that they form when translation initiation is limited a variety of roles for stress granules within the cell have been proposed. While stress granule assembly and disassembly can be regulated by various post-translational modifications the impact of RNA modifications on their formation, dispersal, and function remains largely unclear.

Impact of ac4C on Stress Granules and Cellular Stress Response

The RNA modification N4-acetylcytidine (ac4C) has recently been shown to be deposited on mRNA and regulate translation efficiency. ac4C is conserved through all kingdoms of life and is induced upon several different stresses. ac4C is less abundant than other RNA modifications on mRNA and due to difficulties in precise and quantitative mapping its function and occurrence on mRNA have remained controversial.

The researchers show in their publication that ac4C is enriched in stress granules and that acetylated transcripts are predominantly localized to stress granules in response to oxidative stress, proposing a model where acetylation of RNA can affect mRNA localization to stress granules, in part by affecting the translational release of mRNA from the ribosome, providing new insight into both the function and consequences of mRNA acetylation and mechanism of RNA localization to stress granules.

The findings will promote the understanding of how the cells react to stress and which role RNA modifications play in the process. Both stress and RNA acetylation have implications in disease and their findings could help shed light on relevant molecular pathways that could be targeted in disease.

Reference: “N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules” by Pavel Kudrin, Ankita Singh, David Meierhofer, Anna Kuśnierczyk and Ulf Andersson Vang Ørom, 27 February 2024, EMBO Reports.
DOI: 10.1038/s44319-024-00098-6

The project was led by Ulf A.V. Ørom’s lab at Aarhus University in Denmark, and the study involved collaboration with researchers from the University of Tartu, Norwegian Technical University, and the Max Planck Institute for Molecular Genetics in Berlin.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/new-discovery-reveals-how-cells-defend-themselves-during-stressful-situations/

Tags: DiscoveryRevealsscience
Previous Post

Improved Performance and Recovery – Scientists Discover New Exercise Benefits of Ginseng

Next Post

Moon’s New Scouts: NASA’s Autonomous Rovers Ready To Roll On Lunar Terrain

SMPTE Opens Early Bird Registration for Media Technology Summit – TVTechnology

SMPTE Launches Early Bird Registration for Exciting Media Technology Summit

July 10, 2025
Barstool Sports announces roster for Internet Invitational at Big Cedar Lodge – Springfield News-Leader

Barstool Sports announces roster for Internet Invitational at Big Cedar Lodge – Springfield News-Leader

July 10, 2025
Embedding information flows within ecological networks – Nature

Discovering the Hidden Dynamics of Information Flow in Ecological Networks

July 10, 2025
Mass layoffs can move forward, with devastating impacts for conservation and science – High Country News

Mass layoffs can move forward, with devastating impacts for conservation and science – High Country News

July 10, 2025
The Boar War: Michigan accused of harassing pig farmers using faulty science – Michigan Capitol Confidential

The Boar War: Michigan accused of harassing pig farmers using faulty science – Michigan Capitol Confidential

July 10, 2025
I took my daughter to meet my girlfriend — and what she found changed everything – VegOut

I took my daughter to meet my girlfriend — and what she found changed everything – VegOut

July 9, 2025
See photos of FIFA Club World Cup semifinal: PSG defeats Real Madrid at MetLife Stadium – Bergen Record

PSG Clinches Exciting Victory Over Real Madrid in FIFA Club World Cup Semifinal – Stunning Photos Inside!

July 9, 2025
The Economic Consequences of the Big Odious Bill – The New Yorker

The Economic Consequences of the Big Odious Bill – The New Yorker

July 9, 2025
Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

July 9, 2025
Why 1.5 Million New Yorkers Could Lose Health Insurance Under Trump Bill – The New York Times

How 1.5 Million New Yorkers Could Face Losing Health Insurance Under Trump’s Proposed Bill

July 9, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (713)
  • Economy (737)
  • Entertainment (21,626)
  • General (15,806)
  • Health (9,774)
  • Lifestyle (743)
  • News (22,149)
  • People (738)
  • Politics (746)
  • Science (15,954)
  • Sports (21,236)
  • Technology (15,722)
  • World (719)

Recent News

SMPTE Opens Early Bird Registration for Media Technology Summit – TVTechnology

SMPTE Launches Early Bird Registration for Exciting Media Technology Summit

July 10, 2025
Barstool Sports announces roster for Internet Invitational at Big Cedar Lodge – Springfield News-Leader

Barstool Sports announces roster for Internet Invitational at Big Cedar Lodge – Springfield News-Leader

July 10, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version