* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, July 24, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

    AP Entertainment SummaryBrief at 1:51 p.m. EDT – Channel 3000

    Entertainment Highlights: Key Updates You Can’t Miss

    ‘Devil Wears Prada 2’ casts Anne Hathaway’s love interest replacing Adrian Grenier’s Nate – Entertainment Weekly

    Devil Wears Prada 2′ Casts New Love Interest for Anne Hathaway, Replacing Adrian Grenier’s Nate

    12 ‘Late Show’ Moments Proving Stephen Colbert Can’t Be Replaced – The Mountaineer

    12 Unforgettable ‘Late Show’ Moments That Prove Stephen Colbert Is Truly One of a Kind

    Canes owner Tom Dundon’s real estate firm eyes entertainment complex near RDU – The Business Journals

    Canes Owner Tom Dundon’s Real Estate Firm Unveils Plans for Thrilling New Entertainment Complex Near RDU

    Inspired Entertainment, Inc.’s (NASDAQ:INSE) Price Is Right But Growth Is Lacking After Shares Rocket 29% – simplywall.st

    Inspired Entertainment Soars 29% but Growth Momentum Falls Short

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Sustainserv and Palau Announce Technology Partnership to Leverage Innovative AI Platform to Advance Sustainability Reporting – Business Wire

    Sustainserv and Palau Team Up to Transform Sustainability Reporting with Breakthrough AI Technology

    Morgan Adamski Joins PwC in Newly Created Cyber, Data & Technology Risk Division – HSToday

    Morgan Adamski Leads the Charge in PwC’s Cutting-Edge Cyber, Data & Technology Risk Division

    Transformative technology, support for food entrepreneurs spotlighted – University of Hawaii System

    How Cutting-Edge Technology and Strong Support Are Revolutionizing Food Entrepreneurs’ Success

    Cold Weather Alloy Opens New Possibilities for Space Technology – Universe Today

    Revolutionary Cold Weather Alloy Unlocks New Frontiers in Space Technology

    Defence Holdings PLC Transitions from Esports to Pioneering Defence Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Black Box Players presents ‘The Three Musketeers’ – CBS 19 News

    Experience the Adventure: Black Box Players Bring ‘The Three Musketeers’ to Life!

    AP Entertainment SummaryBrief at 1:51 p.m. EDT – Channel 3000

    Entertainment Highlights: Key Updates You Can’t Miss

    ‘Devil Wears Prada 2’ casts Anne Hathaway’s love interest replacing Adrian Grenier’s Nate – Entertainment Weekly

    Devil Wears Prada 2′ Casts New Love Interest for Anne Hathaway, Replacing Adrian Grenier’s Nate

    12 ‘Late Show’ Moments Proving Stephen Colbert Can’t Be Replaced – The Mountaineer

    12 Unforgettable ‘Late Show’ Moments That Prove Stephen Colbert Is Truly One of a Kind

    Canes owner Tom Dundon’s real estate firm eyes entertainment complex near RDU – The Business Journals

    Canes Owner Tom Dundon’s Real Estate Firm Unveils Plans for Thrilling New Entertainment Complex Near RDU

    Inspired Entertainment, Inc.’s (NASDAQ:INSE) Price Is Right But Growth Is Lacking After Shares Rocket 29% – simplywall.st

    Inspired Entertainment Soars 29% but Growth Momentum Falls Short

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Behind the Screens: The Impact of Technology on Real Estate – TRREB

    Behind the Screens: How Technology is Transforming the Future of Real Estate

    Sustainserv and Palau Announce Technology Partnership to Leverage Innovative AI Platform to Advance Sustainability Reporting – Business Wire

    Sustainserv and Palau Team Up to Transform Sustainability Reporting with Breakthrough AI Technology

    Morgan Adamski Joins PwC in Newly Created Cyber, Data & Technology Risk Division – HSToday

    Morgan Adamski Leads the Charge in PwC’s Cutting-Edge Cyber, Data & Technology Risk Division

    Transformative technology, support for food entrepreneurs spotlighted – University of Hawaii System

    How Cutting-Edge Technology and Strong Support Are Revolutionizing Food Entrepreneurs’ Success

    Cold Weather Alloy Opens New Possibilities for Space Technology – Universe Today

    Revolutionary Cold Weather Alloy Unlocks New Frontiers in Space Technology

    Defence Holdings PLC Transitions from Esports to Pioneering Defence Technology

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

New drug delivery system shows promise in treatment of life-threatening pregnancy condition

July 25, 2023
in Science
New drug delivery system shows promise in treatment of life-threatening pregnancy condition
Share on FacebookShare on Twitter

Researchers in the Oregon State University College of Pharmacy have developed a drug delivery system that shows promise for greatly enhancing the efficacy of the medicine given to women with the life-threatening condition of ectopic pregnancy, which occurs when a fertilized egg implants somewhere other than the lining of the uterus.

Olena Taratula of the OSU College of Pharmacy, and Maureen Baldwin and Leslie Myatt of Oregon Health & Science University led a team that used a mouse model to show that the drug, methotrexate, ends pregnancy at a comparatively low dose when administered via nanoparticles known as polymersomes.

Findings were published in the journal Small.

Ectopic pregnancies are non-viable and the leading cause of maternal death in the first trimester. Methotrexate, commonly abbreviated to MTX, fails at greater than 10% rate because it doesn’t always accumulate properly at the implantation site — a problem the polymersomes address.

MTX ends ectopic pregnancy by causing embryonic cells to stop dividing, and even when it works, it comes with a collection of potential negatives for the patient: nausea, vomiting, diarrhea, elevated liver enzymes, kidney damage and lung disease. A lower dose, the scientists say, would be a step in the right direction for reducing side effects as well as increasing efficacy.

Two percent of all pregnancies in the United States, and between 1% and 2% worldwide, are ectopic, the authors note. In the U.S. alone that translates to approximately 100,000 ectopic pregnancies annually.

About 98% of ectopic implantations happen in the fallopian tubes, putting women at risk of hemorrhage and death.

“Developing drugs able to target specific locations in the body remains one of biomedicine’s greatest challenges,” Taratula said. “Most of the drugs prescribed today, including MTX, have no means of working only on specific tissues or cells. When drugs affect healthy cells, it can drastically reduce a patient’s quality of life — think of the severe effects of chemotherapy like hair, loss of the lining of the gut, ulcer formation, nausea, etc.”

Taratula, Baldwin and other researchers at OHSU and the Oregon State College of Pharmacy sought to reduce MTX’s shortcomings by exploring whether packaging it in a special type of nanoparticle, polymersomes, would enable the drug to target only embryonic cells.

Polymersomes are hollow spheres that are synthetic versions of liposomes, lipid-based sacs found in all living cells. The scientists developed a polymersome that would respond to the high concentrations of a substance known as glutathione in placental cells; loading MTX into polymersomes keeps it from acting until the glutathione triggers its release.

“A dose of MTX delivered by polymersomes induced the end of pregnancy in mice, whereas the same dose of MTX by itself didn’t,” Taratula said. “To achieve the same therapeutic efficacy with MTX alone, we had to increase the dosage sixfold. Also very promising is that, after having pregnancies ended by MTX-loaded polymersomes, mice successfully conceived and gave birth to healthy offspring.”

Collaborators on the study included Babak Mamnoon, Abraham Moses, Constanze Raitmayr and Oleh Taratula of the OSU College of Pharmacy and Terry Morgan of OHSU. The College of Pharmacy, the OHSU School of Medicine and the National Institutes of Health provided funding.

Taratula is also continuing her research into using other types of nanoparticles to both diagnose and end ectopic pregnancies. A year ago she led a collaboration that developed a light-sensitive nanoparticle for those purposes, and she recently received a $3 million grant from the National Institutes of Health to develop a magnetic nanoparticle platform.

The magnetic nanoparticles would potentially be even more effective than the light-sensitive ones, she said, because a magnetic field has deeper tissue penetration than light.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Science Daily – https://www.sciencedaily.com/releases/2023/07/230724200735.htm

Tags: Deliverysciencesystem
Previous Post

Whitehorse on Unlikely Inspirations, Looping Headaches, and Writing in Lockdown

Next Post

Scientists discover new isopod species in the Florida Keys

Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity – Nature

Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity – Nature

July 24, 2025
Three Recent Texas Science Graduates Receive Fulbright U.S. Student Awards – College of Natural Sciences

Three Texas Science Graduates Honored with Prestigious Fulbright U.S. Student Awards

July 24, 2025
An Extra Sense May Connect Gut Bacteria With Our Brain – ScienceAlert

An Extra Sense May Connect Gut Bacteria With Our Brain – ScienceAlert

July 24, 2025
Nutrition and lifestyle hold the key to overcoming obesity risk – The Hans India

Unlock the Secret to Beating Obesity: How Nutrition and Lifestyle Transform Your Health

July 24, 2025
He ‘found his place in the world’ through football. Then came 15 years of suffering – The New York Times

From Football Dreams to 15 Years of Unyielding Struggle: One Man’s Journey to Finding His Place in the World

July 24, 2025
How Nuclear Fusion Could Revive This State’s Startup Economy – Inc.com

How Nuclear Fusion Could Spark a Revival in This State’s Startup Scene

July 24, 2025
Hollywood’s writers won the strike but lost the work – Spectrum News

Hollywood Writers Win Strike Victory but Confront New Challenges Ahead

July 24, 2025
Health For All reminds Brazos Valley of healthy habits, resources during summer months – KBTX News 3

Stay Healthy This Summer: Must-Know Tips and Resources for Brazos Valley Residents

July 24, 2025
Democrat Roy Cooper expected to run for Senate from North Carolina, sources tell CNN – CNN

Democrat Roy Cooper Launches Thrilling Campaign for North Carolina Senate Seat

July 24, 2025
Behind the Screens: The Impact of Technology on Real Estate – TRREB

Behind the Screens: How Technology is Transforming the Future of Real Estate

July 24, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (737)
  • Economy (760)
  • Entertainment (21,642)
  • General (16,078)
  • Health (9,798)
  • Lifestyle (768)
  • News (22,149)
  • People (762)
  • Politics (769)
  • Science (15,976)
  • Sports (21,257)
  • Technology (15,742)
  • World (743)

Recent News

Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity – Nature

Threat reduction must be coupled with targeted recovery programmes to conserve global bird diversity – Nature

July 24, 2025
Three Recent Texas Science Graduates Receive Fulbright U.S. Student Awards – College of Natural Sciences

Three Texas Science Graduates Honored with Prestigious Fulbright U.S. Student Awards

July 24, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version