* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, August 22, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    How to watch ‘F1: The Movie’ on Prime Video – About Amazon

    Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    What Are Our Predictions for Taylor Swift’s ‘Life of a Showgirl’ Based on What She’s Told Us So Far? – yahoo.com

    Uncover the Hidden Surprises in Taylor Swift’s ‘Life of a Showgirl’ – Can You Decode Her Clues?

    Bama Dining Serving Up New Food, Entertainment – UA News Center

    Bama Dining Launches Thrilling New Food and Entertainment Experiences

    The latest on Williams-Brice Stadium renovations, entertainment district – On3

    Discover the Thrilling New Upgrades Coming to Williams-Brice Stadium and Its Vibrant Entertainment District!

    1000+ Entertainment Leaders Release Open Letter Criticizing TIFF’s Handling of Film – Creative Community for Peace

    1000+ Entertainment Leaders Release Open Letter Criticizing TIFF’s Handling of Film – Creative Community for Peace

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

    Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

    Teaching older adults how to use technology – WWNY

    Empowering Older Adults to Master Technology with Confidence

    Denver man receives pacemaker using new technology – CBS News

    Denver Man’s Life Transformed by Revolutionary Pacemaker Technology

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    YSU to celebrate launch of new radiology technology program – WKBN.com

    YSU Launches Exciting New Radiology Technology Program Celebration

    Thaddeus Stevens College of Technology kicks off return to school for Lancaster County colleges [photos] – LancasterOnline

    Thaddeus Stevens College of Technology Kicks Off an Exciting New School Year for Lancaster County Colleges [Photos]

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    How to watch ‘F1: The Movie’ on Prime Video – About Amazon

    Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    What Are Our Predictions for Taylor Swift’s ‘Life of a Showgirl’ Based on What She’s Told Us So Far? – yahoo.com

    Uncover the Hidden Surprises in Taylor Swift’s ‘Life of a Showgirl’ – Can You Decode Her Clues?

    Bama Dining Serving Up New Food, Entertainment – UA News Center

    Bama Dining Launches Thrilling New Food and Entertainment Experiences

    The latest on Williams-Brice Stadium renovations, entertainment district – On3

    Discover the Thrilling New Upgrades Coming to Williams-Brice Stadium and Its Vibrant Entertainment District!

    1000+ Entertainment Leaders Release Open Letter Criticizing TIFF’s Handling of Film – Creative Community for Peace

    1000+ Entertainment Leaders Release Open Letter Criticizing TIFF’s Handling of Film – Creative Community for Peace

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

    Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

    Teaching older adults how to use technology – WWNY

    Empowering Older Adults to Master Technology with Confidence

    Denver man receives pacemaker using new technology – CBS News

    Denver Man’s Life Transformed by Revolutionary Pacemaker Technology

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    Morgan County Rescue Squad is using new technology to recover people missing in the water faster – WAFF

    YSU to celebrate launch of new radiology technology program – WKBN.com

    YSU Launches Exciting New Radiology Technology Program Celebration

    Thaddeus Stevens College of Technology kicks off return to school for Lancaster County colleges [photos] – LancasterOnline

    Thaddeus Stevens College of Technology Kicks Off an Exciting New School Year for Lancaster County Colleges [Photos]

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

New stapling method solves floppy peptide problem

July 17, 2023
in Science
New stapling method solves floppy peptide problem
Share on FacebookShare on Twitter

New stapling method solves floppy peptide problem

Graphical abstract. Credit: Journal of the American Chemical Society (2023). DOI: 10.1021/jacs.3c02743

In a cutting-edge discovery, published in the Journal of the American Chemical Society, Florey scientists have solved a long-standing problem: the need for an affordable, simple way to make peptide-based drugs that hold their necessary shape.

Professor Akhter Hossain, Head of the Insulin Peptides Group at The Florey, said peptides, the smaller relatives of proteins, are easy to make in a laboratory, have therapeutic potential and are considered safe. However, without the proper structure, the peptides become floppy and inactive.

“Peptides form unique structures that fit like jigsaw pieces into receptors in the brain or elsewhere in the body. They modulate a diverse range of essential bodily functions.”

Professor Hossain said our bodies naturally use complicated means of introducing structure into peptides to make them work, which is challenging to replicate in the drug development.

“Peptide stapling has been highly successful in overcoming this problem but the current methods are costly and involve complex chemistry and purification,” he said.

The paper’s lead author and Head of The Florey’s Neurotherapeutics Theme, Professor Ross Bathgate, said by simplifying peptide stapling, the team had turned a multi-step, week-long process into a shorter, single-step one.

“Our new approach is flexible, easy to implement, and will make it easier for researchers and pharmaceutical companies to develop peptide-based drugs. Now we can easily make peptides with the correct structure to bind to their target receptors. Our ultimate goal is for this technology to be used to treat a range of disorders,” Professor Bathgate said.

“In our laboratories at The Florey we’ve used this technology successfully in the earliest stage of drug discovery, and believe it will likely be applicable to a range of potential therapeutic targets for peptide-based drugs,” Professor Hossain said.

More information:
Ross A. D. Bathgate et al, Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics, Journal of the American Chemical Society (2023). DOI: 10.1021/jacs.3c02743

Provided by
Florey Institute of Neuroscience and Mental Health

Citation:
New stapling method solves floppy peptide problem (2023, July 17)
retrieved 17 July 2023
from https://phys.org/news/2023-07-stapling-method-floppy-peptide-problem.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Phys.org – https://phys.org/news/2023-07-stapling-method-floppy-peptide-problem.html

Tags: methodsciencestapling
Previous Post

Roborock Q Revo Review: An Autonomous Champion

Next Post

Virgin Galatic’s next spaceflight will include sweepstakes winners

‘Urgent action’ needed to protect workers from heat stress in warming world, UN says – Reuters

Urgent Action Needed to Shield Workers from Rising Heat Risks in a Warming World

August 22, 2025
The United States’ Biggest Vulnerability in the Trade War: Its Knowledge Economy – World Politics Review

The United States’ Greatest Weakness in the Trade War: Its Knowledge Economy

August 22, 2025
How to watch ‘F1: The Movie’ on Prime Video – About Amazon

Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

August 22, 2025
Willis Knighton Health in Louisiana joins Mayo Clinic Care Network – Mayo Clinic News Network

Willis Knighton Health Teams Up with Mayo Clinic Care Network to Elevate Patient Care in Louisiana

August 22, 2025
Focus on the Family James Dobson’s harsh Christianity changed GOP politics – MSNBC News

Focus on the Family James Dobson’s harsh Christianity changed GOP politics – MSNBC News

August 22, 2025

Sliteye Shark Discovered in Remote Indian Ocean – environment coastal & offshore

August 22, 2025
Summary of the 2025 GEDI Science Team Meeting – NASA Science (.gov)

Summary of the 2025 GEDI Science Team Meeting – NASA Science (.gov)

August 22, 2025
Hamilton to Launch Collegiate Science and Technology Entry Program – Hamilton College

Hamilton Unveils Exciting New Science and Technology Entry Program for College Students

August 22, 2025
Dating App Burnout Is Real But It Doesn’t Have to Be Your Reality, Love Bites with Lifestyle Coach Francesca Luca – WATD 95.9 FM

Beat Dating App Burnout: Expert Tips to Keep Your Love Life Thrilling with Lifestyle Coach Francesca Luca

August 22, 2025
Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

August 22, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (784)
  • Economy (805)
  • Entertainment (21,684)
  • General (16,613)
  • Health (9,845)
  • Lifestyle (817)
  • News (22,149)
  • People (806)
  • Politics (814)
  • Science (16,017)
  • Sports (21,303)
  • Technology (15,785)
  • World (786)

Recent News

‘Urgent action’ needed to protect workers from heat stress in warming world, UN says – Reuters

Urgent Action Needed to Shield Workers from Rising Heat Risks in a Warming World

August 22, 2025
The United States’ Biggest Vulnerability in the Trade War: Its Knowledge Economy – World Politics Review

The United States’ Greatest Weakness in the Trade War: Its Knowledge Economy

August 22, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version