* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, May 31, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Rachel Guttman Launches Entertainment Law Firm Gutt Law, PLLC [Exclusive] – MusicRow.com

    Rachel Guttman Unveils Exciting New Entertainment Law Firm: Gutt Law, PLLC!

    HYBE Cashes In: Offloads Final Stake in K-Pop Rival SM Entertainment for $177 Million!

    Allied Gaming & Entertainment Receives Expected Nasdaq Notice Regarding Delayed Quarterly Report – Business Wire

    Allied Gaming & Entertainment Faces Nasdaq Notice Over Delayed Quarterly Report

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Aziz Ansari made Keanu Reeves Indian food so he wouldn’t feel ‘freaked out’ directing him in Good Fortune (exclusive) – Entertainment Weekly

    Aziz Ansari Whips Up Indian Cuisine for Keanu Reeves to Ease Directing Jitters in Good Fortune

    Cassie Ventura welcomes third child – crossroadstoday.com

    Cassie Ventura Joyfully Welcomes Her Third Child!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Stop the Machines: The Rise of Anti-Technology Extremism – International Centre for Counter-Terrorism – ICCT

    Unplugged: The Surge of Anti-Technology Extremism

    Finland to head EU’s quantum defense technology project – Latest news from Azerbaijan

    Finland Takes the Lead in Pioneering EU’s Quantum Defense Technology Initiative!

    i3D Robotics Unveils Breakthrough Glass Defect Detection Technology – USGlass Magazine

    Revolutionary Glass Defect Detection Technology Unveiled by i3D Robotics!

    4Liberty Announces Collaboration with Itron to Drive Innovation in Utility Technology Adoption and Optimization – FinancialContent

    4Liberty Partners with Itron to Revolutionize Utility Technology and Boost Innovation

    Q1 2025 Quantum Technology Investment: What’s Driving the Surge in Quantum Investment? – The Quantum Insider

    Unleashing the Future: Exploring the Surge in Quantum Technology Investments for Q1 2025

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Rachel Guttman Launches Entertainment Law Firm Gutt Law, PLLC [Exclusive] – MusicRow.com

    Rachel Guttman Unveils Exciting New Entertainment Law Firm: Gutt Law, PLLC!

    HYBE Cashes In: Offloads Final Stake in K-Pop Rival SM Entertainment for $177 Million!

    Allied Gaming & Entertainment Receives Expected Nasdaq Notice Regarding Delayed Quarterly Report – Business Wire

    Allied Gaming & Entertainment Faces Nasdaq Notice Over Delayed Quarterly Report

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Weekly Entertainment Report May 29-June 1: Where to find lively arts, music, and shows – Manchester Ink Link

    Aziz Ansari made Keanu Reeves Indian food so he wouldn’t feel ‘freaked out’ directing him in Good Fortune (exclusive) – Entertainment Weekly

    Aziz Ansari Whips Up Indian Cuisine for Keanu Reeves to Ease Directing Jitters in Good Fortune

    Cassie Ventura welcomes third child – crossroadstoday.com

    Cassie Ventura Joyfully Welcomes Her Third Child!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Stop the Machines: The Rise of Anti-Technology Extremism – International Centre for Counter-Terrorism – ICCT

    Unplugged: The Surge of Anti-Technology Extremism

    Finland to head EU’s quantum defense technology project – Latest news from Azerbaijan

    Finland Takes the Lead in Pioneering EU’s Quantum Defense Technology Initiative!

    i3D Robotics Unveils Breakthrough Glass Defect Detection Technology – USGlass Magazine

    Revolutionary Glass Defect Detection Technology Unveiled by i3D Robotics!

    4Liberty Announces Collaboration with Itron to Drive Innovation in Utility Technology Adoption and Optimization – FinancialContent

    4Liberty Partners with Itron to Revolutionize Utility Technology and Boost Innovation

    Q1 2025 Quantum Technology Investment: What’s Driving the Surge in Quantum Investment? – The Quantum Insider

    Unleashing the Future: Exploring the Surge in Quantum Technology Investments for Q1 2025

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    MIT Team Releases Tempting Report on Electric Aircraft Technology – AVweb

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Photodynamic action weakens resistance to antibiotics in bacteria that attack airways

December 18, 2023
in Science
Photodynamic action weakens resistance to antibiotics in bacteria that attack airways
Share on FacebookShare on Twitter

Photodynamic action weakens resistance to antibiotics in bacteria that attack airways

The research group analyzed patient samples containing Staphylococcus aureus, a bacterium that causes a range of diseases from skin infections to pneumonia. Credit: Janice Haney Carr/CDC PHIL

The development of antibiotics to combat multidrug-resistant bacteria, especially those that infect the airways, has been increasingly tricky, and some scientists have opted to try to weaken the bacteria so that the available therapeutic substances are made more effective.

This approach is promising, as shown by an article published in the journal Proceedings of the National Academy of Sciences (PNAS), which concludes that photodynamic inactivation (PDI) showed a novel capacity to modify bacterial sensitivity to antibiotics according to dosage, reducing the resistance and persistence of both standard and clinical strains.

The lead author is Vanderlei Salvador Bagnato, a physicist and materials engineer at the University of São Paulo’s São Carlos Institute of Physics (IFSC-USP) in Brazil.

The study focused on Staphylococcus aureus, a bacterium that causes a range of diseases from skin infections to pneumonia, investigating the effects of photodynamic action on resistant bacteria collected from patients and bacterial cells with laboratory-induced resistance. The results showed that five cycles of PDI were sufficient to break their resistance.

In PDI, a dye called a photosensitizer is energized by absorbing visible light to form reactive oxygen species that can oxidize and destroy microorganisms or weaken their antibiotic resistance.

The researchers used 10 μM curcumin as the photosensitizer and worked with three antibiotics—amoxicillin, erythromycin, and gentamicin. After the five cycles of PDI, they found that S. aureus was most susceptible to gentamicin, although the other two antibiotics also proved effective against the bacteria after PDI.

“We discovered that PDI doesn’t always destroy the bacteria, but it does destroy part of the mechanisms they use to become drug-resistant. This led to the idea of trying an oxidative shock to make them susceptible to antibiotics,” Bagnato told Agência FAPESP. Bagnato is principal investigator for the Optics and Photonics Research Center (CePOF).

The first author of the article is Jennifer Soares, a researcher at IFSC-USP and CePOF. As a former Ph.D. candidate, she studied under Bagnato and co-author Kate Cristina Blanco, also a professor at IFSC-USP and a member of CePOF.

Multidrug-resistant bacteria

The World Health Organization (WHO) has prioritized antimicrobial resistance (AMR) as one of the top 10 global public health threats facing humanity. AMR is a process that occurs as bacteria, viruses, fungi, and parasites change over time and no longer respond to antibiotics and antivirals, for example.

The WHO estimates that some 1.2 million deaths are caused directly by AMR every year, and almost 5 million are indirectly associated with it. AMR could cost the global economy USD 100 trillion by 2050 if no action is taken.

According to a report issued last year by the WHO, out of every 100 patients in acute-care hospitals, seven patients in high-income countries and 15 patients in low- and middle-income countries will acquire at least one health care-associated infection (HAI) during their hospital stay. On average, 1 in every 10 affected patients will die from their HAI. “Deaths are increased two to threefold when infections are resistant to antimicrobials,” the report adds.

According to the PNAS article, the chances of approval of new antibiotics by the US Food and Drug Administration (FDA) for clinical trials in humans is 6 out of 10, and the probability that those approved will be a new antibiotic class is only 25%, which “implies a low probability of solving the bacterial resistance problem since most new antimicrobials tend to derive from existing classes.”

Bagnato’s research has focused for several years on drug-resistant pneumonia, one of the drug-resistant infections that most frequently cause deaths in intensive care units. “We’re about to publish an article describing a technique applied directly in the lungs. The patient inhales an inductive molecule, and we do extracorporeal infrared illumination to weaken the microorganism’s resistance as part of a strategy to combat pneumonia, for example,” he said.

More information:
Jennifer M. Soares et al, Recovering the susceptibility of antibiotic-resistant bacteria using photooxidative damage, Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2311667120

Citation:
Photodynamic action weakens resistance to antibiotics in bacteria that attack airways (2023, December 18)
retrieved 18 December 2023
from https://phys.org/news/2023-12-photodynamic-action-weakens-resistance-antibiotics.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Phys.org – https://phys.org/news/2023-12-photodynamic-action-weakens-resistance-antibiotics.html

Tags: actionPhotodynamicscience
Previous Post

Little bacterium may make big impact on rare-earth processing

Next Post

Exoplanets’ climate: It takes nothing to switch from habitable to hell, say researchers

Bar-B-Cast on Red Sox’s struggles and ugly season: ‘Alex Cora is going nowhere at least this season’ – Yahoo Sports

Bar-B-Cast on Red Sox’s struggles and ugly season: ‘Alex Cora is going nowhere at least this season’ – Yahoo Sports

May 31, 2025

Revolutionary Approach to Assessing the Ecological Impact of Offshore Activities

May 31, 2025
OpenAI’s ‘smartest’ AI model was explicitly told to shut down — and it refused – Live Science

OpenAI’s ‘Smartest’ AI Model Defies Shutdown Command!

May 31, 2025
Alarmed by Trump Cuts, Scientists Are Talking Science. For 100 Hours. – The New York Times

Scientists Unite for 100 Hours of Dialogue in Response to Trump’s Budget Cuts

May 31, 2025
The big ‘Cheese’: Apple TV+ series delivers a surrealist family comedy – Albuquerque Journal

The big ‘Cheese’: Apple TV+ series delivers a surrealist family comedy – Albuquerque Journal

May 31, 2025
International Research Team Builds World’s Most Efficient Organic Solar Cell – SciTechDaily

Revolutionary Breakthrough: Scientists Create the Most Efficient Organic Solar Cell Yet!

May 31, 2025
JPMorgan’s Dimon discusses dangers from ‘tectonic shifts’ in geopolitics, the global economy (JPM:NYSE) – Seeking Alpha

Dimon Warns of Geopolitical ‘Tectonic Shifts’ Impacting the Global Economy

May 31, 2025
Khruangbin takes Boise on a hypnotic journey – Idaho Press

Khruangbin Transports Boise into a Mesmerizing Musical Odyssey

May 31, 2025
VSee Health, Inc. Receives Nasdaq Notice on Delayed Form 10-Q Filing – Business Wire

VSee Health Faces Nasdaq Notice Over Delayed 10-Q Filing: What It Means for the Future

May 31, 2025
A 30 Year Dungeons and Dragons Game Gets Upended By Politics – StoryCorps

How Politics Turned a 30-Year Dungeons and Dragons Campaign Upside Down

May 31, 2025

Categories

Archives

May 2025
MTWTFSS
 1234
567891011
12131415161718
19202122232425
262728293031 
« Apr    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (653)
  • Economy (667)
  • Entertainment (21,573)
  • General (15,251)
  • Health (9,709)
  • Lifestyle (669)
  • News (22,149)
  • People (669)
  • Politics (675)
  • Science (15,889)
  • Sports (21,172)
  • Technology (15,654)
  • World (655)

Recent News

Bar-B-Cast on Red Sox’s struggles and ugly season: ‘Alex Cora is going nowhere at least this season’ – Yahoo Sports

Bar-B-Cast on Red Sox’s struggles and ugly season: ‘Alex Cora is going nowhere at least this season’ – Yahoo Sports

May 31, 2025

Revolutionary Approach to Assessing the Ecological Impact of Offshore Activities

May 31, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version