Scalable genomic data exchange and analytics with sBeacon

Anuradha Wickramarachchi 
ORCID: orcid.org/0000-0003-4160-59651 na1, Brendan Hosking1 na1, Yatish Jain 
ORCID: orcid.org/0000-0002-0556-65861,2 na1, John Grimes3, Mitchell J. O’Brien 
ORCID: orcid.org/0000-0003-0662-91011, Tracey Wright3, Mark A. Burgess4, Victor San Kho Lin 
ORCID: orcid.org/0000-0002-3940-47295, Florian Reisinger5, Oliver Hofmann5, Michael Lawley 
ORCID: orcid.org/0000-0001-9508-47693, Laurence O. W. Wilson1,2, Natalie A. Twine1,2 & …Denis C. Bauer 
ORCID: orcid.org/0000-0001-8033-98102,6,7 

Nature Biotechnology

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Fig. 1: sBeacon application cases and comparison with existing implementations.

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Acknowledgements

The authors thank CSIRO for financial support and the Australian Genomics Health Alliances for their input to this work.

Author information

Author notes

These authors contributed equally: Anuradha Wickramarachchi, Brendan Hosking, Yatish Jain.

Authors and Affiliations

Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Westmead, New South Wales, Australia

Anuradha Wickramarachchi, Brendan Hosking, Yatish Jain, Mitchell J. O’Brien, Laurence O. W. Wilson & Natalie A. Twine

Applied BioSciences, Faculty of Science and Engineering, Macquarie University, Macquarie Park, New South Wales, Australia

Yatish Jain, Laurence O. W. Wilson, Natalie A. Twine & Denis C. Bauer

Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Herston, Queensland, Australia

John Grimes, Tracey Wright & Michael Lawley

Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Canberra, Australian Capital Territory, Australia

Mark A. Burgess

Centre for Cancer Research, University of Melbourne, Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia

Victor San Kho Lin, Florian Reisinger & Oliver Hofmann

Department of Biomedical Sciences, Macquarie University, Macquarie Park, New South Wales, Australia

Denis C. Bauer

Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Adelaide, South Australia, Australia

Denis C. Bauer

Contributions

A.W., B.H. and T.W. implemented sBeacon and conducted experiments with Y.J., M.J.O’B. and M.A.B.; J.G. and M.L. guided Ontoserver integration; V.S.K.L., F.R., O.H., L.O.W.W., N.A.T. and D.C.B. conceived and supervised the study. All authors contributed to the document.

Corresponding author

Correspondence to
Denis C. Bauer.

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Competing interests

The authors declare no competing interests.

Peer review

Peer review information

Nature Biotechnology thanks Jordi Rambla and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Wickramarachchi, A., Hosking, B., Jain, Y. et al. Scalable genomic data exchange and analytics with sBeacon.
Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-01972-9

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Published: 14 September 2023

DOI: https://doi.org/10.1038/s41587-023-01972-9

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