* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Friday, August 1, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

    Micro wrestling coming to NE Ohio – Cleveland.com

    Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

    Micro wrestling coming to NE Ohio – Cleveland.com

    Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Scientists Discover That a Mysterious Type of Fat Reprograms the Memory of Innate Immune Cells

January 11, 2024
in Science
Scientists Discover That a Mysterious Type of Fat Reprograms the Memory of Innate Immune Cells
Share on FacebookShare on Twitter

Fat Cells Concept

Researchers have uncovered a significant relationship between sphingolipids and the memory of innate immune cells. This discovery opens up new treatment possibilities for diseases where the immune system is overly active, such as autoimmune disorders and cardiovascular diseases. The team found that manipulating sphingolipids in immune cells can either inhibit or stimulate their memory, with the protein acid ceramidase playing a pivotal role in this process. This breakthrough suggests new therapeutic approaches to balance the immune response. Credit: SciTechDaily.com

Researchers at Radboud University Medical Center have discovered an intriguing link between sphingolipids, a mysterious type of fat named after the ‘Sphinx’, and the memory of cells in the innate immune system. This finding opens up exciting possibilities for creating novel therapies for a range of diseases, such as autoimmune conditions, cancer, cardiovascular diseases, and in the field of organ transplantation. The details of this breakthrough are detailed in a publication in Cell Reports.

The innate immune system, crucial for defense against infections, plays a key role in various diseases involving the immune system. The researchers have demonstrated that sphingolipids can reprogram the memory of innate immune cells, offering new possibilities for treatment.

The memory of innate immune cells, also known as trained immunity, enables these cells to respond stronger and faster during recurrent infections, a vital capability. However, in diseases where the innate immune system is overreactive, such as autoimmune diseases, cardiovascular diseases, and organ transplantations, this can have adverse effects. Understanding the molecular mechanisms behind this ‘memory’ is essential for developing new treatments for these diseases.

Manipulating Innate Immune Memory with Fats

An international research team led by Raphaël Duivenvoorden, together with researcher Nils Rother, discovered that sphingolipids play a crucial role in regulating trained immunity. Using nanoparticles containing sphingolipids, they demonstrated that these fats determine the induction of trained immunity.

Some sphingolipids inhibited memory, while others stimulated it. What makes this discovery even more remarkable is that inhibiting the protein acid ceramidase, which regulates sphingolipid metabolism in cells, had the most potent effect on suppressing trained immunity. Rother states: “By inhibiting acid ceramidase, we can completely suppress the activation of trained immunity.”

A New Target for Treatment

These findings provide new insights into how trained immunity is regulated and offer a new target for the development of treatments for diseases involving trained immunity. Manipulating the sphingolipid balance in innate immune cells opens new possibilities for developing therapies that can restore the balance between effective defense and an overactive response.

Reference: “Acid ceramidase regulates innate immune memory” by Nils Rother, Cansu Yanginlar, Geoffrey Prévot, Inge Jonkman, Maaike Jacobs, Mandy M.T. van Leent, Julia van Heck, Vasiliki Matzaraki, Anthony Azzun, Judit Morla-Folch, Anna Ranzenigo, William Wang, Roy van der Meel, Zahi A. Fayad, Niels P. Riksen, Luuk B. Hilbrands, Rik G.H. Lindeboom, Joost H.A. Martens, Michiel Vermeulen, Leo A.B. Joosten, Mihai G. Netea, Willem J.M. Mulder, Johan van der Vlag, Abraham J.P. Teunissen and Raphaël Duivenvoorden, 22 November 2023, Cell Reports.
DOI: 10.1016/j.celrep.2023.113458

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/scientists-discover-that-a-mysterious-type-of-fat-reprograms-the-memory-of-innate-immune-cells/

Tags: discoverscienceScientists
Previous Post

Life Beyond Our Solar System: NASA Finds Icy Exoplanets May Have Habitable Oceans and Geysers

Next Post

International Action Is Needed – Africa Is Suffering a Dangerous Air Pollution Crisis

‘Enough is enough,’ say Global South bishops in climate letter – U.S. Catholic

Enough is Enough’: Global South Bishops Deliver Urgent Plea for Bold Climate Action

August 1, 2025
Science Central names new executive director – 21Alive

Science Central Welcomes New Executive Director to Lead Exciting Future

August 1, 2025
Citizen Scientists Are Accelerating Ecology Research, Study Suggests – The New York Times

Citizen Scientists Are Accelerating Ecology Research, Study Suggests – The New York Times

August 1, 2025
I tried Beyoncé’s brutal pre-Coachella vegan diet—and here’s the unfiltered truth – VegOut

I tried Beyoncé’s brutal pre-Coachella vegan diet—and here’s the unfiltered truth – VegOut

August 1, 2025
U17 World Wrestling Championships: Day 3 Live Results – United World Wrestling

U17 World Wrestling Championships Day 3: Live Action and Results

August 1, 2025
New GDP data leads Trump to change his mind about blaming Biden for the economy – MSNBC News

New GDP Figures Force Trump to Rethink Blaming Biden for Economic Woes

August 1, 2025
‘Soft summer’ in Las Vegas, says one of Strip’s largest operators – Las Vegas Review-Journal

Las Vegas Braces for a “Soft Summer,” Warns Leading Strip Operator

August 1, 2025
‘Industry turf war’ or ‘public health crisis’? Federal push to regulate kratom fuels debate in California. – Politico

Is California at a Crossroads: Industry Turf War or Urgent Public Health Crisis in the Kratom Debate?

August 1, 2025
Senate bill to ban lawmaker stock trading moves step forward – and Trump turns on Hawley – CNN

Senate Bill to Ban Lawmaker Stock Trading Gains Momentum Amid Trump’s Criticism of Hawley

August 1, 2025
Hungary to Gain Access to Cutting-Edge US Nuclear Technology – Hungarian Conservative

Hungary Poised to Unleash Cutting-Edge US Nuclear Technology

July 31, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (748)
  • Economy (773)
  • Entertainment (21,652)
  • General (16,220)
  • Health (9,810)
  • Lifestyle (781)
  • News (22,149)
  • People (775)
  • Politics (782)
  • Science (15,986)
  • Sports (21,269)
  • Technology (15,751)
  • World (756)

Recent News

‘Enough is enough,’ say Global South bishops in climate letter – U.S. Catholic

Enough is Enough’: Global South Bishops Deliver Urgent Plea for Bold Climate Action

August 1, 2025
Science Central names new executive director – 21Alive

Science Central Welcomes New Executive Director to Lead Exciting Future

August 1, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version