* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, September 29, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

    Sate your hunger at DBA’s Taste of Downtown – Bakersfield.com

    Indulge Your Cravings at DBA’s Taste of Downtown!

    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Autonomous Solutions shows off cutting-edge technology for the public – Cache Valley Daily

    Autonomous Solutions Unveils Cutting-Edge Technology for the Public

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

    Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    TicketSmarter Fall Entertainment Guide – Eastern Illinois University Athletics

    Cardi B Adds More Dates to Little Miss Drama Tour: ‘Y’all Making Me Work’ – Yahoo

    Cardi B Extends Little Miss Drama Tour: “Y’all Making Me Work

    ‘Today’: Sheinelle Jones Thanks Katie Couric for Support After Husband’s Death – CBS 19 News

    Sheinelle Jones Expresses Heartfelt Thanks to Katie Couric for Support After Husband’s Passing

    Sate your hunger at DBA’s Taste of Downtown – Bakersfield.com

    Indulge Your Cravings at DBA’s Taste of Downtown!

    Caesars Entertainment (CZR): Assessing Valuation After Times Square Casino Setback and Mounting Investor Concerns – simplywall.st

    Caesars Entertainment Faces Times Square Casino Hurdles as Investor Concerns Mount

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

    Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

    From shale to steam: Fossil fuel technology boosts clean geothermal energy – Washington Examiner

    From Shale to Steam: How Fossil Fuel Technology is Powering a Clean Geothermal Energy Revolution

    How Sustainable Technology is Shaping a Greener Future – Technology Magazine

    How Sustainable Technology is Driving the Revolution Toward a Greener Future

    Aurora police hope to add facial recognition technology to crime-fighting tools – CBS News

    Aurora Police Aim to Boost Crime-Fighting with New Facial Recognition Technology

    Autonomous Solutions shows off cutting-edge technology for the public – Cache Valley Daily

    Autonomous Solutions Unveils Cutting-Edge Technology for the Public

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Amazon to Pay $2.5 Billion in Prime Membership Settlement – The New York Times

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Scientists Reveal Molecular Secrets of Alzheimer’s Disease for the First Time

July 15, 2024
in Science
Scientists Reveal Molecular Secrets of Alzheimer’s Disease for the First Time
Share on FacebookShare on Twitter

Alzheimers Dementia Brain Disease Concept

Scientists have achieved a groundbreaking discovery in Alzheimer’s research by mapping the molecular structures within a human brain using cryo-electron tomography, focusing on key proteins β-amyloid and tau associated with dementia. This study, conducted at the University of Leeds and published in Nature, provides insights into how these proteins disrupt brain functions and could pave the way for new therapeutic approaches for neurological diseases.

Breakthrough Alzheimer’s research reveals the detailed molecular structure of key brain proteins, offering new insights for potential targeted therapies.

Scientists researching Alzheimer’s disease have, for the first time, uncovered the structure of molecules within a human brain. The findings, published in Nature, detail how researchers utilized cryo-electron tomography, assisted by fluorescence microscopy, to delve into the depths of a brain donated by an Alzheimer’s patient.

This gave 3-dimensional maps in which they could observe proteins, the molecular building blocks of life a million times smaller than a grain of rice, within the brain. The study zoomed in on two proteins that cause dementia– ‘β-amyloid’, a protein that forms microscopic sticky plaques, and ‘tau’ – another protein that in Alzheimer’s disease forms abnormal filaments that grow inside cells and spread throughout the brain.

Fluorescence Amyloid Image, 3D β Amyloid Architecture, In Tissue Tau Structures

Left, fluorescence image of amyloid in cryo-preserved post-mortem human brain. Middle, 3-dimensional molecular architecture of β-amyloid plaque. Right, in-tissue structure of tau filaments within post-mortem brain. Credit: University of Leeds

This study revealed the molecular structure of tau in tissue, how amyloids are arranged, and new molecular structures entangled within this pathology in the brain. Dementia is the leading cause of death in the UK, with Alzheimer’s its most common form.

Impact of Molecular Structures on Alzheimer’s

In Alzheimer’s disease, both β-amyloid plaques and abnormal tau filaments are thought to disrupt cellular communication, which leads to symptoms such as memory loss and confusion, and cell death.

Dr Rene Frank, lead author and Associate Professor in the University of Leeds’s School of Biology, said: “This first glimpse of the structure of molecules inside the human brain offers further clues to what happens to proteins in Alzheimer’s disease but also sets out an experimental approach that can be applied to better understand a broad range of other devastating neurological diseases.”

Over the past 70 years, a vast catalog of molecular structures has been accumulated by several thousand scientists across the globe, each working with proteins in isolation in a test tube. However, it has long been known that most functions in biology are the consequence of an orchestra of many different proteins.

This study carried out at the University of Leeds in collaboration with scientists at Amsterdam UMC, Zeiss Microscopy, and the University of Cambridge, is part of new efforts by structural biologists to study proteins directly within cells and tissues, their native environment – and how proteins work together and affect one another, particularly in human cells and tissues ravaged by disease. In the longer term it is hoped that observing this interplay of proteins within tissues will accelerate identifying new targets for next-generation mechanism-based therapeutics and diagnostics.

Reference: “CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain” by Madeleine A. G. Gilbert, Nayab Fatima, Joshua Jenkins, Thomas J. O’Sullivan, Andreas Schertel, Yehuda Halfon, Martin Wilkinson, Tjado H. J. Morrema, Mirjam Geibel, Randy J. Read, Neil A. Ranson, Sheena E. Radford, Jeroen J. M. Hoozemans and René A. W. Frank, 10 July 2024, Nature.
DOI: 10.1038/s41586-024-07680-x

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/scientists-reveal-molecular-secrets-of-alzheimers-disease-for-the-first-time/

Tags: RevealscienceScientists
Previous Post

Assembling the Cosmos: Hubble Reveals How Dwarf Galaxies Shape the Largest Galaxies

Next Post

Dissecting the Zoonotic Web: A New Model for Predicting Disease Spillover

Neighborhood Ecology Corps – RaleighNC.gov

Uncover How the Neighborhood Ecology Corps is Transforming Raleigh

September 28, 2025
A chemistry teacher’s approach to chocolate making: Meet Maram the STEM chocolatier – The Advocate

A chemistry teacher’s approach to chocolate making: Meet Maram the STEM chocolatier – The Advocate

September 28, 2025
The right stuff: New cohort of astronauts recruited by NASA – Digital Journal

The right stuff: New cohort of astronauts recruited by NASA – Digital Journal

September 28, 2025
‘Fallapalooza’ encourages active lifestyle for senior safety – WVIR

Fallapalooza Ignites Senior Spirit for Active and Safe Living

September 28, 2025
Why I gave the world wide web away for free | Tim Berners-Lee – The Guardian

Why I Decided to Make the World Wide Web Free for Everyone | Tim Berners-Lee

September 28, 2025
While chasing DK Metcalf, Isaiah Rodgers reached unprecedented speed – Yahoo Sports

Isaiah Rodgers Hits Unbelievable Top Speed While Chasing Down DK Metcalf

September 28, 2025
Poland bounce back with first ever World Championship bronze – Volleyball World

Poland Triumphs with Historic First-Ever World Championship Bronze in Volleyball

September 28, 2025

Russian Economy Struggles Under Growing Strain of Ukraine Conflict

September 28, 2025
Jussie Smollett Claims He Was ‘Disrespected’ on the ‘Special Forces’ Season Premiere – Yahoo

Jussie Smollett Opens Up About Feeling ‘Disrespected’ During the ‘Special Forces’ Season Premiere

September 28, 2025
Tom Holland shares health update after suffering concussion on ‘Spider-Man: Brand New Day’ set – New York Post

Tom Holland Opens Up About His Recovery After Concussion on ‘Spider-Man: Brand New Day’ Set

September 28, 2025

Categories

Archives

September 2025
M T W T F S S
1234567
891011121314
15161718192021
22232425262728
2930  
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (842)
  • Economy (862)
  • Entertainment (21,736)
  • General (17,298)
  • Health (9,905)
  • Lifestyle (875)
  • News (22,149)
  • People (864)
  • Politics (872)
  • Science (16,072)
  • Sports (21,362)
  • Technology (15,845)
  • World (844)

Recent News

Neighborhood Ecology Corps – RaleighNC.gov

Uncover How the Neighborhood Ecology Corps is Transforming Raleigh

September 28, 2025
A chemistry teacher’s approach to chocolate making: Meet Maram the STEM chocolatier – The Advocate

A chemistry teacher’s approach to chocolate making: Meet Maram the STEM chocolatier – The Advocate

September 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version