* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, August 7, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Themed Entertainment Design – Purdue Polytechnic

    Innovative Themed Entertainment Design: Creating Immersive Experiences

    Rachael Leigh Cook and Brandon Routh ‘Happy to Have Found Each Other’ Following Respective Divorces – yahoo.com

    Rachael Leigh Cook and Brandon Routh ‘Happy to Have Found Each Other’ Following Respective Divorces – yahoo.com

    ‘Billie Jean’ – Hyde Park Herald

    The Enduring Magic Behind ‘Billie Jean’ Revealed

    Hank Hill returns to a changed world in new ‘King of the Hill’ episodes – New Haven Register

    Hank Hill Navigates a Bold New World in Thrilling New ‘King of the Hill’ Episodes

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    BlackSky Technology Inc. (BKSY) Reports Q2 Loss, Lags Revenue Estimates – Yahoo Finance

    BlackSky Technology Inc. Reports Q2 Loss, Misses Revenue Targets

    Improved Technology Access: A Key to Closing the Healthcare Gap for African Americans – BIOENGINEER.ORG

    LMI Expands Technology Org, Appoints New Leaders – GovCon Wire

    LMI Expands Technology Team with Dynamic New Leadership Appointments

    Midland Innovation and Technology Charter School closing down – CBS News

    Midland Innovation and Technology Charter School Closes Permanently

    Future Trends In HR Technology – Dataconomy

    Future Trends In HR Technology – Dataconomy

    Nasdaq-listed Verb Technology to build $558 million TON treasury, rebrand as TON Strategy Co. – The Block

    Nasdaq-Listed Verb Technology to Build $558 Million TON Treasury and Rebrand as TON Strategy Co

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Themed Entertainment Design – Purdue Polytechnic

    Innovative Themed Entertainment Design: Creating Immersive Experiences

    Rachael Leigh Cook and Brandon Routh ‘Happy to Have Found Each Other’ Following Respective Divorces – yahoo.com

    Rachael Leigh Cook and Brandon Routh ‘Happy to Have Found Each Other’ Following Respective Divorces – yahoo.com

    ‘Billie Jean’ – Hyde Park Herald

    The Enduring Magic Behind ‘Billie Jean’ Revealed

    Hank Hill returns to a changed world in new ‘King of the Hill’ episodes – New Haven Register

    Hank Hill Navigates a Bold New World in Thrilling New ‘King of the Hill’ Episodes

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Exclusive | Fox Takes Stake in IndyCar Owner Penske Entertainment – The Wall Street Journal

    Go-to entertainment: why gaming was made for the toilet – The Guardian

    Why Gaming Is the Ultimate Way to Pass Time in the Bathroom

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    BlackSky Technology Inc. (BKSY) Reports Q2 Loss, Lags Revenue Estimates – Yahoo Finance

    BlackSky Technology Inc. Reports Q2 Loss, Misses Revenue Targets

    Improved Technology Access: A Key to Closing the Healthcare Gap for African Americans – BIOENGINEER.ORG

    LMI Expands Technology Org, Appoints New Leaders – GovCon Wire

    LMI Expands Technology Team with Dynamic New Leadership Appointments

    Midland Innovation and Technology Charter School closing down – CBS News

    Midland Innovation and Technology Charter School Closes Permanently

    Future Trends In HR Technology – Dataconomy

    Future Trends In HR Technology – Dataconomy

    Nasdaq-listed Verb Technology to build $558 million TON treasury, rebrand as TON Strategy Co. – The Block

    Nasdaq-Listed Verb Technology to Build $558 Million TON Treasury and Rebrand as TON Strategy Co

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Unlocking the Mysteries of Cell Structure With Cutting-Edge Imaging

April 17, 2024
in Science
Unlocking the Mysteries of Cell Structure With Cutting-Edge Imaging
Share on FacebookShare on Twitter

Genesis of Our Cellular Skeleton

Model of a human centriole cut along its longitudinal axis and viewed from above. Credit: © CentrioleLab

UNIGE scientists have reconstructed for the first time a film of the assembly of the human centriole, one of the essential structures that constitute our cells.

Cells contain various specialized structures — such as the nucleus, mitochondria, or peroxisomes — known as “organelles.” Tracing their genesis and determining their structure is fundamental to understanding cell function and the pathologies linked to their dysfunction. Scientists at the University of Geneva (UNIGE) have combined high resolution microscopy and kinematic reconstruction techniques to visualize, in motion, the genesis of the human centriole. This organelle, essential to the organization of the cell skeleton, is associated — in case of dysfunction — with certain cancers, brain disorders or retinal diseases. This work, published in the journal Cell, elucidates the complexities of centriole assembly. It also opens up many new avenues for the study of other cell organelles.

The Genesis of Our Cellular Skeleton, Image by Image

Organelle genesis proceeds according to a precise sequence of successive protein recruitment events. Visualizing this assembly in real-time provides a better understanding of the role of these proteins in organelle structure or function. However, obtaining a video sequence with sufficient resolution to distinguish such complex microscopic components faces a number of technical limitations.

Inflating Cells for Better Observation

This is particularly true of the centriole. This organelle, measuring less than 500 nanometers (half a thousandth of a millimeter), is constituted of around 100 different proteins organized into six substructural domains. Until a few years ago, it was impossible to visualize the structure of the centriole in detail. The laboratory of Paul Guichard and Virginie Hamel, co-directors of research in the Department of Molecular and Cellular Biology at the UNIGE Faculty of Science, has changed this situation by using the technique of expansion microscopy. This cutting-edge technique enables cells and their constituents to be progressively inflated without being deformed, so that they can then be observed — using conventional microscopes — with very high resolution.

Obtaining images of the centriole with such high resolution enables the exact location of proteins at a given time but gives no information on the order of appearance of substructural domains or of individual proteins. Marine Laporte, a former research and teaching fellow in the UNIGE group and first author of the study, used expansion microscopy to analyze the location of 24 proteins in the six domains in over a thousand centrioles at different stages of growth.

Reorganizing Images To Set Them in Motion

“This very tedious work was followed by a pseudo-temporal kinematic reconstruction. In other words, we were able to put these thousands of images taken at random during centriole biogenesis back into chronological order, to reconstruct the various stages in the formation of centriole substructures, using a computer analysis we developed,” explains Virginie Hamel, co-leader of the study.

This unique approach, which combines the very high resolution of expansion microscopy and kinematic reconstruction, has enabled us to model the first 4D assembly of the human centriole. “Our work will not only deepen our understanding of centriole formation, but also open up incredible prospects in cellular and molecular biology, since this method can be applied to other macromolecules and cellular structures to study their assembly in space and time,” concludes Paul Guichard.

Reference: “Time-series reconstruction of the molecular architecture of human centriole assembly” by Marine H. Laporte, Davide Gambarotto, Éloïse Bertiaux, Lorène Bournonville, Vincent Louvel, José M. Nunes, Susanne Borgers, Virginie Hamel and Paul Guichard, 10 April 2024, Cell.
DOI: 10.1016/j.cell.2024.03.025

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/unlocking-the-mysteries-of-cell-structure-with-cutting-edge-imaging/

Tags: mysteriesscienceUnlocking
Previous Post

AI Transforms Oil Field Operations With Predictive Analytics

Next Post

Stanford Medicine Unmasks the Surprising Instigators of Severe COVID in the Lungs

A quilt-themed exhibit is coming to NYC’s American Folk Art Museum this fall – Time Out Worldwide

Discover the Magic of Quilts: Don’t Miss This Captivating NYC Exhibit This Fall!

August 7, 2025
Maximizing pasture potential, the science behind multi-species grazing – Beef Magazine

Unlocking the Power of Multi-Species Grazing: Science-Backed Strategies to Maximize Pasture Potential

August 7, 2025
The Council for Responsible Nutrition announces Science in Session theme and lineup – Nutritional Outlook

Council for Responsible Nutrition Reveals Thrilling Science in Session Theme and Speaker Lineup

August 7, 2025
Alibaba Upgrades Taobao Lifestyle Experience with New Cross-platform Loyalty Program – Alizila

Alibaba Upgrades Taobao Lifestyle Experience with New Cross-platform Loyalty Program – Alizila

August 7, 2025
BlackSky Technology Inc. (BKSY) Reports Q2 Loss, Lags Revenue Estimates – Yahoo Finance

BlackSky Technology Inc. Reports Q2 Loss, Misses Revenue Targets

August 7, 2025
Sports card industry leaders on what’s working and why trust needs to be improved – The New York Times

Sports card industry leaders on what’s working and why trust needs to be improved – The New York Times

August 7, 2025
‘Icy cool’: How Claudia Sheinbaum is navigating Trump’s new world order – Politico

Icy Cool’: How Claudia Sheinbaum Is Navigating the Challenges of a New Global Era

August 7, 2025
The U.S. Economy Is Stumbling Badly – Washington Monthly

The U.S. Economy Confronts Major Challenges Ahead

August 7, 2025

SM Entertainment revenue up, concert earnings flat – IQ Magazine

August 7, 2025
Has the Trump administration made America healthier? – EWG

Did the Trump Administration Improve America’s Health?

August 7, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (759)
  • Economy (782)
  • Entertainment (21,659)
  • General (16,337)
  • Health (9,821)
  • Lifestyle (792)
  • News (22,149)
  • People (783)
  • Politics (791)
  • Science (15,995)
  • Sports (21,279)
  • Technology (15,762)
  • World (764)

Recent News

A quilt-themed exhibit is coming to NYC’s American Folk Art Museum this fall – Time Out Worldwide

Discover the Magic of Quilts: Don’t Miss This Captivating NYC Exhibit This Fall!

August 7, 2025
Maximizing pasture potential, the science behind multi-species grazing – Beef Magazine

Unlocking the Power of Multi-Species Grazing: Science-Backed Strategies to Maximize Pasture Potential

August 7, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version