* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, July 31, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

    Micro wrestling coming to NE Ohio – Cleveland.com

    Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

    Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

    That’s (Political) Entertainment: When Theatre Meets Politics

    Future Script: How Generative AI Is Changing Collective Bargaining in the Entertainment Industry – Jackson Lewis

    Future Script: How Generative AI Is Transforming Collective Bargaining in Entertainment

    The SBA’s live-entertainment bailout was supposed to end two years ago. We still don’t know how $1.5 billion was spent. – Yahoo Home

    $1.5 Billion Live-Entertainment Bailout: Two Years Later, Where Did the Money Go?

    Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, Boyd – CDC Gaming

    Top Wall Street Bets: Caesars, Golden Entertainment, Churchill Downs, GLPI, and Boyd Take Center Stage

    Micro wrestling coming to NE Ohio – Cleveland.com

    Get Ready, NE Ohio: Micro Wrestling Is Making Its Exciting Debut!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

    Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

    Revving Up The U.S. Technology Engine – Forbes

    Revving Up The U.S. Technology Engine – Forbes

    More than just a hockey player – Rochester Institute of Technology Athletics

    Beyond the Ice: The Inspiring Journey of a Remarkable Athlete from Rochester Institute of Technology

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    Smart Logistics in Warehousing – From Legacy Protocols to Green IoT – How Technology Is Reshaping the Sustainable Supply Chain – Logistics Viewpoints –

    AI’s race in the dark with China – Axios

    The High-Stakes AI Race: Innovation and Competition in the Shadows

    Eagle Unveils Revolutionary X-Ray Technology at Pack Expo

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Unraveling the Mysteries of Disordered Proteins

February 1, 2024
in Science
Unraveling the Mysteries of Disordered Proteins
Share on FacebookShare on Twitter

Abstract Protein Biochemistry Art Concept

A groundbreaking study by the University of Copenhagen has unveiled the properties of all 28,000 human disordered proteins, challenging traditional protein structure concepts and offering new insights into their role in diseases. Credit: SciTechDaily.com

Research reveals new insights into 28,000 human disordered proteins, altering our understanding of protein structures and functions.

Protein molecules lie at the heart of biology. Our typical understanding of proteins states that each type of protein has a specific three-dimensional shape that enables it to perform its function. This dogma is challenged by intrinsically disordered proteins which make up one-third of all proteins and have central biological functions even though their shapes are constantly changing. Until now, our understanding of the structural properties of this intriguing class of proteins has been based on studies of only a small number of examples.

Breakthrough Research on Disordered Proteins

In research published on January 31 in the journal Nature, researchers from the Department of Biology, University of Copenhagen have shown how all (approximately 28,000) disordered proteins in the human body behave.

“I have always been fascinated by intrinsically disordered proteins because they seem to defy most of the rules of how a protein should behave. For the last 20 years, we have worked on figuring out how these strange proteins look and whether new rules need to be applied to describe them. For the first time, we have now been able to study the structure of all human disordered proteins and begun to provide order into this world of molecular disorder,” says Professor Kresten Lindorff-Larsen, director of the NNF center, PRISM, in which the research was performed.

PRISM Center’s Research Approach

The goal of the PRISM center is to combine computational methods from biophysics and machine learning, with methods from cell biology to study how genetic variants cause disease. But until now, the researchers did not know how most disordered proteins looked, and hence could not even begin to study how mutations in the genes encoding for them might be able to cause disease.

“Until recently, we examined the disordered proteins one-by-one, and it was essential to find a way to study them on a larger scale,” says Assistant Professor Giulio Tesei, who is one of the lead authors of the new paper. Giulio continues: “We came up with an approach where we could use experimental measurements on disordered proteins to develop a computational model to predict their properties. Since this model is both accurate and fast, we can now look at them all.”

Student-Led Contributions and Project Impact

Remarkably, the study was co-led by bachelor student, Anna Ida Trolle, who says: “When I started the project, I didn’t know that you typically just study one or two proteins at a time. So, when Giulio and Kresten suggested that I should study some 28,000 proteins, I, fortunately, didn’t realize how crazy an idea it was. However, we quickly found a way to generate and keep track of the large amount of data and were able to use it to study the biology and evolution of disordered proteins.

Kresten Lindorff-Larsen concludes: “This has been a challenging but also an extremely fun project, that was only made possible by the contributions of several people with diverse expertise in the PRISM center. We have made new steps on linking the molecular properties of disordered proteins to their biological function and roles in disease. Finally, we are beginning to understand the language of disordered proteins.”

Reference: “Conformational ensembles of the human intrinsically disordered proteome” by Giulio Tesei, Anna Ida Trolle, Nicolas Jonsson, Johannes Betz, Frederik E. Knudsen, Francesco Pesce, Kristoffer E. Johansson and Kresten Lindorff-Larsen, 31 January 2024, Nature.
DOI: 10.1038/s41586-023-07004-5

The research was funded by the Novo Nordisk Foundation and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie: grant agreement No 101025063.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/unraveling-the-mysteries-of-disordered-proteins/

Tags: mysteriesscienceunraveling
Previous Post

Photonic Chips Blaze New Trails in Light Dynamics

Next Post

UTe2 Unleashes New Superconductivity Secrets

Some killer whales hunt in pairs to maximize their bounty – Science News

Some killer whales hunt in pairs to maximize their bounty – Science News

July 31, 2025
Be Like Blippi Week – Adventure Science Center

Join the Fun: Be Like Blippi Week at Adventure Science Center!

July 31, 2025
Martha Stewart questions Meghan Markle’s lifestyle brand: ‘Hope she knows what she’s talking about’ – Page Six

Martha Stewart Raises Eyebrows Over Meghan Markle’s Lifestyle Brand: “Hope She Knows What She’s Talking About

July 31, 2025
Trump Executive Order Ends De Minimis Exemption for Rest of World – The New York Times

Trump Executive Order Ends De Minimis Exemption for Rest of World – The New York Times

July 31, 2025
Mexico’s economy grew 0.7% in Q2, outpacing analysts’ forecasts – Mexico News Daily

Mexico’s economy grew 0.7% in Q2, outpacing analysts’ forecasts – Mexico News Daily

July 31, 2025
Sens. Blackburn, Warnock introduce CREATE Act to provide tax relief to music creators – Yahoo Home

Sens. Blackburn and Warnock Launch CREATE Act to Deliver Tax Relief for Music Creators

July 31, 2025
Malnutrition rates reach alarming levels in Gaza, WHO warns – World Health Organization (WHO)

Malnutrition rates reach alarming levels in Gaza, WHO warns – World Health Organization (WHO)

July 31, 2025
Ahead of Trade Deadline, Trump Threatens Canada for Backing Palestinian State – The New York Times

Trump Delivers Stark Warning to Canada Over Backing Palestinian State Ahead of Trade Deadline

July 31, 2025
Cognizant Technology Solutions Corp (CTSH) Q2 2025 Earnings Call Highlights: Strong Revenue … – Yahoo.co

Cognizant Q2 2025 Earnings: Impressive Revenue Growth and Key Takeaways

July 31, 2025
Pirates deal Ke’Bryan Hayes to Reds for reliever, prospect – altoonamirror.com

Pirates deal Ke’Bryan Hayes to Reds for reliever, prospect – altoonamirror.com

July 31, 2025

Categories

Archives

July 2025
MTWTFSS
 123456
78910111213
14151617181920
21222324252627
28293031 
« Jun    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (746)
  • Economy (772)
  • Entertainment (21,652)
  • General (16,208)
  • Health (9,809)
  • Lifestyle (780)
  • News (22,149)
  • People (774)
  • Politics (781)
  • Science (15,985)
  • Sports (21,269)
  • Technology (15,751)
  • World (755)

Recent News

Some killer whales hunt in pairs to maximize their bounty – Science News

Some killer whales hunt in pairs to maximize their bounty – Science News

July 31, 2025
Be Like Blippi Week – Adventure Science Center

Join the Fun: Be Like Blippi Week at Adventure Science Center!

July 31, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version