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Unraveling Tomato’s Genetic Mysteries: How Background Mutations Alter Outcomes

October 21, 2023
in Science
Unraveling Tomato’s Genetic Mysteries: How Background Mutations Alter Outcomes
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Tomato Plant Genetics

For millennia, evolution naturally mutated tomatoes, with humans later selecting preferred traits. Now, CRISPR genome editing allows even more precise changes. Researchers at Cold Spring Harbor Laboratory studied the predictability of breeding tomatoes with both natural and CRISPR-induced mutations. Their findings reveal that “background” mutations from evolutionary and agricultural history can significantly impact the outcome of engineered mutations. This emphasizes the need to understand and consider these background mutations when introducing new genetic changes.

For tens of thousands of years, evolution has shaped tomatoes through natural mutations. Once humans entered the picture, they spent centuries breeding tomatoes, selecting for their preferred traits. Today, CRISPR genome editing allows us to make new crop mutations that improve traits even further. However, individual mutations, whether natural or engineered, don’t work alone.

Each operates in a sea of thousands of so-called “background” mutations. These changes have been sowed by evolution and agricultural history. And what if just one could dramatically alter the desired outcome of an engineered mutation?

Study on Genetic Predictability in Tomatoes

Now, a plant geneticist and a computational scientist at Cold Spring Harbor Laboratory (CSHL) have teamed up to explore just how predictable plant breeding actually is with natural and CRISPR mutations. To do so, they turned back the evolutionary clock.

CSHL Professor & HHMI Investigator Zachary Lippman and Associate Professor David McCandlish wondered if different natural and engineered mutations could have similar effects on tomato size depending on the presence of two other gene mutations. Using CRISPR, they created a series of mutations in the SlCLV3 gene. (Natural mutation of this gene is known to increase fruit size.) They then combined those mutations with others in genes that work with SlCLV3.

Slclv3 Slcle9 Tomato

Cold Spring Harbor Laboratory scientists created a collection of over 40 tomato strains with natural and engineered mutations that affected fruit size. The strains were grown over several years and across several geographic locations, including Florida and Cold Spring Harbor, NY. Credit: Lippman lab/Cold Spring Harbor Laboratory

Altogether, they created 46 tomato strains with different combinations of mutations. They found the SlCLV3 mutations produced more predictable effects when certain other mutations were also present. Mutations in one gene produced predictable changes in tomato size, but mutations in another yielded random outcomes. Remarkably, the most beneficial effect involved two mutations that arose millennia ago and were central in tomato domestication.

Implications for Genome Editing

New research by McCandlish and Lippman may help us better understand genetic predictability. But one thing’s certain. Context matters when introducing new crop mutations. Lippman explains:

“Is genome editing a way to quickly bring in consumer benefits—better flavor, nutrition? The answer is probably yes. The question is how predictable is it going to be.”

A Collection of Tomatoes With Different Combinations of Artificial and Natural Mutations

A collection of tomatoes with different combinations of artificial and natural mutations. The mutations affected the number of locules, or seed pockets, resulting in different fruit sizes. Lyndsey Aguirre, a CSHL School of Biological Sciences graduate, led the project. Credit: Lippman lab/Cold Spring Harbor Laboratory

Lippman and McCandlish’s work suggests the role of background mutations demands reassessment. “The field will have to grapple with this as we start to make more highly engineered organisms,” says McCandlish. “Once you start making 10, 20 mutations, the probability of having unanticipated results may increase.”

Deciphering the Genetic Code of Evolution

The book of evolution has been written in all different languages, many of which we’re still learning. Plant genetics and computational biology offer two means of deciphering the text. Lippman and McCandlish hope their collaborative interpretation will help science meet the challenge. Looking ahead, it may also help humanity adapt crops to meet the ever-evolving needs of society.

Reference: “Idiosyncratic and dose-dependent epistasis drives variation in tomato fruit size” by Lyndsey Aguirre, Anat Hendelman, Samuel F. Hutton, David M. McCandlish and Zachary B. Lippman, 19 October 2023, Science.
DOI: 10.1126/science.adi5222

The study was funded by the National Science Foundation, the Hearst Foundations, the National Institutes of Health, the Alfred P. Sloan Foundation, and the Howard Hughes Medical Institute. 

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Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/unraveling-tomatos-genetic-mysteries-how-background-mutations-alter-outcomes/

Tags: scienceTomato’sunraveling
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