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AU2016319131B2
Transgenic animals (for example, pigs) lacking expression of alpha gal and incorporating and expressing at least four transgenes under the control of at least two promoters, which render them suitable donors for xenotransplantation, including organs, organ fragments, tissues and cells derived from these animals and their therapeutic use, and methods of making such animals.
Revivicor (Blacksburg, VA, USA)
Ayares DL, Phelps C
10/13/2022
US11424007B2
A method for predictive engineering of a sample derived from a genetically optimized non-human donor suitable for xenotransplantation into a human having improved quality or performance.
XenoTherapeutics (Boston, MA, USA), Alexis Bio (Boston, MA, USA)
Holzer P, Monroy RL, Ptitsyn A, Chang E, Adkins J, Brown T, Rogers K
8/23/2022
US11406690B2
Methods of generating multiplexed genetically modified animals, for example, porcine endogenous retrovirus (PERV)-inactivated pigs. Also, methods of improving the birth rate of multiplexed genetically modified animals. The PERV-free or PERV-reduced embryos may be grown into adult swine from which organs and/or tissues may be extracted and used for such purposes as xenotransplantation into non-porcine animals such as humans.
BioMarin Pharmaceutical (Novato, CA, USA), UCL Business (London), St. Jude Children’s Research Hospital (Memphis, TN, USA)
Colosi PC, Nathwani A, McIntosh J, Tuddenham E, Davidoff A
8/9/2022
US11284607B2
Transgenic donor animals (for example, pigs) that carry one or more human transgenes that are expressed only when the endogenous gene of the donor animal is knocked out shortly before a graft is harvested for transplantation. The animal’s cells, tissues and organs have a better long-term survival when transplanted into a human patient.
The Trustees of Columbia University (New York)
Sykes M
3/29/2022
US11179496B2
Donor animals, tissues and cells that are useful for xenotransplantation of vascularized xenografts and derivatives thereof; in particular, porcine animals, as well as tissue and cells derived from these, that lack any expression of functional α-1,3 galactosyltransferase (aGT) and express one or more additional transgenes.
Ayares D, Revivicor (Blacksburg, VA, USA)
Ayares D
11/23/2021
US10905799B2
A biological product for clinical xenotransplantation into a human and a method of preparing biological product for clinical xenotransplantation into a human.
XenoTherapeutics (Boston, MA, USA)
Holzer PW, Adkins J, Monroy RL, Chang EJ
2/2/2021
US10717991B2
A transgenic pig in which an immune rejection response is suppressed during xenotransplantation, wherein a gene encoding heme oxygenase-1 (HO-1) and a gene encoding tumor necrosis factor receptor 1-Fc (TNFR1-Fc) are simultaneously expressed and a gene encoding α-1,3-galactosyltransferase (GGTA1) is knocked out. Also, a method for producing the same.
Seoul National University R&DB Foundation (Seoul, S. Korea), Chong Kun Dang Pharmaceutical Corp. (Seoul, S. Korea)
Lee BC, Ahn C, Kim GA, Yeom SC, Kim SJ, Cho BL, Eun M, Lee SH, Hwang IC, Hong HJ
7/21/2020
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