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Zombie Neurons and the Secrets of Our Brain’s Error-Correcting Code

April 5, 2024
in Science
Zombie Neurons and the Secrets of Our Brain’s Error-Correcting Code
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Neuroscience Brain Signals Concept

A study highlights the cerebellum’s role in learning and movement through “zombie neurons,” uncovering how these functionally altered but alive neurons are vital for associative learning signals.

Nestled at the back of your head, the cerebellum is a brain structure that plays a pivotal role in how we learn, adapting our actions based on past experiences.

Yet the precise ways in which this learning happens are still being defined. A study led by a team at the Champalimaud Foundation brings new clarity to this debate, with a serendipitous finding of so-called “zombie neurons.” These neurons, alive but functionally altered, have helped to advance our understanding of the cerebellum’s critical teaching signals.

The word “cerebellum” means “little brain,” despite the fact that it holds more than half the brain’s neurons. It is essential for coordinating movements and balance, helping you perform everyday tasks smoothly, like walking down a crowded street, or playing sports.

It is also crucial for the learning process that allows you to associate sensory cues with specific actions. Every time you pick up a cup without spilling its contents, effortlessly adjusting the amount of force you apply based on the weight of the container and how full it is, you’re experiencing the consequences of the cerebellum’s ability to link visual signals with corresponding movement responses.

The brain’s “teaching signals”

For learning to take place, the cerebellum continuously monitors the outside world and the outcome of movements that we make within it. When we make a mistake, information about our errors can be used to adjust the strength of brain connections, leading over time to changes in our behavioral responses to specific cues.

However, it is not known exactly how such “error” or “teaching signals” are represented within the brain to drive learned changes in behavior. The latest research from the Champalimaud Foundation’s Carey Lab, published in Nature Neuroscience, provides compelling evidence that activity in a specific class of cerebellar inputs, called climbing fibers, are absolutely essential for associative learning to occur.

To examine the role of climbing fibers and their targets, cerebellar Purkinje cells, in learning, the researchers designed an experiment involving mice. They used a common learning task known as eyeblink conditioning. In this task, a mouse learns to blink in response to a certain signal, such as a light, which precedes an event, typically a gentle puff of air aimed at its eye. The animals then display associative learning, learning to link a sensory signal with an adaptive movement response, in this case, blinking.

Climbing Fibers, in the Form of Ivy, Wrap Around the Branches of a Purkinje Cell Shaped Tree

Climbing fibers, in the form of ivy, wrap around the branches of a Purkinje cell-shaped tree, within the vibrant courtyard of a school populated by mice. The illustration captures the essential role of climbing fibers as teaching signals for associative cerebellar learning. Credit: Rita Felix

“In our experiment,” explains Dr. Tatiana Silva, the study’s first author, “we used a technique called optogenetics. This method functions like a highly precise remote control for brain cells, using light to turn on or off certain cells of interest at extremely specific times.” Silva continues, “Climbing fibers normally respond to sensory stimuli like a puff of air to the eye. By precisely activating these fibers with optogenetics, we were able to trick the mouse into thinking it had received an air puff, when in fact it had not. After we consistently stimulated climbing fibers during the presentation of a visual cue, the mice learned to blink in response to that cue – even in the absence of stimulation. This proved that these fibers are sufficient to drive this type of associative learning.”

The authors were further able to show that climbing fibers are also necessary for associative learning. “When we used optogenetics to selectively silence climbing fibers during the presentation of an actual air puff,” Silva reveals, “the mice completely failed to learn to blink in response to the visual cue.” Carey’s team similarly manipulated a number of other types of brain cells within the cerebellum, but found that none of them were able to provide such reliable teaching signals for learning.

The Emergence of “Zombie Neurons”

Looking more closely at some of their data, the researchers discovered an unexpected twist. In order to manipulate climbing fiber activity using optogenetics, they had used genetic tools to express a light-sensitive protein called Channelrhodopsin-2 (ChR2) in those neurons. Surprisingly, they found that when they tried to teach the ChR2-expressing mice using the traditional air puff method, the animals completely failed to learn. As Carey explains, after systematic recordings of neural activity from the cerebella of these mice, “It turned out that introducing ChR2 into the climbing fibers altered their natural properties, preventing them from responding appropriately to standard sensory stimuli like air puffs. This, in turn, completely blocked the animals’ ability to learn”.

“The remarkable thing,” says Silva, “was that these same mice learned perfectly well when we paired climbing fiber stimulation, instead of an air puff, to a visual cue.” Unintentionally, the team had achieved a long-standing objective in neuroscience: to modulate specific patterns of activity within specific neurons without entirely shutting down their communication, resulting in a more natural intervention to elucidate their causal role. In other words, although the climbing fibers remained spontaneously active and were clearly otherwise functional, their altered encoding of sensory stimuli left animals totally unable to learn the task. This led Silva to dub them “zombie neurons”: functionally alive but not interacting with the brain circuit as usual.

Due to the subtlety of the unexpected effects of ChR2 expression in climbing fibers, Dr. Megan Carey says, “These results serve as the most compelling evidence to date that climbing fiber signals are essential for cerebellar associative learning. Our next steps involve understanding why ChR2 expression leads to the ‘zombification’ of neurons and determining whether our findings extend to other forms of cerebellar learning”. Even the undead, it seems, have something to teach us about the world of the living

Reference: “Climbing fibers provide essential instructive signals for associative learning” by N. Tatiana Silva, Jorge Ramírez-Buriticá, Dominique L. Pritchett and Megan R. Carey, 2 April 2024, Nature Neuroscience.
DOI: 10.1038/s41593-024-01594-7

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Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/zombie-neurons-and-the-secrets-of-our-brains-error-correcting-code/

Tags: neuronsscienceZombie
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