X chromosome: How genetics becomes egalitarian. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Even for the strongest allele-disease associations, only a minority of the carriers of the allele develop the disease.
How can we get around this difference? The former is termed insulin-dependent diabetes mellitus, the latter non-insulin-dependent diabetes mellitus. Multiple etiologies for Alzheimer disease are revealed by segregation analysis. Evidence concerning the inadequacy of mutation as an explanation of the frequency of the sickle cell gene in the Belgian Congo.
Mask Up! Whereas a single very specific mutation of the beta globin locus produces the sickling trait, with respect to the GPD protein, many different mutations affect the amount in which the enzyme occurs and the efficiency of its action. Publication No.
In this Page. The data on black-white differences in the frequency of Alzheimer's disease are scanty but favor a lower incidence of Alzheimer's in blacks de al Monte et al. This means that the son cannot possibly inherit a colorblind allele if the mother is genotypically normal. Page LB.
Privacy Policy. In order for the trait to show up in an individual, BOTH parents must be carriers of the disease at least 1 sickle cell gene must be present. Many sex-linked genes are found on the X chromosome. What will happen if the y chromosome of a male meets the x chromosome of a female?
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Here would seem to be a clear example of an ethnic difference in susceptibility to a disease as great as the sickle cell example. X chromosome: How genetics becomes egalitarian. Each of these loci is highly polymorphic; at last count, the number of established alleles at each locus varied from 18 to 60 for the A, B, and C loci and from 4 to 58 for the 6 D sub-loci, and the number is still growing.
As we come to better understand the molecular genetics for these predispositions, it will be of interest to see how this hypothesis plays out. External link.