* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Thursday, August 28, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    ‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

    SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

    Do you have a favorable or an unfavorable opinion of Taylor Swift? – YouGov

    Do You Love Taylor Swift or Not? Share Your Thoughts!

    Upload Season 4 Review – yahoo.com

    Upload Season 4 Review: A Thrilling New Chapter Unveiled

    ‘The Roses’ review: Olivia Colman, Benedict Cumberbatch sparkle in dark comedy – Yakima Herald-Republic

    The Roses’ Review: Olivia Colman and Benedict Cumberbatch Shine in Dark Comedy Delight

    ‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

    When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

    Quotes of the Week: Peacemaker, Project Runway, Countdown and More – yahoo.com

    This Week’s Most Memorable Quotes from Peacemaker, Project Runway, Countdown, and More!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ITSWC 2025: Thursday sessions guide – Traffic Technology Today

    Your Ultimate Guide to Thursday Sessions at ITSWC 2025

    MC Machinery Technology Summit Showcases Manufacturing Innovations – Modern Machine Shop

    MC Machinery Technology Summit Unveils Cutting-Edge Manufacturing Innovations

    US-ROK Technology Cooperation Faces Rising Tensions – The National Interest

    Rising Tensions Put US-South Korea Technology Partnership to the Test

    The Role of AI and Technology in Shaping the Future of Interactive Entertainment – Technology Org

    How AI and Technology Are Transforming the Future of Interactive Entertainment

    Ten upcoming sports stadiums where technology takes to the field – Dezeen

    10 Futuristic Sports Stadiums Revolutionizing the Game with Cutting-Edge Technology

    Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

    Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    ‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

    SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

    Do you have a favorable or an unfavorable opinion of Taylor Swift? – YouGov

    Do You Love Taylor Swift or Not? Share Your Thoughts!

    Upload Season 4 Review – yahoo.com

    Upload Season 4 Review: A Thrilling New Chapter Unveiled

    ‘The Roses’ review: Olivia Colman, Benedict Cumberbatch sparkle in dark comedy – Yakima Herald-Republic

    The Roses’ Review: Olivia Colman and Benedict Cumberbatch Shine in Dark Comedy Delight

    ‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

    When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

    Quotes of the Week: Peacemaker, Project Runway, Countdown and More – yahoo.com

    This Week’s Most Memorable Quotes from Peacemaker, Project Runway, Countdown, and More!

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    ITSWC 2025: Thursday sessions guide – Traffic Technology Today

    Your Ultimate Guide to Thursday Sessions at ITSWC 2025

    MC Machinery Technology Summit Showcases Manufacturing Innovations – Modern Machine Shop

    MC Machinery Technology Summit Unveils Cutting-Edge Manufacturing Innovations

    US-ROK Technology Cooperation Faces Rising Tensions – The National Interest

    Rising Tensions Put US-South Korea Technology Partnership to the Test

    The Role of AI and Technology in Shaping the Future of Interactive Entertainment – Technology Org

    How AI and Technology Are Transforming the Future of Interactive Entertainment

    Ten upcoming sports stadiums where technology takes to the field – Dezeen

    10 Futuristic Sports Stadiums Revolutionizing the Game with Cutting-Edge Technology

    Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

    Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Technology

Antibiotic Identified by AI

October 17, 2023
in Technology
Antibiotic Identified by AI
Share on FacebookShare on Twitter

Computational approaches are emerging as powerful tools for the discovery of antibiotics. A study now uses machine learning to discover abaucin, a potent antibiotic that targets the bacterial pathogen Acinetobacter baumannii.

Traditionally, antibiotics were discovered by the screening of soil microorganisms, seeking secondary metabolites. From these initial molecules, numerous derivatives were synthesized, showing improved bioactivities and greater potential to meet clinical standards. Until recently, discovery efforts relied on the painstaking screening of large compound libraries for antibiotic activity1. Phenotypic screening approaches do not require advanced knowledge of the mechanism of action; however, the extensive and unexplored chemical space in the search for drug-like molecules poses considerable challenges, as the screening of numerous potential combinations (of both compounds and different bacterial strains) is both expensive and time-consuming. Thus, the discovery process of a new antibiotic has consistently depended on chance and serendipity. Recent advances that incorporate cutting-edge artificial intelligence (AI) and other computational approaches have demonstrated remarkable success in accelerating the identification of new drugs with desired properties2,3,4,5,6,7,8,9,10. Reporting in Nature Chemical Biology, Liu et al.11 have applied a machine learning algorithm to rapidly predict the antimicrobial activity of molecules against the Gram-negative pathogen Acinetobacter baumannii — which is a cause of nosocomial (hospital-derived) infections.

This is a preview of subscription content, access via your institution

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

269,00 € per year

only 22,42 € per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Log in

Learn about institutional subscriptions

Read our FAQs

Contact customer support

Fig. 1: The discovery of abaucin driven by machine learning.

References

Wright, G. D. Nat. Prod. Rep. 34, 694–701 (2017).

Article 
CAS 
PubMed 

Google Scholar 

Porto, W. F. et al. Nat. Commun. 9, 1490 (2018).

Article 
PubMed 
PubMed Central 

Google Scholar 

Torres, M. D. T. et al. Nat. Biomed. Eng. 6, 1451–1451 (2022).

Article 
PubMed 

Google Scholar 

Cesaro, A. et al. ACS Nano. 16, 1880–1895 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Das, P. et al. Nat. Biomed. Eng. 5, 613–623 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Sberro, H. et al. Cell 178, 1245–1259.e14 (2019).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Maasch, J. R. M. A., Torres, M. D. T., Melo, M. C. R. & de la Fuente-Nunez, C. Cell Host Microbe 31, 1260–1274.e6 (2023).

Article 
CAS 
PubMed 

Google Scholar 

Ma, Y. et al. Nat. Biotechnol. 40, 921–931 (2022).

Article 
CAS 
PubMed 

Google Scholar 

Wong, F., de la Fuente-Nunez, C. & Collins, J. J. Science 381, 164–170 (2023).

Article 
CAS 
PubMed 

Google Scholar 

Torres M. D. T. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.08.31.555711 (2023).

Liu, G. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01349-8 (2023).

Article 
PubMed 
PubMed Central 

Google Scholar 

Stokes, J. M. et al. Cell 180, 688–702.e13 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Jin, W. et al. Proc. Natl Acad. Sci. USA 118, e2105070118 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Preuer, K. et al. Bioinformatics 34, 1538–1546 (2018).

Article 
CAS 
PubMed 

Google Scholar 

Bran, A. M., Cox, S., White, A. D. & Schwaller, P. Preprint at https://doi.org/10.48550/arXiv.2304.05376 (2023).

Download references

Author information

Authors and Affiliations

Machine Biology Group, Departments of Psychiatry and Microbiology, Institute for Biomedical Informatics, Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Angela Cesaro & Cesar de la Fuente-Nunez

Departments of Bioengineering and Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA

Angela Cesaro & Cesar de la Fuente-Nunez

Penn Institute for Computational Science, University of Pennsylvania, Philadelphia, PA, USA

Angela Cesaro & Cesar de la Fuente-Nunez

Corresponding author

Correspondence to
Cesar de la Fuente-Nunez.

Ethics declarations

Competing interests

C.F.-N. provides consulting services to Invaio Sciences and is a member of the scientific advisory boards of Nowture S.L. and Phare Bio. The de la Fuentel lab has received research funding or in-kind donations from United Therapeutics, Strata Manufacturing PJSC, and Procter & Gamble, none of which were used in support of this work.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cesaro, A., de la Fuente-Nunez, C. Antibiotic identified by AI.
Nat Chem Biol (2023). https://doi.org/10.1038/s41589-023-01448-6

Download citation

Published: 11 October 2023

DOI: https://doi.org/10.1038/s41589-023-01448-6

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Hacker News – https://www.nature.com/articles/s41589-023-01448-6

Tags: AntibioticIdentifiedtechnology
Previous Post

Ford lays off 700 who were building electric version of F-150

Next Post

The Salmon on Your Plate Has a Troubling Cost. These Farms Offer Hope

Ecological Concerns – The Portugal News

Rising Ecological Concerns Threaten Portugal’s Natural Heritage

August 28, 2025
Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

August 28, 2025
Posco student volunteers take science projects abroad – The Korea Herald

Posco Student Volunteers Ignite Curiosity with Science Projects in Communities Abroad

August 28, 2025
Mediterranean diet with lifestyle changes lowers diabetes risk by 31% – News-Medical

Adopting a Mediterranean Diet and Lifestyle Cuts Diabetes Risk by 31%

August 28, 2025
ITSWC 2025: Thursday sessions guide – Traffic Technology Today

Your Ultimate Guide to Thursday Sessions at ITSWC 2025

August 28, 2025
Real Madrid Graduate School Universidad Europea and UNO Launch Dual Degree in Sports Management – University of Nebraska Omaha

Real Madrid Graduate School and UNO Launch Exciting New Dual Degree in Sports Management

August 28, 2025
Hamburg Township baton twirlers capture world championship title in Italy – WXYZ Channel 7

Hamburg Township Baton Twirlers Triumph as World Champions in Italy

August 28, 2025
Diversification helps Minnesota farm navigate ag economy slump – Brownfield Ag News

How Diversification is Powering a Minnesota Farm’s Success During Tough Agricultural Times

August 28, 2025
‘SNL’ Parts Ways With Emil Wakim Amid Rumored Season 51 Cast Shakeup – yahoo.com

SNL Shakes Up Season 51 Cast with Emil Wakim’s Surprising Exit

August 28, 2025
CDC Director Susan Monarez ousted, four other leaders quit health agency – CNBC

Top Health Officials Resign Amid Controversy as CDC Director Susan Monarez Is Ousted

August 28, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (794)
  • Economy (813)
  • Entertainment (21,692)
  • General (16,717)
  • Health (9,854)
  • Lifestyle (827)
  • News (22,149)
  • People (814)
  • Politics (821)
  • Science (16,023)
  • Sports (21,312)
  • Technology (15,794)
  • World (795)

Recent News

Ecological Concerns – The Portugal News

Rising Ecological Concerns Threaten Portugal’s Natural Heritage

August 28, 2025
Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

Scientists warn ocean-based climate fixes lack rules and oversight – Mongabay

August 28, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version