* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, October 15, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    Bluesman James Montgomery Will Perform In Falmouth – CapeNews.net

    Blues Legend James Montgomery Ready to Ignite the Stage in Falmouth

    Mexican singer Pedro Fernández to make Ave Fénix tour stop in Stockton. Tickets, schedule – Yahoo

    Mexican Singer Pedro Fernández Brings the Ave Fénix Tour to Stockton – Don’t Miss It!

    Flutter Entertainment’s SWOT Analysis: Uncovering the Growth Potential Amid Challenges

    Dylan Efron Shares Sweet ‘DWTS’ Rehearsal Photos Featuring His Little Sister Olivia – yahoo.com

    Dylan Efron’s Heartwarming ‘DWTS’ Rehearsal Moments with Little Sister Olivia

    Diane Keaton, Oscar-Winning Star of ‘Annie Hall’ and ‘The Godfather,’ Dies at 79 – Yahoo

    Diane Keaton, Oscar-Winning Star of ‘Annie Hall’ and ‘The Godfather,’ Dies at 79 – Yahoo

    THE VAMPIRE LESTAT Shares First Look Teaser Trailer (And It’s Fangtastic) – Yahoo

    THE VAMPIRE LESTAT Shares First Look Teaser Trailer (And It’s Fangtastic) – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Tracking DNA and RNA Together To Unlock Disease Insights – Technology Networks

    Unlocking Disease Insights by Tracking DNA and RNA Together

    The future of battery technology – Engineer Live

    Revolutionizing Energy: Exploring the Future of Battery Technology

    How Can Boosting Your Travel Experience with Less Technology Lead to a More Relaxing Vacation? All You Need to Know About This Latest Trend – Travel And Tour World

    How Can Boosting Your Travel Experience with Less Technology Lead to a More Relaxing Vacation? All You Need to Know About This Latest Trend – Travel And Tour World

    Davenport CornCon Cybersecurity Conference helps students explore technology, AI use – KWQC

    Davenport CornCon Cybersecurity Conference Ignites Student Passion for Technology and AI Innovations

    Inside Europe’s military technology resurgence – NBC News

    Europe’s Bold Comeback: Unveiling the Rise of Cutting-Edge Military Technology

    Vicor Corporation: Great Technology, Execution Trapped In Time (NASDAQ:VICR) – Seeking Alpha

    Vicor Corporation: Innovative Technology Hindered by Lackluster Execution

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    Bluesman James Montgomery Will Perform In Falmouth – CapeNews.net

    Blues Legend James Montgomery Ready to Ignite the Stage in Falmouth

    Mexican singer Pedro Fernández to make Ave Fénix tour stop in Stockton. Tickets, schedule – Yahoo

    Mexican Singer Pedro Fernández Brings the Ave Fénix Tour to Stockton – Don’t Miss It!

    Flutter Entertainment’s SWOT Analysis: Uncovering the Growth Potential Amid Challenges

    Dylan Efron Shares Sweet ‘DWTS’ Rehearsal Photos Featuring His Little Sister Olivia – yahoo.com

    Dylan Efron’s Heartwarming ‘DWTS’ Rehearsal Moments with Little Sister Olivia

    Diane Keaton, Oscar-Winning Star of ‘Annie Hall’ and ‘The Godfather,’ Dies at 79 – Yahoo

    Diane Keaton, Oscar-Winning Star of ‘Annie Hall’ and ‘The Godfather,’ Dies at 79 – Yahoo

    THE VAMPIRE LESTAT Shares First Look Teaser Trailer (And It’s Fangtastic) – Yahoo

    THE VAMPIRE LESTAT Shares First Look Teaser Trailer (And It’s Fangtastic) – Yahoo

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Tracking DNA and RNA Together To Unlock Disease Insights – Technology Networks

    Unlocking Disease Insights by Tracking DNA and RNA Together

    The future of battery technology – Engineer Live

    Revolutionizing Energy: Exploring the Future of Battery Technology

    How Can Boosting Your Travel Experience with Less Technology Lead to a More Relaxing Vacation? All You Need to Know About This Latest Trend – Travel And Tour World

    How Can Boosting Your Travel Experience with Less Technology Lead to a More Relaxing Vacation? All You Need to Know About This Latest Trend – Travel And Tour World

    Davenport CornCon Cybersecurity Conference helps students explore technology, AI use – KWQC

    Davenport CornCon Cybersecurity Conference Ignites Student Passion for Technology and AI Innovations

    Inside Europe’s military technology resurgence – NBC News

    Europe’s Bold Comeback: Unveiling the Rise of Cutting-Edge Military Technology

    Vicor Corporation: Great Technology, Execution Trapped In Time (NASDAQ:VICR) – Seeking Alpha

    Vicor Corporation: Innovative Technology Hindered by Lackluster Execution

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Bilateral Mastectomy Reduces Contralateral Breast Cancer Risk, but Not Mortality

July 30, 2024
in Health
Bilateral Mastectomy Reduces Contralateral Breast Cancer Risk, but Not Mortality
Share on FacebookShare on Twitter

Treating unilateral breast cancer with a bilateral mastectomy substantially reduced the risk of contralateral breast cancer compared with unilateral mastectomy or lumpectomy, yet not breast cancer mortality, according to a cohort study.

Over 20 years of follow-up in three matched groups totalling more than 108,000 women, contralateral breast cancers occurred in about 2% of the unilateral mastectomy and lumpectomy groups versus 0.3% of the bilateral mastectomy group, reported Steven Narod, MD, of Women’s College Hospital in Toronto, and colleagues.

Once a patient experienced a contralateral breast cancer, their subsequent risk of breast cancer mortality increased fourfold, yet preventing contralateral cancer through preemptive surgery did not appear to reduce the risk of death over the long term, they detailed in JAMA Oncology.

Across the three groups, there was no appreciable difference in breast cancer mortality rates at 20 years: 9.1% died of breast cancer in the unilateral mastectomy group, and 8.5% died in both the lumpectomy and bilateral mastectomy groups.

“It is generally presumed that a contralateral breast cancer is a new primary tumor with the potential to metastasize,” the researchers wrote. “Our findings question this interpretation. If the increase in deaths after a contralateral breast cancer were due to metastasis of the second cancer, we would expect bilateral mastectomy to be beneficial.”

Overall, the cumulative breast cancer mortality rate was 32.1% at 15 years for patients developing a contralateral cancer and 14.5% for those who did not develop a contralateral cancer (HR 4.00, 95% CI 3.52-4.54).

“The findings of this cohort study indicate that women with unilateral breast cancer should be advised that bilateral mastectomy greatly reduces the risk of a second cancer, but does not affect mortality,” Narod and colleagues concluded.

In an editorial accompanying the study, Seema Ahsan Khan, MD, and Masha Kocherginsky, PhD, both of Northwestern University Feinberg School of Medicine in Chicago, said that the study’s findings are consistent with the literature.

However, the finding that breast cancer mortality risk was substantially higher among women who developed a contralateral breast cancer is a “disturbing finding … particularly for patients,” they suggested. “Therefore, caution is needed when interpreting these analyses.”

Khan and Kocherginsky also noted that the issues of preference and risk tolerance will vary among patients.

“There are certainly those who, with a good understanding of the risks and quality of life problems associated with [bilateral mastectomy] with or without reconstruction, would prefer to avoid both the imaging experience of breast surveillance and the burden of undergoing treatment for a second breast cancer (even if highly likely to be cured),” they wrote. “The education of patients as well as surgeons regarding the risks and benefits of [bilateral mastectomy] is a continuing and necessary endeavor given existing interventions have not impacted the rates of contralateral phylactic mastectomy.”

For this study, Narod and colleagues used the National Cancer Institute’s SEER Program registry database to evaluate survival outcomes of women diagnosed with unilateral stage 0 to III breast cancer (invasive and ductal carcinoma in situ) from 2000 to 2019. The study sample included 661,270 women (mean age 58.7 years). After matching according to surgical approach, there were 36,028 women in each of the three groups.

The authors found that the hazard ratio for dying of breast cancer was higher for women initially treated for ductal carcinoma in situ (HR 10.30, 95% CI 5.17-20.49) compared with women initially treated for invasive cancer (HR 4.04, 95% CI 3.54-4.60).

In addition, the hazard ratio for breast cancer mortality was similar for time from primary diagnosis to contralateral breast cancer for all matched patients. After experiencing a contralateral breast cancer in the first 5 years, the hazard ratio was 3.89 (95% CI 3.36-4.49); in 5 to 10 years, it was 4.12 (95% CI 3.24-5.23); and in 10 to 15 years, it was 4.48 (95% CI 2.73-7.35).

The hazard ratio for breast cancer mortality slightly declined with increasing age at diagnosis of the contralateral cancer (30-39 years: HR 5.16, 95% CI 3.17-8.39; 40-64 years: HR 4.19, 95% CI 3.62-4.84; 65 years and older: HR 3.25, 95% CI 2.55-4.14).

The authors acknowledged their study had limitations. For example, they did not have data on the use of endocrine therapy, which may have affected the risks of contralateral cancer among patients with estrogen receptor-positive breast cancer, nor did they have data on family history or whether the patients had BRCA1 or BRCA2 mutations, which would have put them at higher risk of contralateral breast cancer.

author['full_name']

Mike Bassett is a staff writer focusing on oncology and hematology. He is based in Massachusetts.

Disclosures

This research was supported by the Peter Gilgan Centre for Women’s Cancers at Women’s College Hospital in partnership with the Canadian Cancer Society. Study authors were supported by a 2023 PRiME-Women’s College Hospital Clinical Catalyst Program Award, the Canadian Cancer Society Chair in Breast Cancer Research at Women’s College Research Institute at Women’s College Hospital, and a 2024 New Investigator Award from the Terry Fox Research Institute.

Narod is the recipient of the Tier I Canada Research Chair in Breast Cancer. A co-author also reported personal fees from Conquer Cancer, the ASCO Foundation, Lobular Breast Cancer Alliance, Merck, and AstraZeneca.

Khan reported no conflicts of interest. Kocherginsky reported personal fees from the Robert A. Winn Diversity in Clinical Trials Award Program and from the LUNGevity Foundation, and a patent with royalties from Corcept Therapeutics and the University of Chicago.

Primary Source

JAMA Oncology

Source Reference: Giannakeas V, et al “Bilateral mastectomy and breast cancer mortality” JAMA Oncol 2024; DOI: 10.1001/jamaoncol.2024.2212.

Secondary Source

JAMA Oncology

Source Reference: Khan SA, Kocherginsky M “Contralateral breast cancer remains a complex biologic conundrum” JAMA Oncol 2024; DOI: 10.1001/jamaoncol.2024.2205.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : MedPageToday – https://www.medpagetoday.com/hematologyoncology/breastcancer/111287

Tags: BilateralhealthMastectomy
Previous Post

Statin Candidate Pool Shrinks if PREVENT Risk Calculator Is Put to Current Practice

Next Post

Alzheimer’s Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention

Preview: could Premier League fitness make the difference in recurve men? – World Archery

Could Premier League Fitness Be the Game-Changer for Recurve Men?

October 15, 2025
The $2.5 trillion ocean economy is at a crossroads. Capital must act now – Fortune

The $2.5 Trillion Ocean Economy at a Crossroads: Why Urgent Capital Investment Is Essential

October 15, 2025
Bluesman James Montgomery Will Perform In Falmouth – CapeNews.net

Blues Legend James Montgomery Ready to Ignite the Stage in Falmouth

October 15, 2025
30-year decline in Kansas health can be reversed with leadership, report finds – Kansas Reflector

30-year decline in Kansas health can be reversed with leadership, report finds – Kansas Reflector

October 15, 2025
Scorecard ranks Northwest politician as the most Trump-aligned Democrat in Congress – OregonLive.com

Northwest Politician Touted as the Most Trump-Aligned Democrat in Congress

October 14, 2025
CVYS reiterates ban on activities threatening ecology and public order – Nagaland Tribune

CVYS Takes a Strong Stand to Protect Ecology and Public Safety

October 14, 2025
Inaugural Implementation Science Symposium Highlights Excitement for Burgeoning Discipline – Geisel School of Medicine at Dartmouth

Inaugural Implementation Science Symposium Ignites Excitement for Emerging Field

October 14, 2025
Scientists find the brain’s hidden pulse that may predict Alzheimer’s – ScienceDaily

Scientists find the brain’s hidden pulse that may predict Alzheimer’s – ScienceDaily

October 14, 2025
You know you’re smarter than someone if these 10 thought patterns are obvious to you but not them – VegOut

10 Thought Patterns That Show You’re Smarter Than Most People

October 14, 2025
New Strider Report Reveals Scope and Scale of U.S. Academic Research Done in Collaboration with PLA-Affiliated Entities on STEM Technologies – PR Newswire

New Strider Report Reveals Widespread U.S. Academic Collaborations with PLA-Linked Entities in STEM Technologies

October 14, 2025

Categories

Archives

October 2025
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
« Sep    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (867)
  • Economy (889)
  • Entertainment (21,761)
  • General (17,598)
  • Health (9,931)
  • Lifestyle (901)
  • News (22,149)
  • People (889)
  • Politics (899)
  • Science (16,099)
  • Sports (21,388)
  • Technology (15,868)
  • World (872)

Recent News

Preview: could Premier League fitness make the difference in recurve men? – World Archery

Could Premier League Fitness Be the Game-Changer for Recurve Men?

October 15, 2025
The $2.5 trillion ocean economy is at a crossroads. Capital must act now – Fortune

The $2.5 Trillion Ocean Economy at a Crossroads: Why Urgent Capital Investment Is Essential

October 15, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version