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    Theater at Santa Fe’s San Isidro Plaza will be converted into IMAX, family entertainment venue – Santa Fe New Mexican

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    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

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    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

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    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

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    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    Simpson College to purchase medical simulation technology with grant funds – Iowa Capital Dispatch

    Simpson College to purchase medical simulation technology with grant funds – Iowa Capital Dispatch

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    Theater at Santa Fe’s San Isidro Plaza will be converted into IMAX, family entertainment venue – Santa Fe New Mexican

    Santa Fe’s San Isidro Plaza Theater Transforms into Exciting IMAX Family Entertainment Venue

    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

    B&B Theatres will open massive entertainment complex in Texas – The Business Journals

    Rough times for broadcast networks illustrate changing media landscape – New Haven Register

    Broadcast Networks Confront Turbulent Times in a Rapidly Changing Media Landscape

    Black River Entertainment Adds Traci Hite As Director Of Promotion, Southeast – MusicRow.com

    Black River Entertainment Welcomes Traci Hite as New Director of Southeast Promotion

    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

    Entertainment Business Master’s Grad Launched Nonprofit to Nurture Emerging Artists – Full Sail University

    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

    Review: At the Huntington, the New Hollywood String Quartet recalls legendary studio musicians – Los Angeles Times

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

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    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    A major AI training data set contains millions of examples of personal data – MIT Technology Review

    Simpson College to purchase medical simulation technology with grant funds – Iowa Capital Dispatch

    Simpson College to purchase medical simulation technology with grant funds – Iowa Capital Dispatch

    SailGP Technologies officially launches new center of excellence in technology & innovation – Sail-World.com

    SailGP Technologies officially launches new center of excellence in technology & innovation – Sail-World.com

    Victorville’s new gunfire-detecting technology already making strides, city says – NBC Los Angeles

    Victorville’s New Gunfire-Detecting Technology Is Already Making a Difference, City Officials Say

    Guest columnist: China cutting corners on technology – The State Journal

    China’s Rapid Tech Advances Spark Worries About Cutting Corners

    Sentrycs’ Cyber Over RF technology integrated into Rafael’s combat-proven Drone Dome system – Defence Industry Europe

    Sentrycs’ Cyber Over RF Technology Boosts Rafael’s Battle-Tested Drone Dome System

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Alzheimer’s Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention

July 30, 2024
in Health
Alzheimer’s Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention
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PHILADELPHIA — Blood tests for Alzheimer’s disease biomarkers may not only be useful for clinical diagnosis but could also make it possible to test preventive therapies in people not yet showing any signs of the condition, researchers said.

In a prospectively followed cohort of older people with normal cognition and low amyloid-β (Aβ) plaque burdens in their brains, baseline plasma levels of tau and Aβ protein species predicted the speed at which Aβ plaques accumulated over 5 years of follow-up, according to Oskar Hansson, MD, PhD, of Skåne University Hospital in Malmö, Sweden, and colleagues.

Specifically, participants with a low ratio of two Aβ amino acid forms (Aβ42/40) and high ratio of tau217 phosphorylation (i.e., tau with a phosphate molecule attached at the threonine-217 residue, %p-tau217) showed dramatically faster plaque accumulation, the researchers reported in JAMA Neurology. The study was also to be presented at the Alzheimer’s Association International Conference (AAIC).

The report followed one from many of the same researchers, also presented at AAIC, indicating that a model based on this same pair of biomarkers outperformed human doctors in diagnosing Alzheimer’s disease in people with cognitive deficits.

For people without such symptoms, or even with Aβ substantial plaque burdens, the findings could pave the way for “primary prevention” trials to identify drugs or other therapies that keep Aβ from accumulating in the brain. These would be targeted at individuals who, because of family history, genetic features, or other factors, are thought likely to develop Alzheimer’s disease down the line.

Such trials, which necessarily must enroll people with no cognitive deficits and low plaque burdens, are currently not feasible. If participants were simply plucked randomly from the general population, either huge numbers or decades of follow-up would be needed to determine whether a particular therapy was effectively preventing plaque buildup and, hopefully, Alzheimer’s disease.

But if a subpopulation likely to undergo rapid Aβ accumulation could be identified, then such trials could be shorter and wouldn’t need so many participants to confirm an effect. That’s where the Aβ42/40 and %p-tau217 blood test comes in.

The study drew primarily from the so-called BioFINDER-2 cohort study underway in Sweden, which enrolled cognitively normal older people from 2017 to 2022 and followed them with tests including periodic PET scans to evaluate brain Aβ plaque burden. Overall, the cohort included 495 people, among whom 384 had low plaque burdens (
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Tags: Alzheimer’sbiomarkershealth
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