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    Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

    Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

    Monumental Sports & Entertainment’s Samantha Brady on the Power of the RSN’s Direct-to-Consumer Streaming Service Monumental+ – Sports Video Group

    Samantha Brady Reveals How Monumental+ is Transforming Sports Streaming with Direct-to-Consumer Access

    Moses Singer Welcomes Entertainment and Intellectual Property Partner Frederick Bimbler – Yahoo Finance

    Moses Singer Expands Team with New Entertainment and Intellectual Property Partner Frederick Bimbler

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

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    Stallion Uranium Provides Update on Technology Data Acquisition Agreement – GlobeNewswire

    Stallion Uranium Announces Exciting Progress in Technology Data Acquisition Agreement

    2025 WE Local Prague Recap: Inspiring Women in Engineering and Technology – Society of Women Engineers

    2025 WE Local Prague Recap: Inspiring Women in Engineering and Technology – Society of Women Engineers

    SMPTE Opens Early Bird Registration for Media Technology Summit – TVTechnology

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    Google Fiber puts Nokia network slicing technology to the test – Fierce Network

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    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

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    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

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    Immersive sports and entertainment venue Cosm set to build its 5th location in Cleveland – WKYC

    Cosm Reveals Exciting Vision for Its 5th Immersive Sports and Entertainment Venue in Cleveland

    Monumental Sports & Entertainment’s Samantha Brady on the Power of the RSN’s Direct-to-Consumer Streaming Service Monumental+ – Sports Video Group

    Samantha Brady Reveals How Monumental+ is Transforming Sports Streaming with Direct-to-Consumer Access

    Moses Singer Welcomes Entertainment and Intellectual Property Partner Frederick Bimbler – Yahoo Finance

    Moses Singer Expands Team with New Entertainment and Intellectual Property Partner Frederick Bimbler

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Longhua District and Max-Matching Entertainments, supported by RWS Global forge strategic partnership to develop international IP-themed entertainment complex – Amusement Today

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Government whip to withdraw Entertainment Complex Bill on July 9 – Nation Thailand

    Magicians and Battlebots light up Las Vegas entertainment scene – KSNV

    Magicians and Battlebots Take Las Vegas Entertainment by Storm

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    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

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    Stallion Uranium Provides Update on Technology Data Acquisition Agreement – GlobeNewswire

    Stallion Uranium Announces Exciting Progress in Technology Data Acquisition Agreement

    2025 WE Local Prague Recap: Inspiring Women in Engineering and Technology – Society of Women Engineers

    2025 WE Local Prague Recap: Inspiring Women in Engineering and Technology – Society of Women Engineers

    SMPTE Opens Early Bird Registration for Media Technology Summit – TVTechnology

    SMPTE Launches Early Bird Registration for Exciting Media Technology Summit

    Google Fiber puts Nokia network slicing technology to the test – Fierce Network

    Google Fiber Puts Nokia’s Network Slicing Technology to the Ultimate Test

    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

    Kaseya Extends Community Investment with Addition of Technology Marketing Toolkit – Kaseya

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

    AI and the Trust Revolution: How Technology Is Transforming Human Connections – Foreign Affairs

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Alzheimer’s Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention

July 30, 2024
in Health
Alzheimer’s Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention
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PHILADELPHIA — Blood tests for Alzheimer’s disease biomarkers may not only be useful for clinical diagnosis but could also make it possible to test preventive therapies in people not yet showing any signs of the condition, researchers said.

In a prospectively followed cohort of older people with normal cognition and low amyloid-β (Aβ) plaque burdens in their brains, baseline plasma levels of tau and Aβ protein species predicted the speed at which Aβ plaques accumulated over 5 years of follow-up, according to Oskar Hansson, MD, PhD, of Skåne University Hospital in Malmö, Sweden, and colleagues.

Specifically, participants with a low ratio of two Aβ amino acid forms (Aβ42/40) and high ratio of tau217 phosphorylation (i.e., tau with a phosphate molecule attached at the threonine-217 residue, %p-tau217) showed dramatically faster plaque accumulation, the researchers reported in JAMA Neurology. The study was also to be presented at the Alzheimer’s Association International Conference (AAIC).

The report followed one from many of the same researchers, also presented at AAIC, indicating that a model based on this same pair of biomarkers outperformed human doctors in diagnosing Alzheimer’s disease in people with cognitive deficits.

For people without such symptoms, or even with Aβ substantial plaque burdens, the findings could pave the way for “primary prevention” trials to identify drugs or other therapies that keep Aβ from accumulating in the brain. These would be targeted at individuals who, because of family history, genetic features, or other factors, are thought likely to develop Alzheimer’s disease down the line.

Such trials, which necessarily must enroll people with no cognitive deficits and low plaque burdens, are currently not feasible. If participants were simply plucked randomly from the general population, either huge numbers or decades of follow-up would be needed to determine whether a particular therapy was effectively preventing plaque buildup and, hopefully, Alzheimer’s disease.

But if a subpopulation likely to undergo rapid Aβ accumulation could be identified, then such trials could be shorter and wouldn’t need so many participants to confirm an effect. That’s where the Aβ42/40 and %p-tau217 blood test comes in.

The study drew primarily from the so-called BioFINDER-2 cohort study underway in Sweden, which enrolled cognitively normal older people from 2017 to 2022 and followed them with tests including periodic PET scans to evaluate brain Aβ plaque burden. Overall, the cohort included 495 people, among whom 384 had low plaque burdens (
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Tags: Alzheimer’sbiomarkershealth
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July 11, 2025

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