* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, September 3, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

    TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

    Jenny Han Dropped a Major ‘The Summer I Turned Pretty’ Easter Egg Revealing [SPOILER] – yahoo.com

    Jenny Han Just Unveiled a Huge ‘The Summer I Turned Pretty’ Easter Egg That Changes Everything [SPOILER]

    Liam Payne’s Cousin Ross Harris Honors Late Singer With Emotional Song ‘Bones’ – yahoo.com

    Liam Payne’s Cousin Ross Harris Honors Late Singer with Emotional New Song ‘Bones

    Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

    Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

    Comanche Nation Entertainment closes casino near Devol – KSWO 7News

    Comanche Nation Entertainment Closes Casino Near Devol in Surprising Move

    Erykah Badu Announces ‘Abi & Alan’ Album With The Alchemist Will Be Delayed – yahoo.com

    Erykah Badu Opens Up About the Delay of Her Highly Anticipated ‘Abi & Alan’ Album with The Alchemist

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Blockchain lender Figure Technology seeks to raise up to $526M in IPO (FIGR:Pending) – Seeking Alpha

    Blockchain Lender Figure Technology Sets Sights on $526M in Thrilling IPO Launch

    New Technology from Ramsey Theory Group Brings Diagnostic Testing and Telehealth Directly into Patients’ Homes – Yahoo Finance

    Revolutionary Ramsey Theory Technology Delivers Diagnostic Testing and Telehealth Right to Your Doorstep

    China’s CATL sells stake in Finnish subcontract car manufacturer – Reuters

    China’s CATL Sells Stake in Finnish Auto Supplier in Strategic Move

    This Secret Technology Will Make The IPhone 17 Super Thin Air – VOI.ID

    How This Breakthrough Technology Will Make the iPhone 17 Incredibly Thin and Lightweight

    Gator football kicks off with excitement and new technology – WCJB | TV20

    Gator Football Kicks Off with Thrilling Action and Innovative Technology

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

    TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

    Jenny Han Dropped a Major ‘The Summer I Turned Pretty’ Easter Egg Revealing [SPOILER] – yahoo.com

    Jenny Han Just Unveiled a Huge ‘The Summer I Turned Pretty’ Easter Egg That Changes Everything [SPOILER]

    Liam Payne’s Cousin Ross Harris Honors Late Singer With Emotional Song ‘Bones’ – yahoo.com

    Liam Payne’s Cousin Ross Harris Honors Late Singer with Emotional New Song ‘Bones

    Country music star apologizes after drunken show ends with cops taking him down: ‘I’m not OK’ – PennLive.com

    Country Music Star Apologizes After Drunken Show Ends in Police Intervention: ‘I’m Not OK

    Comanche Nation Entertainment closes casino near Devol – KSWO 7News

    Comanche Nation Entertainment Closes Casino Near Devol in Surprising Move

    Erykah Badu Announces ‘Abi & Alan’ Album With The Alchemist Will Be Delayed – yahoo.com

    Erykah Badu Opens Up About the Delay of Her Highly Anticipated ‘Abi & Alan’ Album with The Alchemist

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Blockchain lender Figure Technology seeks to raise up to $526M in IPO (FIGR:Pending) – Seeking Alpha

    Blockchain Lender Figure Technology Sets Sights on $526M in Thrilling IPO Launch

    New Technology from Ramsey Theory Group Brings Diagnostic Testing and Telehealth Directly into Patients’ Homes – Yahoo Finance

    Revolutionary Ramsey Theory Technology Delivers Diagnostic Testing and Telehealth Right to Your Doorstep

    China’s CATL sells stake in Finnish subcontract car manufacturer – Reuters

    China’s CATL Sells Stake in Finnish Auto Supplier in Strategic Move

    This Secret Technology Will Make The IPhone 17 Super Thin Air – VOI.ID

    How This Breakthrough Technology Will Make the iPhone 17 Incredibly Thin and Lightweight

    Gator football kicks off with excitement and new technology – WCJB | TV20

    Gator Football Kicks Off with Thrilling Action and Innovative Technology

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Marvell Technology (MRVL) Loses 18.6% as Growth Outlook Fails to Impress – Yahoo Finance

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Health

Neutrophil PAD4: How does it function in cancer beyond promoting NETosis?

October 30, 2023
in Health
Neutrophil PAD4: How does it function in cancer beyond promoting NETosis?
Share on FacebookShare on Twitter

Neutrophil PAD4: How does it function in cancer beyond promoting NETosis?

Mechanisms involved in regulation of tumor progression by neutrophil PAD4. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28369

A new editorial paper titled “Neutrophil PAD4: how does it function in cancer beyond promoting NETosis?” has been published in Oncotarget.

Expansion of pathologically activated immune suppressive myeloid cells called myeloid-derived suppressor cells (MDSC) is one of the hallmarks of cancer. In most tumor types, MDSC are represented primarily by pathologically activated neutrophils (PMN-MDSC). In this new editorial, researchers Laura Garcia-Gerique and Yulia Nefedova from the Wistar Institute discuss their team’s recent study, published in Cancer Research, identifying a novel mechanism by which neutrophil PAD4 promotes cancer progression.

“Using several transplantable and genetically engineered mouse models, we demonstrated that tumor growth was accompanied by significantly elevated enzymatic activity of neutrophil PAD4. To further clarify the role of PAD4 in tumor progression, we utilized PAD4fl/fl MRP8Cre mice with targeted deletion of PAD4 in myeloid cells, primarily neutrophils,” the researchers explain.

PMN-MDSC originate in the bone marrow and migrate to various sites including tumor tissues and premetastatic niches. These cells have a relatively short lifespan (less than 48 hours), and therefore, are continually replaced from the bone marrow. Tumor-infiltrating PMN-MDSC possess a potent suppressive activity, as they are able to inhibit both antigen-specific immune responses of T cells and non-specific anti-CD3/CD28-stimulated responses. As a result, a highly immunosuppressive environment is created in tumors, which prevents their rejection via immunological mechanisms.

In addition, PMN-MDSC employ non-immunological mechanisms to facilitate tumor progression, including angiogenesis, remodeling of extracellular matrix, and production of cytokines. In patients with solid tumors, levels of MDSC in circulation and tumor tissues have been positively associated with a poor response to the therapy in many types of cancer and represent an independent indicator of poor outcomes. However, many of the details about how PMN-MDSC support cancer progression, and thus approaches for therapeutically targeting these cells remain enigmatic.

“Taken together, our study identified a new mechanism responsible for transcriptional regulation of neutrophil migration and a new mechanism by which neutrophil PAD4 is contributing to tumor progression. PAD4 inhibitors are in development and may enter early phase clinical trials in the future,” the researchers conclude.

More information:
Laura Garcia-Gerique et al, Neutrophil PAD4: how does it function in cancer beyond promoting NETosis?, Oncotarget (2023). DOI: 10.18632/oncotarget.28369

Hui Deng et al, A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression, Cancer Research (2022). DOI: 10.1158/0008-5472.CAN-21-4045

Provided by
Impact Journals LLC

Citation:
Neutrophil PAD4: How does it function in cancer beyond promoting NETosis? (2023, October 30)
retrieved 30 October 2023
from https://medicalxpress.com/news/2023-10-neutrophil-pad4-function-cancer-netosis.html

This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no
part may be reproduced without the written permission. The content is provided for information purposes only.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Medical Xpress – https://medicalxpress.com/news/2023-10-neutrophil-pad4-function-cancer-netosis.html

Tags: functionhealthNeutrophil
Previous Post

New research looks at life satisfaction in pandemic-era teens with mental health histories

Next Post

Light-activated muscle grafts show promise in aiding muscle recovery post-trauma

World Bank urges fresh push on economic threat of pollution – Reuters

World Bank Urges Immediate Action to Tackle the Economic Toll of Pollution

September 3, 2025
Canada’s Economy Slows, But Stops Short Of Recession – Finimize

Canada’s Economy Slows, But Stops Short Of Recession – Finimize

September 3, 2025
TS Entertainment bringing Malibu Jack’s to former Owensboro mall – Lane Report

TS Entertainment Launches Malibu Jack’s at Former Owensboro Mall Location

September 3, 2025
How Trump health conspiracy theories went wild on social media – CNN

The Wild Spread of Trump Health Conspiracy Theories on Social Media

September 3, 2025
Inside the Democratic plan to recapture the House majority in 2026 – The Washington Post

Democrats’ Bold Strategy to Win Back the House Majority in 2026

September 3, 2025
Grassland ecological compensation accounting based on the flow of emergy ecological products: a case from the Qinghai Tibet region, China – Nature

Innovative Grassland Ecological Compensation Accounting Using Emergy Flow: Insights from the Qinghai-Tibet Region

September 3, 2025
Climate scientists file a public, point-by-point rebuttal of Trump admin report casting doubt on climate change – CNN

Climate Scientists Deliver a Detailed Public Rebuttal to Trump Administration’s Climate Change Doubts

September 3, 2025
Earth’s Seasons Are Out of Sync, Scientists Discover From Space – ScienceAlert

Scientists Reveal Earth’s Seasons Are Falling Out of Sync Through Space Observations

September 3, 2025
Fasting glucose improvement following a short-term, culturally adapted lifestyle intervention in Latino adults at risk for type 2 diabetes mellitus: a quasi-experimental study – BMC Nutrition

Short-Term Culturally Tailored Lifestyle Intervention Boosts Fasting Glucose in Latino Adults at Risk for Type 2 Diabetes

September 3, 2025
Blockchain lender Figure Technology seeks to raise up to $526M in IPO (FIGR:Pending) – Seeking Alpha

Blockchain Lender Figure Technology Sets Sights on $526M in Thrilling IPO Launch

September 3, 2025

Categories

Archives

September 2025
MTWTFSS
1234567
891011121314
15161718192021
22232425262728
2930 
« Aug    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (804)
  • Economy (823)
  • Entertainment (21,703)
  • General (16,831)
  • Health (9,864)
  • Lifestyle (837)
  • News (22,149)
  • People (824)
  • Politics (831)
  • Science (16,033)
  • Sports (21,321)
  • Technology (15,803)
  • World (804)

Recent News

World Bank urges fresh push on economic threat of pollution – Reuters

World Bank Urges Immediate Action to Tackle the Economic Toll of Pollution

September 3, 2025
Canada’s Economy Slows, But Stops Short Of Recession – Finimize

Canada’s Economy Slows, But Stops Short Of Recession – Finimize

September 3, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version