TOPLINE:
Researchers have identified six blood biomarkers tied to changes in arterial inflammation in patients with rheumatoid arthritis (RA).
METHODOLOGY:
Researchers selected 24 candidate blood biomarkers previously associated with both RA and systemic inflammation.They measured biomarkers in 109 patients in the TARGET trial, which tested whether different treatments for RA reduced arterial inflammation.Along with biomarkers, they measured arterial inflammation via [18F] fluorodeoxyglucose (FDG)-PET/CT scans at baseline and 24 weeks.
TAKEAWAY:
Baseline levels of the biomarkers serum amyloid A, C-reactive protein, soluble tumor necrosis factor receptor 1, adiponectin, YKL-4, and osteoprotegerin were associated with significant changes in arterial inflammation on FDG-PET/CT scans.Adding these biomarkers to predictive models improved the adjusted R2 from 0.20 to 0.32 (likelihood ratio test, P=.0005).Researchers plan to validate these associations in a larger, external patient cohort.
IN PRACTICE:
This study is too preliminary to have practical applications.
SOURCE:
The study, led by Daniel Solomon, MD, of Brigham and Women’s Hospital, Boston, Massachusetts, was published on February 28 in the Journal of the American Heart Association.
DISCLOSURES:
The research was funded by a National Institutes of Health grant as well as the Foundation for the National Institutes of Health Biomarkers Consortium. Several authors reported salary support or consulting fees from pharmaceutical companies.
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