A retrotransposon for site-specific gene transfer

An engineered retrotransposon achieves targeted gene transfer into the human genome.

This is a preview of subscription content, access via your institution

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

209,00 € per year

only 17,42 € per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Log in

Learn about institutional subscriptions

Read our FAQs

Contact customer support

Fig. 1: Comparison of transposon systems used for transgene integration.

References

Zhang, X. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02137-y (2024).

Article 
PubMed 

Google Scholar 

Ivics, Z., Hackett, P. B., Plasterk, R. H. & Izsvák, Z. Cell91, 501–510 (1997).

Article 
CAS 
PubMed 

Google Scholar 

Wilson, M. H., Coates, C. J. & George, A. L. Jr. Mol. Ther.15, 139–145 (2007).

Bishop, D. C. et al. Blood138, 1504–1509 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Peters, J. E., Makarova, K. S., Shmakov, S. & Koonin, E. V. Proc. Natl. Acad. Sci. USA114, E7358–E7366 (2017).

CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Klompe, S. E., Vo, P. L. H., Halpin-Healy, T. S. & Sternberg, S. H. Nature571, 219–225 (2019).

Article 
CAS 
PubMed 

Google Scholar 

Strecker, J. et al. Science365, 48–53 (2019).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Lampe, G. D. et al. Nat. Biotechnol.42, 87–98 (2024).

Article 
CAS 
PubMed 

Google Scholar 

Luan, D. D., Korman, M. H., Jakubczak, J. L. & Eickbush, T. H. Cell72, 595–605 (1993).

Article 
CAS 
PubMed 

Google Scholar 

Wilkinson, M. E., Frangieh, C. J., Macrae, R. K. & Zhang, F. Science380, 301–308 (2023).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Download references

Author information

Authors and Affiliations

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

Fred Dyda & Alison B. Hickman

Corresponding author

Correspondence to
Fred Dyda.

Ethics declarations

Competing interests

The authors declare no competing interests.

About this article

Cite this article

Dyda, F., Hickman, A.B. A retrotransposon for site-specific gene transfer.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02180-9

Download citation

Published: 18 March 2024

DOI: https://doi.org/10.1038/s41587-024-02180-9

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Nature.com – https://www.nature.com/articles/s41587-024-02180-9