A retrotransposon for site-specific gene transfer

An engineered retrotransposon achieves targeted gene transfer into the human genome.

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Fig. 1: Comparison of transposon systems used for transgene integration.

References

Zhang, X. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02137-y (2024).

Article 
PubMed 

Google Scholar 

Ivics, Z., Hackett, P. B., Plasterk, R. H. & Izsvák, Z. Cell 91, 501–510 (1997).

Article 
CAS 
PubMed 

Google Scholar 

Wilson, M. H., Coates, C. J. & George, A. L. Jr. Mol. Ther. 15, 139–145 (2007).

Bishop, D. C. et al. Blood 138, 1504–1509 (2021).

Article 
CAS 
PubMed 

Google Scholar 

Peters, J. E., Makarova, K. S., Shmakov, S. & Koonin, E. V. Proc. Natl. Acad. Sci. USA 114, E7358–E7366 (2017).

CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Klompe, S. E., Vo, P. L. H., Halpin-Healy, T. S. & Sternberg, S. H. Nature 571, 219–225 (2019).

Article 
CAS 
PubMed 

Google Scholar 

Strecker, J. et al. Science 365, 48–53 (2019).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Lampe, G. D. et al. Nat. Biotechnol. 42, 87–98 (2024).

Article 
CAS 
PubMed 

Google Scholar 

Luan, D. D., Korman, M. H., Jakubczak, J. L. & Eickbush, T. H. Cell 72, 595–605 (1993).

Article 
CAS 
PubMed 

Google Scholar 

Wilkinson, M. E., Frangieh, C. J., Macrae, R. K. & Zhang, F. Science 380, 301–308 (2023).

Article 
CAS 
PubMed 
PubMed Central 
ADS 

Google Scholar 

Download references

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Authors and Affiliations

Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

Fred Dyda & Alison B. Hickman

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Correspondence to
Fred Dyda.

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The authors declare no competing interests.

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Dyda, F., Hickman, A.B. A retrotransposon for site-specific gene transfer.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02180-9

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Published: 18 March 2024

DOI: https://doi.org/10.1038/s41587-024-02180-9

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