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GEMS enables mRNA m6A methylation sensing in living cells and m6A-coupled protein delivery

January 3, 2024
in Science
GEMS enables mRNA m6A methylation sensing in living cells and m6A-coupled protein delivery
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Thousands of cellular mRNAs contain the methyl modification m6A, which plays critical roles in mRNA processing and gene expression. We developed GEMS, a genetically encoded m6A sensor that provides a simple readout for m6A methylation in living cells and offers a platform for achieving m6A-coupled effector protein expression.

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Fig. 1: Schematic of the GEMS system for sensing cellular m6A.

References

Flamand, M. F. et al. The proteins of mRNA modification: writers, readers, and erasers. Annu. Rev. Biochem. 92, 145–173 (2023). This review discusses the function and regulation of m6A and its links to physiology and disease.

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Owens, M. C. et al. Recent technical advances in the study of nucleic acid modifications. Mol. Cell 81, 4116–4136 (2021). This review describes methods for detecting m6A and other RNA modifications.

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Meyer, K. D. DART-seq: an antibody-free method for global m6A detection. Nat. Methods 16, 1275–1280 (2019). This paper describes the DART-seq method for transcriptome-wide m6A mapping.

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Jiang, X. et al. The role of m6A modification in the biological functions and diseases. Signal Transduct. Target. Ther. 6, 74 (2021). This review discusses roles of m6A in physiology and disease.

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Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Marayati, B. F., Thompson, M. G., Holley, C. L., Horner, S. M. & Meyer, K. D. Programmable protein expression using a genetically encoded m6A sensor. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01978-3 (2024).

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GEMS enables mRNA m6A methylation sensing in living cells and m6A-coupled protein delivery.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-01997-0

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Published: 02 January 2024

DOI: https://doi.org/10.1038/s41587-023-01997-0

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