Precise and versatile genome editing with click editors

Research Briefing

Published: 22 July 2024

Nature Biotechnology

(2024)Cite this article

We developed click editors, comprising HUH endonucleases, DNA-dependent DNA polymerases and CRISPR–Cas9 nickases, which together enable programmable precision genome engineering from simple DNA templates.

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Fig. 1: Click editing enzymes and mechanism.

References

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This is a summary of: Ferreira da Silva, J. et al. Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02324-x (2024).