* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Wednesday, March 25, 2026
Earth-News
  • Home
  • Business
  • Entertainment

    Lucas Ball Joins Forces with Twelve6 Entertainment in Thrilling New Partnership

    Fall River’s Day of Portugal announces dates, entertainment lineup for 2026 – Fall River Reporter

    Margaret Cho Opens Up About Comedy, Politics, and Life in Hollywood

    Bring Spring Freshness to Your Kitchen with Expert Chef Tips

    Community Unites to Shape the Future of Roanoke’s Berglund Center

    Uncover the Top 10 Most Played Songs from the ‘Love Story’ Soundtrack on Spotify

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology

    Datasea Launches First U.S. Commercial Acoustic Technology-Powered Wellness Care Robots, Paving the Way for Future Innovation

    Get in the Game: Spring Athletics Challenge at Rochester Institute of Technology

    How Prophetic Land Search Company is Revolutionizing Technology to Transform the Industry

    Is MACOM Technology Solutions (MTSI) the Next Big Opportunity After Its Recent Price Drop?

    Why Wall Street Insiders Are Racing to Buy This Fintech Stock

    Three Men Charged with Plotting to Smuggle US Artificial Intelligence Technology to China

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment

    Lucas Ball Joins Forces with Twelve6 Entertainment in Thrilling New Partnership

    Fall River’s Day of Portugal announces dates, entertainment lineup for 2026 – Fall River Reporter

    Margaret Cho Opens Up About Comedy, Politics, and Life in Hollywood

    Bring Spring Freshness to Your Kitchen with Expert Chef Tips

    Community Unites to Shape the Future of Roanoke’s Berglund Center

    Uncover the Top 10 Most Played Songs from the ‘Love Story’ Soundtrack on Spotify

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology

    Datasea Launches First U.S. Commercial Acoustic Technology-Powered Wellness Care Robots, Paving the Way for Future Innovation

    Get in the Game: Spring Athletics Challenge at Rochester Institute of Technology

    How Prophetic Land Search Company is Revolutionizing Technology to Transform the Industry

    Is MACOM Technology Solutions (MTSI) the Next Big Opportunity After Its Recent Price Drop?

    Why Wall Street Insiders Are Racing to Buy This Fintech Stock

    Three Men Charged with Plotting to Smuggle US Artificial Intelligence Technology to China

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

The chemistry of next-generation sequencing

October 17, 2023
in Science
The chemistry of next-generation sequencing
Share on FacebookShare on Twitter

References

Sanger, F., Nicklen, F. & Coulson, A. R. DNA sequencing with chain-terminating inhibitors. Proc. Natl Acad. Sci. USA 74, 5463–5467 (1977).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Tsien, R. Y., Ross, P., Fahnestock, M. & Johnston, A. DNA sequencing. Patent WO9106678A1 (1990).

Ronaghi, M., Uhlén, M. & Nyrén, P. A sequencing method based on real-time pyrophosphate. Science 281, 363–365 (1998).

Article 
CAS 
PubMed 

Google Scholar 

International Human Genome Consortium. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001).

Article 

Google Scholar 

Venter, J. C. et al. The sequence of the human genome. Science 291, 1304–1351 (2001).

Article 
CAS 
PubMed 

Google Scholar 

Barski, A. et al. High-resolution profiling of histone methylations in the human genome. Cell 129, 823–837 (2007).

Article 
CAS 
PubMed 

Google Scholar 

Johnson, G. D. S., Mortazavi, A., Myers, R. M. & Wold, B. Genome-wide mapping of in vivo protein–DNA interactions. Science 316, 1497–1502 (2007).

Article 
CAS 
PubMed 

Google Scholar 

Gupta, N. & Verma, V. K. Next-generation sequencing and its application: empowering in public health beyond reality. In Microbial Technology for the Welfare of Society: Microorganisms for Sustainability (ed. Arora, P.) Vol. 17 (Springer, 2019).

Willson, J. Sequencing — the next generation. Nature Milestones S7 (2021).

Burgess, D. The dawn of personal genomes. Nature Milestones S9 (2021).

Bentley, D. R. et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456, 53–59 (2008).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Wang, J. et al. The diploid genome sequence of an Asian individual. Nature 456, 60–66 (2008).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Furey, W. S. et al. Use of fluorescence resonance energy transfer to investigate the conformation of DNA substrates bound to the Klenow fragment. Biochemistry 37, 2979–2990 (1998).

Article 
CAS 
PubMed 

Google Scholar 

Canard, B. & Sarfati, R. S. DNA polymerase fluorescent substrates with reversible 3′-tags. Gene 148, 1–6 (1994).

Article 
CAS 
PubMed 

Google Scholar 

Welch, M. B. et al. Syntheses of nucleosides designed for combinatorial DNA sequencing. Chem. Eur. J. 5, 951–960 (1999).

Article 
CAS 

Google Scholar 

Metzker, M. L. et al. Termination of DNA synthesis by novel 3′-modified deoxyribonucleoside 5′-triphosphates. Nucleic Acids Res. 22, 4259–4267 (1994).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Turcatti, G., Romieu, A., Fedurco, M. & Tairi, A.-P. A new class of cleavable fluorescent nucleotides: synthesis and optimization as reversible terminators for DNA sequencing by synthesis. Nucleic Acids Res. 36, e25 (2008).

Article 
PubMed 
PubMed Central 

Google Scholar 

Staudinger, H. & Meyer, J. Über neue organische phosphorverbindungen III. Phosphinmethylenderivate und phosphinimine. Helv. Chim. Acta 2, 635 (1919).

Article 
CAS 

Google Scholar 

Balasubramanian, S. Sequencing nucleic acids: from chemistry to medicine. Chem. Commun. 47, 7281–7286 (2011).

Article 
CAS 

Google Scholar 

Barnes, C., Balasubramanian, S., Liu, X., Swerdlow, H. & Milton, J. Labelled nucleotides. US patent 7,057,026 B2 (2002).

Sarfati, S. R. et al. Synthesis of fluorescent or biotinylated nucleoside compounds. Tetrahedron 43, 3491–3497 (1987).

Article 
CAS 

Google Scholar 

Rosenblum, B. B. et al. New dye-labeled terminators for improved DNA sequencing patterns. Nucleic Acids Res. 25, 4500–4504 (1997).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Kiefer, J. R., Mao, C., Braman, J. C. & Beese, L. S. Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal. Nature 391, 304–307 (1998).

Article 
CAS 
PubMed 

Google Scholar 

Smith, G. P., Bailey, D. M. D., Sanches, R. M., Swerdlow, H. & Earnshaw, D. J. Modified polymerases for improved incorporation of nucleotide analogues. Patent WO 2005/024010 A1 (2003).

Ost, T. W. B., Smith, G. P., Balasubramanian, S., Rigatti, R. & Sanches, R. M. Improved polymerases. Patent WO 2006/120433 A1 (2006).

Smith, G. P., Bailey, D. M. D., Sanches-Kuiper, R. M., Swerdlow, H. & Earnshaw, D. J. Modified polymerases for improved incorporation of nucleotide analogues. US patent 8,852,910 B2 (2003).

Smith, M. et al. Modified molecular arrays. Patent WO 2005/065814 A1 (2005).

Kawashima, E., Farinelli, L. & Mayer, P. Method of nucleic acid amplification by extension of immobilized primers. Patent WO 9844151 (1998).

Mayer, P. Isothermal amplification of nucleic acids on a solid support. Patent WO 02/46456 (2001).

Robinson, R. A synthesis of tropinone. J. Chem. Soc. 111, 762–768 (1917).

Rodriguez, A. R. et al. Total synthesis of cyercene A and the biomimetic synthesis of (±)-9,10-deoxytridachione and (±)-ocellapyrone. Tetrahedron 63, 4500–4509 (2007).

Article 
CAS 

Google Scholar 

Wuts, P. G. M. & Greene, T. W. Greene’s Protective Groups in Organic Synthesis 4th edn (John Wiley & Sons, 2006).

Baran, P. S., Maimone, T. J. & Richter, J. M. Total synthesis of marine natural products without using protecting groups. Nature 446, 404–408 (2007).

Article 
CAS 
PubMed 

Google Scholar 

Trost, B. M. The atom economy—a search for synthetic efficiency. Science 254, 1471–1477 (1991).

Article 
CAS 
PubMed 

Google Scholar 

Koboldt, D. C., Meltz Steinberg, K., Larson, D. E., Wilson, R. K. & Mardis, E. R. The next-generation sequencing revolution and its impact on genomics. Cell 155, 27–38 (2013).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Rodriguez, R. et al. Small molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat. Chem. Biol. 8, 301–310 (2012).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Rodriguez, R. & Miller, K. M. Unravelling the genomic targets of small molecules using high-throughput sequencing. Nat. Rev. Genet. 15, 783–796 (2014).

Article 
CAS 
PubMed 

Google Scholar 

Mortazavi, A., Williams, B. A., McCue, K., Schaeffer, L. & Wold, B. Mapping and quantifying mammalian transcriptomes by RNA-seq. Nat. Methods 5, 621–628 (2008).

Article 
CAS 
PubMed 

Google Scholar 

Ståhl, P. L. et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science 353, 78–82 (2016).

Article 
PubMed 

Google Scholar 

Shendure, J. et al. DNA sequencing at 40: past, present and future. Nature 550, 346–353 (2017).

Article 

Google Scholar 

Newby, G. A. et al. Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature 595, 295–302 (2021).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Zhu, N. et al. A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727–733 (2020).

Article 
CAS 
PubMed 
PubMed Central 

Google Scholar 

Veetil, A. T. & Krishnan, Y. In Advanced Chemical Biology (eds Hang, H. C., Pratt, M. R. & Prescher, J. A.) Ch. 2, pp 9–30 (Wiley-VCH, 2023).

Download references

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Nature.com – https://www.nature.com/articles/s41587-023-01986-3

Tags: chemistrynext-generationscience
Previous Post

Sir Ian Wilmut 1944–2023

Next Post

Tiger Woods announces stacked Hero World Challenge field minus Rory McIlroy, Jon Rahm

Ecological boundaries must be incorporated in the post-COP30 climate regime – Nature

March 24, 2026

Highly and casually active citizen scientists contribute equally valuable data – EurekAlert!

March 24, 2026

What’s for Lunch? Celebrating 25 Years of Inspiring Science in Schools

March 24, 2026

Today on ARC PDX | March 24, 2026 | PCC and striking unions look to reach an agreement – KATU

March 24, 2026

Disney’s Latest ‘Create Your World’ Episode Goes Behind the Viktor & Rolf Cinderella Doll – WWD

March 24, 2026

The Economy Isn’t Collapsing-But Bigger Risks Are on the Horizon

March 24, 2026

Lucas Ball Joins Forces with Twelve6 Entertainment in Thrilling New Partnership

March 24, 2026

Cityblock Health Unveils Groundbreaking Report on AI Transforming Care for Medicaid and Dual-Eligible Populations

March 24, 2026

Meet the Washington Lawmakers Retiring or Pursuing New Offices in 2024

March 24, 2026

Datasea Launches First U.S. Commercial Acoustic Technology-Powered Wellness Care Robots, Paving the Way for Future Innovation

March 24, 2026

Categories

Archives

March 2026
M T W T F S S
 1
2345678
9101112131415
16171819202122
23242526272829
3031  
« Feb    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (1,135)
  • Economy (1,153)
  • Entertainment (22,029)
  • General (20,593)
  • Health (10,191)
  • Lifestyle (1,167)
  • News (22,149)
  • People (1,155)
  • Politics (1,171)
  • Science (16,368)
  • Sports (21,654)
  • Technology (16,135)
  • World (1,146)

Recent News

Ecological boundaries must be incorporated in the post-COP30 climate regime – Nature

March 24, 2026

Highly and casually active citizen scientists contribute equally valuable data – EurekAlert!

March 24, 2026
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version