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The rise of patient avatars in precision oncology

July 26, 2024
in Science
The rise of patient avatars in precision oncology
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Published: 26 July 2024

Nature Biotechnology

(2024)Cite this article

Response to anticancer treatment is dictated not only by availability of molecular targets within the tumor, but also by the highly heterogenous, patient-specific composition of cells within tumors and their complex tumor microenvironment (TME). Consequently, some patients demonstrate remarkable responses to anticancer therapies, whereas others experience negligible effects. Thus, there is an urgent need for more effective strategies to preselect patients for therapies, mitigating the risk of administering ineffective and potentially harmful drugs and speeding up the process for patients to receive the most effective treatment.

The most promising solution to tackle heterogenous responses to treatment is the creation of patient-derived models (‘patient avatars’) that accurately represent an individual’s tumor. Tailoring therapies for cancer patients based on their avatars’ responses to anticancer drugs could change the entire approach to treating patients with solid tumor diseases. Although introducing these human in vitro systems into clinical settings has been challenging, recent evidence has demonstrated the readiness of these models for clinical translation.

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References

Vlachogiannis, G. et al. Science 359, 920–926 (2018).

Tan, T. et al. Cell Rep. Med. 4, 101335 (2023).

Dekkers, J. F. et al. Nat. Biotechnol. 41, 60–69 (2023).

Dijkstra, K. K. et al. Cell 174, 1586–1598.e12 (2018).

Harter, M. F. et al. Nat. Biomed. Eng. 8, 345–360 (2023).

Neal, J. T. et al. Cell 175, 1972–1988.e16 (2018).

Gavert, N. et al. Nat. Cancer 3, 219–231 (2022).

Kaptein, P. et al. Sci. Transl. Med. 14, eabj9779 (2022).

Voabil, P. et al. Nat. Med. 27, 1250–1261 (2021).

Lorenzo-Martín, L. F. et al. Nature 629, 450–457 (2024).

Kong, J. et al. Nat. Commun. 11, 5485 (2020).

Neufeld, L. et al. Sci. Adv. 7, eabi9119 (2021).

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Author information

Authors and Affiliations

Berlin Institute of Health (BIH) at Charité — Universitätsmedizin Berlin, BIH Center for Regenerative Therapies (BCRT), Experimental Immunotherapy, Berlin, Germany

Lukas Ehlen & Michael Schmueck-Henneresse

Department of Anesthesiology and Intensive Care Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany

Lukas Ehlen

Contributions

L.E. and M.S.-H. wrote the manuscript. Both authors have read and approved the manuscript in its final form.

Corresponding authors

Correspondence to
Lukas Ehlen or Michael Schmueck-Henneresse.

Ethics declarations

Competing interests

The authors declare no competing interests.

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Cite this article

Ehlen, L., Schmueck-Henneresse, M. The rise of patient avatars in precision oncology.
Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02335-8

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Published: 26 July 2024

DOI: https://doi.org/10.1038/s41587-024-02335-8

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