* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Monday, August 25, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    ‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

    When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

    Quotes of the Week: Peacemaker, Project Runway, Countdown and More – yahoo.com

    This Week’s Most Memorable Quotes from Peacemaker, Project Runway, Countdown, and More!

    Drake Appears in Teaser for Bobbi Althoff’s New Podcast ‘Not This Again’ – yahoo.com

    Drake Drops a Surprise Cameo in Bobbi Althoff’s Thrilling New Podcast Teaser ‘Not This Again

    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    How to watch ‘F1: The Movie’ on Prime Video – About Amazon

    Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

    Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

    UNLV Responds to Workforce Need with Microcredential in Nuclear Technology – University of Nevada, Las Vegas | UNLV

    UNLV Unveils Cutting-Edge Microcredential Program to Fuel Growth in Nuclear Technology

    Why Technology Will Never Take Over Completely – Patheos

    Why Technology Will Never Completely Control Our Lives

    Alcorn State awarded grant to boost STEM with VR technology – WJTV

    Alcorn State Secures Grant to Transform STEM Education Through Cutting-Edge VR Technology

    Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

    Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

    Teaching older adults how to use technology – WWNY

    Empowering Older Adults to Master Technology with Confidence

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    ‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

    When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

    Quotes of the Week: Peacemaker, Project Runway, Countdown and More – yahoo.com

    This Week’s Most Memorable Quotes from Peacemaker, Project Runway, Countdown, and More!

    Drake Appears in Teaser for Bobbi Althoff’s New Podcast ‘Not This Again’ – yahoo.com

    Drake Drops a Surprise Cameo in Bobbi Althoff’s Thrilling New Podcast Teaser ‘Not This Again

    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    From polka to Poison, Corn Palace adjusts entertainment offerings with the times – Mitchell Republic

    How to watch ‘F1: The Movie’ on Prime Video – About Amazon

    Experience the Thrill: How to Stream ‘F1: The Movie’ on Prime Video

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

    FOX One is now available on Prime Video: Here’s everything to know – About Amazon

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

    Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

    UNLV Responds to Workforce Need with Microcredential in Nuclear Technology – University of Nevada, Las Vegas | UNLV

    UNLV Unveils Cutting-Edge Microcredential Program to Fuel Growth in Nuclear Technology

    Why Technology Will Never Take Over Completely – Patheos

    Why Technology Will Never Completely Control Our Lives

    Alcorn State awarded grant to boost STEM with VR technology – WJTV

    Alcorn State Secures Grant to Transform STEM Education Through Cutting-Edge VR Technology

    Hyundai: The Only Way To Beat China Is To Embrace Technology – InsideEVs

    Hyundai’s Bold Strategy to Outpace China with Cutting-Edge Technology

    Teaching older adults how to use technology – WWNY

    Empowering Older Adults to Master Technology with Confidence

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Technology

Bayesians Moving from Defense to Offense

December 23, 2023
in Technology
Bayesians Moving from Defense to Offense
Share on FacebookShare on Twitter

Erik van Zwet, Sander Greenland, Guido Imbens, Simon Schwab, Steve Goodman, and I write:

We have examined the primary efficacy results of 23,551 randomized clinical trials from the Cochrane Database of Systematic Reviews.

We estimate that the great majority of trials have much lower statistical power for actual effects than the 80 or 90% for the stated effect sizes. Consequently, “statistically significant” estimates tend to seriously overestimate actual treatment effects, “nonsignificant” results often correspond to important effects, and efforts to replicate often fail to achieve “significance” and may even appear to contradict initial results. To address these issues, we reinterpret the P value in terms of a reference population of studies that are, or could have been, in the Cochrane Database.

This leads to an empirical guide for the interpretation of an observed P value from a “typical” clinical trial in terms of the degree of overestimation of the reported effect, the probability of the effect’s sign being wrong, and the predictive power of the trial.

Such an interpretation provides additional insight about the effect under study and can guard medical researchers against naive interpretations of the P value and overoptimistic effect sizes. Because many research fields suffer from low power, our results are also relevant outside the medical domain.

Also this new paper from Zwet with Lu Tian and Rob Tibshirani:

Evaluating a shrinkage estimator for the treatment effect in clinical trials

The main objective of most clinical trials is to estimate the effect of some treatment compared to a control condition. We define the signal-to-noise ratio (SNR) as the ratio of the true treatment effect to the SE of its estimate. In a previous publication in this journal, we estimated the distribution of the SNR among the clinical trials in the Cochrane Database of Systematic Reviews (CDSR). We found that the SNR is often low, which implies that the power against the true effect is also low in many trials. Here we use the fact that the CDSR is a collection of meta-analyses to quantitatively assess the consequences. Among trials that have reached statistical significance we find considerable overoptimism of the usual unbiased estimator and under-coverage of the associated confidence interval. Previously, we have proposed a novel shrinkage estimator to address this “winner’s curse.” We compare the performance of our shrinkage estimator to the usual unbiased estimator in terms of the root mean squared error, the coverage and the bias of the magnitude. We find superior performance of the shrinkage estimator both conditionally and unconditionally on statistical significance.

Let me just repeat that last sentence:

We find superior performance of the shrinkage estimator both conditionally and unconditionally on statistical significance.

From a Bayesian standpoint, this is no surprise. Bayes is optimal if you average over the prior distribution and can be reasonable if averaging over something close to the prior. Especially reasonable in comparison to naive unregularized estimates (as here).

Erik summarizes:

We’ve determined how much we gain (on average over the Cochrane Database) by using our shrinkage estimator. It turns out to be about a factor 2 more efficient (in terms of the MSE) than the unbiased estimator. That’s roughly like doubling the sample size! We’re using similar methods as our forthcoming paper about meta-analysis with a single trial.

People sometimes ask me how I’ve changed as a statistician over the years. One answer I’ve given is that I’ve gradually become more Bayesian. I started out as a skeptic, concerned about Bayesian methods at all; then in grad school I started using Bayesian statistics in applications and realizing it could solve some problems for me; when writing BDA and ARM, still having the Bayesian cringe and using flat priors as much as possible, or not talking about priors at all; then with Aleks, Sophia, and others moving toward weakly informative priors; eventually under the influence of Erik and others trying to use direct prior information. At this point I’ve pretty much gone full Lindley.

Just as a comparison to where my colleagues and I are now, check out my response in 2008 to a question from Sanjay Kaul about how to specify a prior distribution for a clinical trial. I wrote:

I suppose the best prior distribution would be based on a multilevel model (whether implicit or explicit) based on other, similar experiments. A noninformative prior could be ok but I prefer something weakly informative to avoid your inferences being unduly affected by extremely unrealistic possibilities in the tail of the distribuiton.

Nothing wrong with this advice, exactly, but I was still leaning in the direction of noninformativeness in a way that I would not anymore. Sander Greenland replied at the time with a recommendation to use direct prior information. (And, just for fun, here’s a discussion from 2014 on a topic where Sander and I disagree.)

Erik concludes:

I really think it’s kind of irresponsible now not to use the information from all those thousands of medical trials that came before. Is that very radical?

That last question reminds me of our paper from 2008, Bayes: Radical, Liberal, or Conservative?

P.S. Also this:

You can click through to see the whole story.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : Hacker News – https://statmodeling.stat.columbia.edu/2023/12/23/bayesians-moving-from-defense-to-offense-i-really-think-its-kind-of-irresponsible-now-not-to-use-the-information-from-all-those-thousands-of-medical-trials-that-came-before-is-that-very/

Tags: BayesiansMovingtechnology
Previous Post

The unfortunate math behind consulting companies (2011)

Next Post

AI companies required to disclose copyrighted training data under new bill

Dengue – World Health Organization (WHO)

Dengue – World Health Organization (WHO)

August 25, 2025
5 Years On, China’s Property Crisis Has No End in Sight – The New York Times

Five Years Later, China’s Property Crisis Shows No Signs of Easing

August 25, 2025
‘When Calls the Heart’ Fans All Want the Same Thing After Seeing the Show’s Latest Update – yahoo.com

When Calls the Heart’ Fans Rally Together in Excitement Over Exciting New Update!

August 25, 2025
State regulators approve sharp health insurance rate increases – Insurance Business America

State Regulators Greenlight Steep Health Insurance Rate Hikes

August 25, 2025
Pols & Politics: Audit finds Mass. government fraudulent spending nearly doubled in Q4 – Boston Herald

Pols & Politics: Audit finds Mass. government fraudulent spending nearly doubled in Q4 – Boston Herald

August 25, 2025
Eightmile Dam rebuild & restoration – Washington State Department of Ecology (.gov)

Breathing New Life into Eightmile Dam: An Ambitious Rebuild and Restoration Effort

August 24, 2025
Scientists Sequenced the DNA of the ‘Last Neanderthal’—and It Alters Human History – yahoo.com

Scientists Unlock the DNA of the ‘Last Neanderthal,’ Revolutionizing Our View of Human History

August 24, 2025
RIKEN, Japan’s Leading Science Institute, Taps Fujitsu and NVIDIA for Next Flagship Supercomputer – NVIDIA Blog

Japan’s Leading Science Institute Teams Up with Fujitsu and NVIDIA to Create Next-Generation Supercomputer

August 24, 2025
Is a relief rally coming for Equity LifeStyle Properties Inc. holders – July 2025 Retail & Weekly High Return Opportunities – Newser

Is a relief rally coming for Equity LifeStyle Properties Inc. holders – July 2025 Retail & Weekly High Return Opportunities – Newser

August 24, 2025
Figure Technology Solutions, Inc. Files Registration Statement for Proposed Initial Public Offering – Business Wire

Figure Technology Solutions, Inc. Unveils Exciting Plans for Its Upcoming Initial Public Offering

August 24, 2025

Categories

Archives

August 2025
MTWTFSS
 123
45678910
11121314151617
18192021222324
25262728293031
« Jul    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (788)
  • Economy (809)
  • Entertainment (21,688)
  • General (16,657)
  • Health (9,849)
  • Lifestyle (821)
  • News (22,149)
  • People (810)
  • Politics (818)
  • Science (16,020)
  • Sports (21,307)
  • Technology (15,789)
  • World (790)

Recent News

Dengue – World Health Organization (WHO)

Dengue – World Health Organization (WHO)

August 25, 2025
5 Years On, China’s Property Crisis Has No End in Sight – The New York Times

Five Years Later, China’s Property Crisis Shows No Signs of Easing

August 25, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version