* . *
  • About
  • Advertise
  • Privacy & Policy
  • Contact
Saturday, June 14, 2025
Earth-News
  • Home
  • Business
  • Entertainment
    The Media and Entertainment Deal Machine Is Revving Up – WSJ

    The Media and Entertainment Deal Machine Is Gearing Up for Action

    Op-Ed: Data Storage and Protection in Today’s Media & Entertainment Industry – Sports Video Group

    How Data Storage and Protection Are Transforming the Media & Entertainment Industry

    The Analyst Verdict: PENN Entertainment In The Eyes Of 7 Experts – Nasdaq

    7 Experts Reveal the Ultimate Verdict on PENN Entertainment

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    Leading Proxy Advisory Firm Glass Lewis Recommends Shareholders Vote “FOR” Both of PENN Entertainment’s Director Nominees on the WHITE Proxy Card – Business Wire

    Glass Lewis Urges Shareholders to Support All PENN Entertainment Director Nominees on the WHITE Proxy Card

    Cisco Partners with Monumental Sports & Entertainment to Power New D.C. Arena – Cisco Newsroom

    Cisco Teams Up with Monumental Sports & Entertainment to Revolutionize the New D.C. Arena Experience

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    New Semiconductor Technology Could Supercharge 6G Delivery – SciTechDaily

    Revolutionary Semiconductor Technology Set to Turbocharge 6G Connectivity

    UTC To Host Quantum Technology Workshop June 23-25 – Chattanoogan.com: Breaking News

    Join the Quantum Technology Workshop This June 23-25!

    Rimac Technology Powers the Bugatti Tourbillon with Cutting-Edge Battery and Powertrain Tech – Rimac Newsroom

    Rimac Technology Drives the Bugatti Tourbillon with Revolutionary Battery and Powertrain Innovation

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

    Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
  • Home
  • Business
  • Entertainment
    The Media and Entertainment Deal Machine Is Revving Up – WSJ

    The Media and Entertainment Deal Machine Is Gearing Up for Action

    Op-Ed: Data Storage and Protection in Today’s Media & Entertainment Industry – Sports Video Group

    How Data Storage and Protection Are Transforming the Media & Entertainment Industry

    The Analyst Verdict: PENN Entertainment In The Eyes Of 7 Experts – Nasdaq

    7 Experts Reveal the Ultimate Verdict on PENN Entertainment

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    3 Arts Entertainment Expands Into News With Acquisition of OManagement (Exclusive) – The Hollywood Reporter

    Leading Proxy Advisory Firm Glass Lewis Recommends Shareholders Vote “FOR” Both of PENN Entertainment’s Director Nominees on the WHITE Proxy Card – Business Wire

    Glass Lewis Urges Shareholders to Support All PENN Entertainment Director Nominees on the WHITE Proxy Card

    Cisco Partners with Monumental Sports & Entertainment to Power New D.C. Arena – Cisco Newsroom

    Cisco Teams Up with Monumental Sports & Entertainment to Revolutionize the New D.C. Arena Experience

  • General
  • Health
  • News

    Cracking the Code: Why China’s Economic Challenges Aren’t Shaking Markets, Unlike America’s” – Bloomberg

    Trump’s Narrow Window to Spread the Truth About Harris

    Trump’s Narrow Window to Spread the Truth About Harris

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    Israel-Gaza war live updates: Hamas leader Ismail Haniyeh assassinated in Iran, group says

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    PAP Boss to Niger Delta Youths, Stay Away from the Protest

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Court Restricts Protests In Lagos To Freedom, Peace Park

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Fans React to Jazz Jennings’ Inspiring Weight Loss Journey

    Trending Tags

    • Trump Inauguration
    • United Stated
    • White House
    • Market Stories
    • Election Results
  • Science
  • Sports
  • Technology
    New Semiconductor Technology Could Supercharge 6G Delivery – SciTechDaily

    Revolutionary Semiconductor Technology Set to Turbocharge 6G Connectivity

    UTC To Host Quantum Technology Workshop June 23-25 – Chattanoogan.com: Breaking News

    Join the Quantum Technology Workshop This June 23-25!

    Rimac Technology Powers the Bugatti Tourbillon with Cutting-Edge Battery and Powertrain Tech – Rimac Newsroom

    Rimac Technology Drives the Bugatti Tourbillon with Revolutionary Battery and Powertrain Innovation

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    “Co-creation” boosts commercial technology for dual-use defense applications – Breaking Defense

    MSI Viking and Mahr Host Technology Day – WSPA 7NEWS

    Step Inside the Thrilling World of MSI Viking and Mahr Technology Day!

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    6.12pm is the new 8pm – Go Technology – cgastrategy.com

    Trending Tags

    • Nintendo Switch
    • CES 2017
    • Playstation 4 Pro
    • Mark Zuckerberg
No Result
View All Result
Earth-News
No Result
View All Result
Home Science

Shattering Old Beliefs: Antipsychotic Drugs Work Differently Than Scientists Thought

August 5, 2023
in Science
Shattering Old Beliefs: Antipsychotic Drugs Work Differently Than Scientists Thought
Share on FacebookShare on Twitter

Mental Health Medication Art Illustration

Northwestern Medicine scientists have made a groundbreaking discovery that redefines our understanding of how antipsychotic drugs work, revealing that their interaction with D1 dopamine receptor-expressing neurons, not D2, better predicts their efficacy in treating schizophrenia.

New research finding about how drugs modulate the brain in schizophrenia could lead to better treatments.

Antipsychotic drugs used to treat the millions of people in the U.S. diagnosed with schizophrenia often have numerous undesirable side effects. Additionally, these drugs are ineffective for many individuals, leading to an urgent requirement for the development of more efficacious drugs.

New Approach for Drug Development

Northwestern Medicine scientists have uncovered a promising pathway for creating more effective treatments for the crippling symptoms of schizophrenia. Traditionally, researchers have screened antipsychotic drug candidates by observing their effects on mouse behavior. However, the innovative approach adopted by a Northwestern lab has proven to be superior in predicting the drugs’ effectiveness in patients.

The study discovered that antipsychotic drugs – which inhibit the overactive dopamine causing the symptoms of schizophrenia – interact with a completely different neuron than scientists originally believed.

“This is a landmark finding that completely revises our understanding of the neural basis for psychosis and charts a new path for developing new treatments for it,” said lead investigator Jones Parker, assistant professor of neuroscience at Northwestern University Feinberg School of Medicine.” It opens new options to develop drugs that have fewer adverse side effects than the current ones.”

The study was published on July 13 in the journal Nature Neuroscience.

Understanding Dopamine’s Role

Schizophrenia patients have elevated dopamine levels in a brain region called the striatum, which hosts two primary types of specialized brain cells or neurons. These cells are distinguished by the type of dopamine receptor they possess: D1 and D2.

Receptors on neurons are like locks waiting for the key that turns them on. Picture two populations of neurons, one that expresses locks called D1 receptors and the other called D2 receptors. Dopamine is a key for both receptors, but antipsychotics only block the D2 receptor locks. Therefore, experts have assumed these drugs preferentially act on neurons that express the D2 receptor locks. But, in fact, it was the other brain cells – the neighboring ones in the striatum with D1 receptors – that responded to antipsychotic drugs in a manner that predicted clinical effect.

Shifting the Paradigm

“The dogma has been that antipsychotic drugs preferentially affect striatal neurons that express D2 dopamine receptors,” Parker said. “However, when our team tested this idea, we found that how a drug affects the activity of D2 receptor-expressing striatal neurons has little bearing on whether it is antipsychotic in humans. Instead, a drug’s effect on the other striatal neuron type, the one that expresses D1 dopamine receptors, is more predictive of whether they actually work.”

Limitations of Current Treatments

Schizophrenia is a debilitating brain disorder affecting roughly 1 in 100 people or more than 2.5 million people in the U.S. While existing antipsychotics are effective for the hallmark symptoms of schizophrenia such as hallucinations and delusions, they are ineffective for the other symptoms of schizophrenia such as deficits in cognitive and social function.

Furthermore, current antipsychotics are completely ineffective in more than 30% of patients with treatment-resistant schizophrenia (more than 750,000 people in the U.S.). The use of these drugs also is limited by their adverse effects, including tardive dyskinesia (uncontrollable body movements) and parkinsonism (rigidity, tremors, and slowness of movement).

Novel Insights and Future Directions

The new study for the first time determined how antipsychotic drugs modulate the region of the brain thought to cause psychosis in living animals.

“Our study exposed our lack of understanding for how these drugs work and uncovered new therapeutic strategies for developing more effective antipsychotics,” Parker said.

Reference: “Antipsychotic drug efficacy correlates with the modulation of D1 rather than D2 receptor-expressing striatal projection neurons” by Seongsik Yun, Ben Yang, Justin D. Anair, Madison M. Martin, Stefan W. Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, Ann Kennedy and Jones G. Parker, 13 July 2023, Nature Neuroscience.
DOI: 10.1038/s41593-023-01390-9

Other Northwestern authors include first author Seongsik Yun, Ben Yang, Justin Anair, Madison Martin, Stefan Fleps, Arin Pamukcu, Nai-Hsing Yeh, Anis Contractor, and Ann Kennedy.

The research was supported by the National Institute of Neurological Disorders and Stroke grant R01NS122840 and the National Institute of Mental Health grant K01MH11313201, both of the National Institutes of Health and the Whitehall Foundation.

>>> Read full article>>>
Copyright for syndicated content belongs to the linked Source : SciTechDaily – https://scitechdaily.com/shattering-old-beliefs-antipsychotic-drugs-work-differently-than-scientists-thought/

Tags: BeliefsscienceShattering
Previous Post

Scientists Discover Way To Defeat Crop-Killing Gray Mold Without Toxic Chemicals

Next Post

Revolutionizing Optical Imaging With Complex-Domain Neural Networks

New Semiconductor Technology Could Supercharge 6G Delivery – SciTechDaily

Revolutionary Semiconductor Technology Set to Turbocharge 6G Connectivity

June 14, 2025
Saturday Sports: It’s the finals for the NBA, Stanley Cup and FIFA World Club Cup – NPR

Saturday Showdown: NBA, Stanley Cup, and FIFA World Club Cup Finals Heat Up!

June 14, 2025
Trump’s Proposed Budget Would Cut a Major Ecology Program – The New York Times

Trump’s Proposed Budget Threatens Major Ecology Program with Significant Cuts

June 14, 2025
The science of sweating: Staying cool in Southern Colorado – FOX21 News Colorado

The science of sweating: Staying cool in Southern Colorado – FOX21 News Colorado

June 14, 2025
Scientists discover strong, unexpected link between Earth’s magnetic field and oxygen levels – Live Science

Scientists Uncover Surprising Connection Between Earth’s Magnetic Field and Oxygen Levels

June 14, 2025
Doctors say this lifestyle choice is the biggest contributor to cognitive decline and dementia – Earth.com

Doctors Uncover the Lifestyle Habit Most Connected to Cognitive Decline and Dementia

June 14, 2025
The economic risks of Israel’s Iran attack – Axios

The High-Stakes Economic Fallout of an Israeli Strike on Iran

June 14, 2025
The Media and Entertainment Deal Machine Is Revving Up – WSJ

The Media and Entertainment Deal Machine Is Gearing Up for Action

June 14, 2025
Kenvue mulls sale of some skin health and beauty brands, sources say – Reuters

Kenvue Explores Selling Select Skin Health and Beauty Brands to Refocus Growth

June 14, 2025
Trump’s aggressive moves on immigration protests put Democrats in a political bind – CNN

Trump’s Bold Immigration Crackdown Puts Democrats in a Tough Spot

June 14, 2025

Categories

Archives

June 2025
MTWTFSS
 1
2345678
9101112131415
16171819202122
23242526272829
30 
« May    
Earth-News.info

The Earth News is an independent English-language daily published Website from all around the World News

Browse by Category

  • Business (20,132)
  • Ecology (685)
  • Economy (700)
  • Entertainment (21,602)
  • General (15,375)
  • Health (9,741)
  • Lifestyle (704)
  • News (22,149)
  • People (701)
  • Politics (706)
  • Science (15,917)
  • Sports (21,201)
  • Technology (15,687)
  • World (682)

Recent News

New Semiconductor Technology Could Supercharge 6G Delivery – SciTechDaily

Revolutionary Semiconductor Technology Set to Turbocharge 6G Connectivity

June 14, 2025
Saturday Sports: It’s the finals for the NBA, Stanley Cup and FIFA World Club Cup – NPR

Saturday Showdown: NBA, Stanley Cup, and FIFA World Club Cup Finals Heat Up!

June 14, 2025
  • About
  • Advertise
  • Privacy & Policy
  • Contact

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

No Result
View All Result

© 2023 earth-news.info

Go to mobile version